Efficacy News and Research

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Phase 1b study of olesoxime initiated in multiple sclerosis (MS) patients

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14 Mar 2013

Steroids used for treating TB may reduce death rates from all types of TB

The routine use of steroids to treat tuberculosis may help reduce deaths from all types of the disease, according to a new review of existing research.

14 Mar 2013

Pre-treatments for peripheral neuropathic pain patch receive European Commision approval

The European Commission (EC) has approved expanded options for pre-treatment prior to use of QUTENZA (8% capsaicin patch). Before application the patient may now take an oral analgesic, or the treatment area may be pre-treated with a topical anaesthetic.1 The 8% capsaicin patch is the first and only licensed high concentration (8%) capsaicin cutaneous patch for the treatment of peripheral neuropathic pain in Europe.

14 Mar 2013

Scientists sign licensing agreement for anticancer substances

Most cancer patients die of the disease because tumor cells spread to other sites in the body and form new tumors, so-called metastases.

14 Mar 2013

Study: Treatment of obstructive sleep apnea no worse in primary care vs specialist sleep center

Among patients who were identified as likely having moderate to severe obstructive sleep apnea, treatment based in primary care was not clinically inferior to treatment at a specialist sleep center for improvement in daytime sleepiness scores, according to a study appearing in the March 13 issue of JAMA.

14 Mar 2013

Trans-Pacific Partnership (TPP) Agreement: an interview with Judit Rius, Médecins Sans Frontières

The Trans-Pacific Partnership (TPP) is a trade deal currently being negotiated between eleven countries of the Asia-Pacific region: Australia, Brunei Darussalam, Canada, Chile, Malaysia, Mexico, New Zealand, Peru, United States, Singapore and Vietnam.

12 Mar 2013

Lithera commences LIPO-202 Phase 2b trial for reduction of subcutaneous fat

Lithera, Inc., a clinical stage pharmaceutical company focused on lifestyle and medical indications in aesthetic medicine and ophthalmology, announced today that the first patient has been treated with LIPO-202 (Salmeterol Xinafoate for Injection) in its 500-patient Phase 2b "RESET" trial.

12 Mar 2013

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

The experimental anti-clotting drug cangrelor solidly outperformed commonly used clopidogrel in a large global trial of patients who underwent coronary stent procedures, according to data from the phase III CHAMPION PHOENIX study presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Among patients hospitalized for heart failure (HF) with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction), initiation of the medication aliskiren in addition to standard therapy did not reduce cardiovascular death or HF rehospitalization at 6 or 12 months after discharge, according to a study published online by JAMA.

12 Mar 2013

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

Antibodies and in the case of Ablynx, Nanobodies, can be raised and selected to bind with high affinity selectively to cancer cells in a tumour. Cancer cells are exquisitely sensitive to certain toxins such as the PBDs produced by Spirogen.

12 Mar 2013

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center.

12 Mar 2013

Sosei commences SO-1105 Phase III trial in oropharyngeal candidiasis

Sosei Group Corporation, the biopharmaceutical company, today announces that its Japanese subsidiary, Sosei Co., Ltd., has initiated a Phase III trial for SO-1105 for the treatment of oropharyngeal candidiasis.

12 Mar 2013

Cell phone microscope can detect intestinal worm infections in children

Scientists working in rural Tanzania have used a simple US$8 glass lens, a strip of double-sided tape, and a cheap flashlight to convert an Apple iPhone into a field microscope that can successfully detect intestinal worm infections in children, according to a study published online today by the American Journal of Tropical Medicine and Hygiene.

12 Mar 2013

On and off-pump coronary artery bypass surgery equally safe, effective for older patients

Older patients did as well after undergoing coronary bypass surgery off-pump as they did with the more costly "on-pump" procedure using a heart-lung machine to circulate blood and oxygen through the body during surgery, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

12 Mar 2013

FlexToBa program can enhance health of older adults

Fitness DVDs are a multimillion-dollar business, and those targeting adults over the age of 55 are a major part of the market. With names like "Boomers on the Move," "Stronger Seniors" and "Ageless Yoga," the programs promise much, but few have ever been rigorously tested.

12 Mar 2013

DSMB recommends discontinuation of Aeterna Zentaris’ perifosine Phase 3 study for MM

Aeterna Zentaris Inc. today announced that an independent Data Safety Monitoring Board has recommended discontinuing the ongoing Phase 3 study comparing the efficacy and safety of perifosine to placebo when combined with bortezomib (Velcade) and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma.

12 Mar 2013

Influenza drug: an interview with Dr Jenny McKimm-Breschkin, CSIRO

Influenza or flu for short is caused by a family of viruses, which can be called influenza A or influenza B. Influenza A viruses are found in humans, animals – like swine and horses- and mostly aquatic birds. Influenza B is only found in humans.

11 Mar 2013

Endometrial cancer survivors more likely to complete physical activity

Endometrial cancer survivors are more likely to complete physical activity, and for longer durations, when their daily self-efficacy is higher, according to a study published online in the journal Health Psychology - a publication of the American Psychology Association.

11 Mar 2013

FDA accepts Ampio’s Patient Outcome for Premature Ejaculation questionnaire

Ampio Pharmaceuticals, Inc., a biopharmaceutical company developing drugs to treat prevalent inflammatory diseases, such as osteoarthritis (Ampion) and diabetic macular edema (Optina) and sexual dysfunction (Zertane) announced FDA acceptance of its POPE questionnaire, a modification of the Premature Ejaculation Profile (PEP) questionnaire that was used in the two successful Zertane Phase 3 clinical trials completed in Europe.

11 Mar 2013

Combining mitochondrial inhibitors could improve efficacy of BRAF inhibitors in melanoma

A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism.

11 Mar 2013

Efficacy News and Research

Phase 1b study of olesoxime initiated in multiple sclerosis (MS) patients

Steroids used for treating TB may reduce death rates from all types of TB

Pre-treatments for peripheral neuropathic pain patch receive European Commision approval

Scientists sign licensing agreement for anticancer substances

Study: Treatment of obstructive sleep apnea no worse in primary care vs specialist sleep center

Trans-Pacific Partnership (TPP) Agreement: an interview with Judit Rius, Médecins Sans Frontières

Lithera commences LIPO-202 Phase 2b trial for reduction of subcutaneous fat

Cangrelor solidly outperforms clopidogrel during percutaneous coronary intervention

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Anti-cancer drug conjugates: an interview with Dr Andreas Menrad, CSO Ablynx and Dr Chris Martin, CEO Spirogen

NIH-sponsored comparative trial evaluates benefits of combination therapy and monotherapy in MS

Sosei commences SO-1105 Phase III trial in oropharyngeal candidiasis

Cell phone microscope can detect intestinal worm infections in children

On and off-pump coronary artery bypass surgery equally safe, effective for older patients

FlexToBa program can enhance health of older adults

DSMB recommends discontinuation of Aeterna Zentaris’ perifosine Phase 3 study for MM

Influenza drug: an interview with Dr Jenny McKimm-Breschkin, CSIRO

Endometrial cancer survivors more likely to complete physical activity

FDA accepts Ampio’s Patient Outcome for Premature Ejaculation questionnaire

Combining mitochondrial inhibitors could improve efficacy of BRAF inhibitors in melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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