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Radiolabeled hedgehog can differentiate stem-like cancer cells, identify aggressive tumors

At the American Association for Cancer Research 101st Annual Meeting 2010, scientists and clinicians will present more than 6,300 abstracts dealing with innovative aspects of biology, technology and emerging therapies.

19 Apr 2010

Teen drinking increases the risk for breast cancer

What are the chances of you developing breast cancer if you have been drinking alcohol regularly as a teenager? Very high indeed as per the findings of a study called “Growing Up Today” conducted on 6,899 women from the time they were 9 to 15 year old till they turned 18 to 27 years old.

18 Apr 2010

Pre-clinical data on MM-121 and MM-111 to be presented at AACR 2010

Merrimack Pharmaceuticals, Inc. announced today that it will present pre-clinical data on MM-121 and MM-111, the two lead candidates in the company's pipeline of five novel cancer antibodies, at the 101st Annual Meeting of the American Association for Cancer Research (AACR) being held April 17 – 21, 2010, in Washington, D.C.

17 Apr 2010

700 scientists to present new information on smell and taste at AChemS 32nd annual meeting

The Association for Chemoreception Sciences (AChemS), a US-based scientific organization, is holding its 32nd annual meeting. About 700 scientists are gathering to present new information on the role of smell and taste in disease, nutrition and social interactions in humans as well as animals. Smell and taste play essential roles in our daily lives. These chemical senses serve as important warning systems, alerting us to the presence of potentially harmful situations or substances, including gas leaks, smoke, and spoiled food.

17 Apr 2010

Researchers discover link between protein structure and hearing process

Rising from the top surface of each of the specialized receptor cells in our inner ears is a bundle of sensory cilia that responds to the movement of sound. As sensitive as they are fragile, these cilia can move to wisps of sound no larger than a molecule-but can shear at sounds that are larger than life.

17 Apr 2010

Research reveals TRPV3 protein as potential new drug target for cancer and skin disorders

New findings about a temperature sensor in the skin could lead to novel approaches to controlling excess hair growth and treating skin cancers.

16 Apr 2010

International study evaluates new class of drugs for treating primary biliary cirrhosis

Results of a study presented today at the at the International Liver CongressTM 2010 reveals the effects of a new drug for the treatment of primary biliary cirrhosis, and shows further evaluation is necessary.

16 Apr 2010

Positive interim data from Idera Pharmaceuticals' Phase 1 trial of IMO-2125 TLR9 agonist presented at 45th EASL

Idera Pharmaceuticals, Inc. announced today that positive interim data from a Phase 1 clinical trial of IMO-2125, a Toll-like Receptor 9 (TLR9) agonist, in null responder patients with chronic hepatitis C virus (HCV) infection were presented at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL).

16 Apr 2010

New research identifies cellular channel that regulates skin and hair growth

Skin and hair follicles are constantly renewed in the body, maintained by specialized stem cells. New research from Children's Hospital Boston identifies a small cellular channel that regulates skin and hair growth and that could be targeted with small-molecule drugs, potentially treating variety of skin conditions, as well as thinning hair or unwanted hair growth. Findings appear in the April 16, 2010 issue of Cell.

16 Apr 2010

eRNA molecules are key players in brain development, says study

How does the brain work? This question is one of the greatest scientific mysteries, and neurobiologists have only recently begun to piece together the molecular building blocks that enable human beings to be "thinking" animals.

15 Apr 2010

Synergistic interactions of A2A Agonist and PDE Inhibitors as adjunctive therapy to GC for treating MM

“Glucocorticoids are a key component of combination therapy regimens in multiple myeloma and other hematological cancers. However, glucocorticoid use comes with substantial dose limiting toxicities. The ability to enhance glucocorticoid dependent effects while sparing associated toxicities may have important implications for the treatment of multiple myeloma and other B-cell malignancies”

15 Apr 2010

Targeted therapy MDV3100 is effective for patients with CRPC: Study

An experimental drug is showing promise for the treatment of men with an aggressive form of advanced prostate cancer. A new multicenter study has concluded that the targeted therapy MDV3100 is safe and effective for patients with castration-resistant prostate cancer, known for its poor prognosis and limited treatment options.

15 Apr 2010

Synosia Therapeutics presents data from phase 2a clinical study of SYN-115 in PD

Synosia Therapeutics today announced the presentation of data from a phase 2a clinical study of the company's adenosine 2a receptor antagonist (SYN-115) in Parkinson's disease. The data demonstrate that SYN-115 significantly improves measures of motor and non-motor function in patients with Parkinson's disease either alone or in combination with levodopa.

15 Apr 2010

Research team to receive AACR Team Science Award

The fourth annual American Association for Cancer Research Team Science Award will be given to Dana-Farber/Harvard Cancer Center Thoracic Oncology Research Team at the AACR 101st Annual Meeting 2010. This research team is comprised of interdisciplinary investigators from the Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School.

15 Apr 2010

Breast Cancer Research: Thinner girls may be at higher risk of breast cancer

Thinner girls may be at higher risk of breast cancer. Researchers writing in BioMed Central's open access journal Breast Cancer Research found that girls who were leaner at age seven were at higher risk of cancer later in life.

15 Apr 2010

Trevena commences Phase I trial of TRV120027 biased ligand for acute decompensated heart failure

Trevena Inc., a leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, today announced the initiation of a Phase I clinical trial of TRV120027, a titratable i.v. agent designed for the treatment of acute decompensated heart failure. TRV120027 is a biased ligand that targets the angiotensin II type 1 receptor (AT1R) and induces a unique mode of signaling.

15 Apr 2010

Study identifies pathway linked to rheumatoid arthritis

Investigators from Hospital for Special Surgery have identified a pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis. The finding, reported in the April 23 issue of the journal Immunity, could lead to the development of new therapeutic approaches to treating arthritis in the future.

13 Apr 2010

Researchers invent zinc-stapled insulin to reduce insulin-related cancer risk

For millions of Americans with Type-2 diabetes and inject insulin to control diabetes (with onset typically in adulthood) the associated risk of cancer is of increasing concern. Studies have demonstrated that obesity and excess insulin - whether naturally produced by the body or injected in synthetic form - are associated with an increased incidence of some common cancers.

13 Apr 2010

Researchers may be one step closer to slowing the progression of Alzheimer's disease

Researchers may be one step closer to slowing the onset and progression of Alzheimer's disease. An animal study supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health, shows that by targeting the blood-brain barrier, researchers are able to slow the accumulation of a protein associated with the progression of the illness.

13 Apr 2010

Stress hormones may suppress tumor growth: Study

Chronic stress triggers a chain of molecular events that protects breakaway ovarian cancer cells from destruction, a team of researchers led by scientists at The University of Texas M. D. Anderson Cancer Center reports April 12 in the early online publication of the Journal of Clinical Investigation.

13 Apr 2010

Receptor News and Research

Radiolabeled hedgehog can differentiate stem-like cancer cells, identify aggressive tumors

Teen drinking increases the risk for breast cancer

Pre-clinical data on MM-121 and MM-111 to be presented at AACR 2010

700 scientists to present new information on smell and taste at AChemS 32nd annual meeting

Researchers discover link between protein structure and hearing process

Research reveals TRPV3 protein as potential new drug target for cancer and skin disorders

International study evaluates new class of drugs for treating primary biliary cirrhosis

Positive interim data from Idera Pharmaceuticals' Phase 1 trial of IMO-2125 TLR9 agonist presented at 45th EASL

New research identifies cellular channel that regulates skin and hair growth

eRNA molecules are key players in brain development, says study

Synergistic interactions of A2A Agonist and PDE Inhibitors as adjunctive therapy to GC for treating MM

Targeted therapy MDV3100 is effective for patients with CRPC: Study

Synosia Therapeutics presents data from phase 2a clinical study of SYN-115 in PD

Research team to receive AACR Team Science Award

Breast Cancer Research: Thinner girls may be at higher risk of breast cancer

Trevena commences Phase I trial of TRV120027 biased ligand for acute decompensated heart failure

Study identifies pathway linked to rheumatoid arthritis

Researchers invent zinc-stapled insulin to reduce insulin-related cancer risk

Researchers may be one step closer to slowing the progression of Alzheimer's disease

Stress hormones may suppress tumor growth: Study

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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