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Patients with soft-tissue cancer show rapid and complete response to novel combination of immunotherapy

A patient with end-stage and rapidly progressing soft-tissue cancer whose tumor did not respond to standard treatment, had a "rapid and complete response" to a novel combination of immunotherapy, according to new research published by a team of scientists from John Theurer Cancer Center at Hackensack University Medical Center and the Georgetown Lombardi Comprehensive Cancer Center, both of whom are part of the Georgetown Lombardi Comprehensive Cancer Center Consortium.

16 Oct 2020

Scientists discover a novel antiviral strategy for treating COVID-19

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19.

16 Oct 2020

Rapid development of functionally diverse SARS-COV-2 mouse monoclonal antibodies

Now, a recent study published on the preprint server bioRxiv in October 2020 reports the development of a rapid process for generating high-affinity mouse mAbs, and their functional attributes.

16 Oct 2020

Exposure to ancient parasites may be linked to humans’ response to coronavirus

Why are some people more resilient to viruses than others? The answer has eluded scientists for centuries and, in the age of COVID-19, has come to represent one of the holy grails of biomedical research.

16 Oct 2020

Synthetic signals could help control tissue regeneration, guide cellular therapies

For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.

16 Oct 2020

Scientists reveal host pathways hijacked by three lethal coronaviruses

Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three.

16 Oct 2020

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

The COVID-19 pandemic is threatening to come back in greater intensity during the winter and fall. Faced with this threat, vaccine development efforts are entering a phase of renewed focus, attempting to identify antigens capable of eliciting protective levels of neutralizing antibodies. A new study published on the preprint server bioRxiv* in October 2020 reports on a novel mRNA vaccine candidate's performance in two animal models.

16 Oct 2020

UofSC scientists identify biological triggers that promote quicker nerve regeneration

University of South Carolina scientists are exploring ways to make nerve regeneration happen faster and more successfully.

15 Oct 2020

Glutathione precursor improves multiple deficits associated with premature aging

Premature aging in people with HIV is now recognized as a new, significant public health challenge. Accumulating evidence shows that people with HIV who are between 45 to 60 years old develop characteristics typically observed in people without HIV that are more than 70 years of age.

15 Oct 2020

Start-up receives NIH grant to accelerate development of contrast agent to detect liver fibrosis

Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents' Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver disease.

15 Oct 2020

NIH grants 4D Nucleome award to support research by Gladstone scientists

The National Institutes of Health has granted a 4D Nucleome award to support research by a group of scientists at Gladstone Institutes led by Benoit Bruneau, PhD, and Katie Pollard, PhD.

15 Oct 2020

UTHSC professor receives $2.2 million for research into arterial stiffness and hypertension

In humans, large arteries lose elasticity and thicken with age and other pathological conditions, leading to arteriosclerosis and high blood pressure.

15 Oct 2020

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Researchers identify circulating proteins influencing COVID-19 susceptibility and severity by employing a large-scale two-sample Mendelian randomization (MR) study.

15 Oct 2020

Moffitt study uncovers how specific molecules promote cancer progression

The development of cancer is a highly complicated process, involving multiple genes and signaling pathways that become upregulated or downregulated throughout different stages of tumor growth and spread.

15 Oct 2020

New technology precisely diagnoses sickle cell disease in a minute

Researchers at the University of Colorado Boulder and the University of Colorado Anschutz Medical Campus have developed a new way to diagnose diseases of the blood like sickle cell disease with sensitivity and precision and in only one minute.

15 Oct 2020

Blood purification outside the body in COVID-19 patients

Rodney Rosalia et al., in a recent medRxiv preprint research paper, study the longitudinal variation of parameters involved with systemic inflammation in critically ill COVID-19 patients upon EBP treatment.

15 Oct 2020

Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

In a recent paper available on the bioRxiv preprint server, US researchers show that individual particles of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergo structural destabilization at relatively mild but elevated temperatures – strengthening the case for coronavirus disease (COVID-19) resurgence in the winter.

15 Oct 2020

Small RNA molecule controls major pathogenicity factors of H. pylori

More than half of the world's population carries the bacterium Helicobacter pylori in their stomach mucosa. It often causes no problems throughout life, but sometimes it can cause inflammation, and in some cases, it can even lead to the development of stomach cancer.

15 Oct 2020

Experts to address factors that cause low dairy consumption in low- and middle-income countries

Low dairy consumption is common among low- and middle-income countries (LMICs); however, with the demand for milk in these countries projected to increase over the next few decades, there is an opportunity to improve the lives of millions of people from the nutritional benefits of dairy products.

15 Oct 2020

Common kidney tests can help estimate risk of cardiovascular disease

Taking into account two common kidney disease tests may greatly enhance doctors' abilities to estimate patients' cardiovascular disease risks, enabling millions of patients to have better preventive cardiovascular care, according to a large international study co-led by researchers at the Johns Hopkins Bloomberg School of Public Health.

15 Oct 2020

Protein C News and Research

Patients with soft-tissue cancer show rapid and complete response to novel combination of immunotherapy

Scientists discover a novel antiviral strategy for treating COVID-19

Rapid development of functionally diverse SARS-COV-2 mouse monoclonal antibodies

Exposure to ancient parasites may be linked to humans’ response to coronavirus

Synthetic signals could help control tissue regeneration, guide cellular therapies

Scientists reveal host pathways hijacked by three lethal coronaviruses

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

UofSC scientists identify biological triggers that promote quicker nerve regeneration

Glutathione precursor improves multiple deficits associated with premature aging

Start-up receives NIH grant to accelerate development of contrast agent to detect liver fibrosis

NIH grants 4D Nucleome award to support research by Gladstone scientists

UTHSC professor receives $2.2 million for research into arterial stiffness and hypertension

Mendelian randomization helps evaluate impact of circulating proteins in COVID-19

Moffitt study uncovers how specific molecules promote cancer progression

New technology precisely diagnoses sickle cell disease in a minute

Blood purification outside the body in COVID-19 patients

Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

Small RNA molecule controls major pathogenicity factors of H. pylori

Experts to address factors that cause low dairy consumption in low- and middle-income countries

Common kidney tests can help estimate risk of cardiovascular disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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