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MannKind Corporation submits NDA for Afresa for treatment of diabetes

MannKind Corporation has announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) requesting approval of Afresa (insulin monomer human [rDNA origin]) Inhalation Powder and the Afresa Inhaler for the treatment of adults with type 1 or type 2 diabetes mellitus for the control of hyperglycemia.

16 Mar 2009

Immune cells play surprising role in cystic fibrosis lung damage

Immune cells once thought to be innocent bystanders in cystic fibrosis may hold the key to stopping patients' fatal lung disease.

16 Mar 2009

Colon cancer screenings recommended at 45 for African Americans

According to the American Cancer Society, there were about 108,070 new cases of colon cancer and 40,740 new cases of rectal cancer in 2008. Overall, the two cancers caused nearly 50,000 deaths last year.

16 Mar 2009

New approach to prevent bacterial infections from taking hold

Dr Quinn Parks and colleagues describe how they used enzymes against products of the body's own defence cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm which enables them to avoid both the body's immune mechanisms and antibiotics.

15 Mar 2009

Treatment of European coronary patients fails to meet standards of international guidelines

Large proportions of European coronary patients are failing to achieve lifestyle, risk factor and therapeutic targets for the prevention of further disease, according to results of the third EUROASPIRE survey.

12 Mar 2009

Biothera receives approval to launch two lung cancer trials

German regulatory authorities have granted approval to Biothera to conduct two open label, multicenter, randomized Phase II clinical trials studying Imprime PGGÂ® administered in combination with monoclonal antibodies and chemotherapy in patients with non-small cell lung cancer (NSCLC), the company announced today.

12 Mar 2009

Oncolytics Biotech (TSX:ONC, NASDAQ:ONCY) starts U.S. enrolment in trial for non-small cell lung cancer patients

Oncolytics Biotech Inc. has announced that it has started patient enrolment in a Phase 2 clinical trial using intravenous administration of Reolysin in combination with paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC) with K-RAS or EGFR-activated tumours.

12 Mar 2009

New project to develop blood tests for heart disease and stroke

The landmark Framingham Heart Study (FHS) is launching a major initiative to discover risk factors and markers that could lead to new blood tests to identify individuals at high risk of heart disease and stroke.

12 Mar 2009

Estrogen activates critical lung genes to improve lung function following preterm birth

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants, researchers at UT Southwestern Medical Center have found in an animal study.

12 Mar 2009

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants

"Ironically, a hormone that has received great attention as a potential means to optimize the health of older women may be a beneficial treatment for humans during the earliest stages of life," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author.

12 Mar 2009

Research shed new light on anergia

With the help of a non-invasive method of monitoring human activity, doctors and researchers at Columbia University Medical Center are shedding new light on a syndrome affecting nearly 40 percent of older adults with heart failure: anergia.

11 Mar 2009

Long-term ground ozone exposure increases risk of dying from lung disease

Long-term exposure to elevated levels of ground ozone - a major constituent of smog - significantly raises the risk of dying from lung disease, according to a new nationwide study of cities that evaluated the impact of ozone on respiratory health over an 18-year period.

11 Mar 2009

Smokers' chronic obstructive pulmonary disease risk is genetic

It's well known that puffing on cigarettes can eventually leave you out of puff.

11 Mar 2009

Novel anti-inflammatory therapy protects lungs from runaway inflammation

A novel anti-inflammatory therapy designed by Vanderbilt University Medical Center investigators prevents acute lung injury in mice exposed to an inflammation-causing toxin, the researchers report in the journal Molecular Therapy.

11 Mar 2009

Close relationships can perpetuate health-compromising behaviors

Human problems rarely occur in a vacuum, but persist as part of ongoing social interaction in which causes and effects are interwoven.

11 Mar 2009

Discovery of cellular pathway that prevents cancer response to diet restriction

Whitehead Institute researchers have pinpointed a cellular pathway that determines whether cancerous tumors respond to dietary restriction during their development.

11 Mar 2009

Cell pathway on overdrive prevents cancer response to dietary restriction

Whitehead Institute researchers have pinpointed a cellular pathway that determines whether cancerous tumors respond to dietary restriction during their development.

11 Mar 2009

Small molecules block cancer gene

Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the current online issue of the journal PLoS One (Public Library of Science ONE).

11 Mar 2009

Immune-based therapy approved in Europe for pediatric cancer patients

The European Commission, which oversees legislation and regulation for the European Union, has approved a therapy for pediatric patients with non-metastatic, resectable osteosarcoma, a type of bone cancer.

11 Mar 2009

First 'nano' treatments to target cancer cells

Cancer Research UK scientists have for the first time developed a treatment that transports 'tumour busting' genes selectively to cancer cells, according to a study published online in Cancer Research.

11 Mar 2009