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Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

How does the non-structural protein 1 affect COVID-19 pathogenicity?

Researchers discuss the effects of the SARS-CoV-2 non-structural protein 1 (Nsp1), which binds to the ribosomal subunit thus inhibiting translation.

20 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Novel mathematical model could predict the evolutionary trend of SARS-CoV-2

Researchers used a novel mathematical model to simulate SARS-CoV-2 dynamics inside the host.

17 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Researchers find unusual way of stabilizing cancer-suppressing protein

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent.

14 Mar 2022

CR Forum to honor Cleveland Clinic researcher with a 2022 Top Ten Clinical Research Achievement Award

Paul Marasco, PhD, Associate Staff, Department of Biomedical Engineering at Cleveland Clinic, will be honored with a 2022 Top Ten Clinical Research Achievement Award by the Clinical Research Forum (CR Forum).

12 Mar 2022

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

Researchers evaluated the efficacy of viral spike domain 2-specific human monoclonal antibodies delivered intranasally, against all beta coronaviruses in hamsters and mice.

11 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

Slowing down the DNA replication speed increases cell reprogramming efficiency

Adult cells in our body can only give rise to the same cell type. For example, a skin cell cannot give rise to a muscle cell but to skin cells only.

7 Mar 2022

New treatment strategy makes pancreatic tumors sensitive to immunotherapy, mice study shows

Pancreatic cancer is one of the most aggressive and deadly tumor types and notorious for its resistance to virtually all types of treatment, including newer immunotherapies.

7 Mar 2022

Diabetes and the mTOR pathway in COVID-19 patients

A new study discusses the possible etiopathogenetic mechanisms associated with diabetes that could enhance the severity of COVID-19.

6 Mar 2022

Study shows targeting DDX3 with RK-33 reduced the viral load in four isolates of SARS-CoV-2

A new study has focused on developing a novel anti-SARS-CoV-2 therapy using HTA directed against the human host DEAD-box RNA helicase.

3 Mar 2022

Assessing the potential of IFNa subtypes in suppressing SARS-CoV-2

A recent study analyzes IFNa subtypes for their therapeutic potential against SARS-CoV-2 and identified the underlying immune signatures and mechanisms.

3 Mar 2022

Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Researchers evaluated the synergistic activity of drugs acting against non-structural protein 1 of SARS-CoV-2 to decrease the viral infectivity.

2 Mar 2022

Intestinal cells can change specializations during their lives, finds study

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes.

1 Mar 2022

A ubiquitous protein may be key to the survival of neurons most impacted by glaucoma

A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report.

1 Mar 2022

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Researchers investigated protein interactions of SARS-CoV-2 with host and viral RNAs in infected cells.

1 Mar 2022

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers assessed the immunogenicity of the self-developed recombinant adenovirus vector (rAd5) vaccine on macaques. They evaluated the efficacy of three candidate vaccines, ED88, ED90, and ED94, to select the most appropriate one for future development.

1 Mar 2022

Pioneering technique uses a magnetic device to stimulate touch sensitive brain glial cells

Scientists at UCL have developed a new technique that uses microscopic magnetic particles to remotely activate brain cells; researchers say the discovery in rats could potentially lead to the development of a new class of non-invasive therapies for neurological disorders.

24 Feb 2022

Translation News and Research

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

How does the non-structural protein 1 affect COVID-19 pathogenicity?

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Novel mathematical model could predict the evolutionary trend of SARS-CoV-2

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Researchers find unusual way of stabilizing cancer-suppressing protein

CR Forum to honor Cleveland Clinic researcher with a 2022 Top Ten Clinical Research Achievement Award

Potent pan-β-CoV human monoclonal antibody has in vivo activity in multiple animal models

A new view of SARS-CoV-2 genome structure

Slowing down the DNA replication speed increases cell reprogramming efficiency

New treatment strategy makes pancreatic tumors sensitive to immunotherapy, mice study shows

Diabetes and the mTOR pathway in COVID-19 patients

Study shows targeting DDX3 with RK-33 reduced the viral load in four isolates of SARS-CoV-2

Assessing the potential of IFNa subtypes in suppressing SARS-CoV-2

Triple drug regimen proven effective against non-structural protein-1 of SARS-CoV-2

Intestinal cells can change specializations during their lives, finds study

A ubiquitous protein may be key to the survival of neurons most impacted by glaucoma

SARS-CoV-2 protein interactions with viral and host RNAs in authentic virus-infected cells

Recombinant adenovirus vector vaccine generates mucosal antibodies against SARS-CoV-2

Pioneering technique uses a magnetic device to stimulate touch sensitive brain glial cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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