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Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Armetheon, Inc., a clinical stage biopharmaceutical company, announced today that it plans to develop its novel oral anti-coagulant (OAC), tecarfarin (ATI-5923), for a patient population which includes those who have prosthetic heart valves or chronic renal dysfunction.

11 Mar 2013

Investigational treatment for ulcerative colitis (UC) and Crohn’s disease (CD) has Marketing Authorisation Application submitted

Takeda Pharmaceutical Company Limited (“Takeda”) today announced that a Marketing Authorisation Application (MAA) has been submitted to The European Medicines Agency (EMA) for vedolizumab, an investigational, gut-selective humanized monoclonal antibody for the treatment of adults with moderately to severely active ulcerative colitis (UC) and Crohn’s disease (CD), the two most common types of inflammatory bowel disease (IBD).

8 Mar 2013

Halometasone and fusidic acid optimal for infected eczema

Results from a randomized, open-label phase III trial suggest that a combination cream of halometasone and fusidic acid reduces symptoms of eczema to a similar degree to a betamethasone and neomycin sulphate cream, but is more effective at treating infected lesions.

8 Mar 2013

Chronic obstructive pulmonary disease (COPD) inflammatory subtypes: an interview with Dr Vanessa McDonald, University of Newcastle, Australia

COPD is defined as a preventable and treatable disease associated with significant extrapulmonary consequences that may contribute to severity. The pulmonary component of COPD is characterised by airflow limitation that is not fully reversible. The airflow limitation is usually progressive with an abnormal inflammatory response of the lungs to noxious particles (GOLD Strategy Document). Airflow obstruction in COPD is not highly variable and largely irreversible.

8 Mar 2013

Study shows reduction of brain capillaries in mice immunized with amyloid beta

University of British Columbia researchers have successfully normalized the production of blood vessels in the brain of mice with Alzheimer's disease (AD) by immunizing them with amyloid beta, a protein widely associated with the disease.

8 Mar 2013

ADMA Biologics initiates enrollment in RI-002 Phase III study for PIDD

ADMA Biologics, Inc. (ADMA), a specialty immune globulin company that develops, manufactures and intends to market plasma-based biologics for the treatment and prevention of certain infectious diseases, announced that the first patient enrolled in the pivotal Phase III clinical study of its RI-002 has been dosed.

7 Mar 2013

Treating substance abuse alone helps patients with co-occurring psychosis

Patients with co-occurring substance use disorder and psychiatric disorders may benefit from standard substance use disorder treatment, with the effects potentially lasting for several years, the results of a US study indicate.

7 Mar 2013

FDA accepts AMAG’s Feraheme sNDA for review

AMAG Pharmaceuticals, Inc. today announced that the United States Food and Drug Administration (FDA) has accepted for review the company's supplemental new drug application (sNDA) for Feraheme (ferumoxytol) Injection for Intravenous (IV) use, which was submitted to the FDA in December 2012.

6 Mar 2013

Fewer malaria cases, more artesunate resistance on Thai border

Results from an observational study show that the number of reported malaria cases in children and pregnant women on the Thai–Myanmar border has decreased significantly over the past decade.

6 Mar 2013

Pain self-management and exercise ‘effective in elderly’

Techniques for the self-management of chronic pain based on cognitive behavioral therapy significantly reduce disability, suggest results from a randomized controlled trial in older adults.

6 Mar 2013

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Two brothers have been cured of their sickle cell disease at the University of Illinois Hospital & Health Sciences System using a relatively uncommon type of stem cell transplant that is performed without chemotherapy.

6 Mar 2013

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

Researchers have identified a critical protein role in the metastasis of melanoma, the most serious form of skin cancer.

6 Mar 2013

New research findings could lead to development of effective therapies for anxiety disorders

Researchers at Boston University School of Medicine have, for the first time, identified a specific group of cells in the brainstem whose activation during rapid eye movement sleep is critical for the regulation of emotional memory processing.

6 Mar 2013

Continuous dyskinesia monitoring technology for Parkinson’s to be developed by Great Lakes NeuroTechnologies

Great Lakes NeuroTechnologies (GLNT) announced today that they are launching commercialization and clinical studies to validate a system for objective, continuous monitoring of dyskinesias associated with Parkinson’s disease.

5 Mar 2013

FES cycling associated with improvements in individuals with chronic spinal cord injury

A new study by Kennedy Krieger Institute's International Center for Spinal Cord Injury finds that long-term lower extremity functional electrical stimulation (FES) cycling, as part of a rehabilitation regimen, is associated with substantial improvements in individuals with chronic spinal cord injury (SCI).

5 Mar 2013

Mirabegron reduces frequency of incontinence episodes in phase III trial

In a new phase III trial mirabegron, a β3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder compared to those in a placebo group.

5 Mar 2013

Sanford-Burnham enters into partnership to test furin for treatment of dengue fever

Sanford-Burnham Medical Research Institute and 60- Pharmaceuticals, LLC, have entered into a partnership to test furin, a human proteinase, as a drug target for the treatment of dengue fever, one of the most common infectious diseases in the tropics and subtropics.

5 Mar 2013

Study finds antiretroviral-based strategies to prevent HIV infection among women prove ineffective

Three antiretroviral-based strategies intended to prevent HIV infection among women did not prove effective in a major clinical trial in Africa.

5 Mar 2013

HCV and HIV co-infected patients achieve early treatment success with faldaprevir, PegIFN/RBV

Interim study results from STARTversoTM 4 presented today at CROI+ show that 80 percent of hepatitis C (HCV) patients also infected with HIV achieved early treatment success with faldaprevir (BI 201335) combined with pegylated interferon and ribavirin (PegIFN/RBV).

5 Mar 2013

Screening colonoscopy associated with reduced advanced colorectal cancer diagnoses

A new study led by a researcher at the Perelman School of Medicine at the University of Pennsylvania adds support to current medical recommendations stating that screening colonoscopy substantially reduces an average-risk adult's likelihood of being diagnosed with advanced colorectal cancer (CRC) in either the right or left side of the colon.

4 Mar 2013

Efficacy News and Research

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Investigational treatment for ulcerative colitis (UC) and Crohn’s disease (CD) has Marketing Authorisation Application submitted

Halometasone and fusidic acid optimal for infected eczema

Chronic obstructive pulmonary disease (COPD) inflammatory subtypes: an interview with Dr Vanessa McDonald, University of Newcastle, Australia

Study shows reduction of brain capillaries in mice immunized with amyloid beta

ADMA Biologics initiates enrollment in RI-002 Phase III study for PIDD

Treating substance abuse alone helps patients with co-occurring psychosis

FDA accepts AMAG’s Feraheme sNDA for review

Fewer malaria cases, more artesunate resistance on Thai border

Pain self-management and exercise ‘effective in elderly’

Chemotherapy-free stem cell transplant shows promise for sickle cell disease

Targeting ARF6 may be effectively prevent melanoma metastasis to lungs

New research findings could lead to development of effective therapies for anxiety disorders

Continuous dyskinesia monitoring technology for Parkinson’s to be developed by Great Lakes NeuroTechnologies

FES cycling associated with improvements in individuals with chronic spinal cord injury

Mirabegron reduces frequency of incontinence episodes in phase III trial

Sanford-Burnham enters into partnership to test furin for treatment of dengue fever

Study finds antiretroviral-based strategies to prevent HIV infection among women prove ineffective

HCV and HIV co-infected patients achieve early treatment success with faldaprevir, PegIFN/RBV

Screening colonoscopy associated with reduced advanced colorectal cancer diagnoses

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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