DNA Sequencing News and Research

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Findings may yield novel therapeutic strategies for late-stage breast cancer

Researchers from the Boston University School of Medicine (BUSM) have determined how the TGFβ-Smad signaling pathway, which is over activated in late-stage cancers, is responsible for the "epigenetic memory" that maintains unique patterns of regulatory DNA hypermethylation causing silencing of critical genes that facilitate breast cancer progression.

25 Jan 2010

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

Research on the genetic defect that causes myotonic muscular dystrophy has revealed that the mutation disrupts an array of metabolic pathways in muscle cells through its effects on two key proteins.

24 Jan 2010

Researchers show how MRSA transmission can be tracked in hospital settings

For the first time, researchers have shown how transmission of MRSA from one person to another can be precisely tracked in a hospital setting. The team have developed a remarkable new method that can 'zoom' from large-scale inter-continental transmission events to the much finer detail of person-to-person infection of MRSA within a single hospital.

22 Jan 2010

Scientists discover new mechanism that explains role of EBV in tumor growth

The Epstein-Barr virus (EBV), a virus of the herpes family, has two distinct life phases: After infecting a cell it first goes into a resting phase. Under certain circumstances the virus can become active - and then induces tumor growth or promotes its synthesis in the cell.

18 Jan 2010

Research reveals gene activation is linked to most aggressive type of brain cancer

Glioblastoma (GBM), the brain cancer better known for having killed Senator Ted Kennedy a few months ago, is the most aggressive and lethal of all brain tumours.

18 Jan 2010

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

A $1 million grant from Abraxis Bioscience, Inc. to a world-famous research laboratory at John Wayne Cancer Institute at Saint John’s Health Center could help save lives of cancer patients by helping doctors more rapidly assess whether a treatment is working or not.

12 Jan 2010

NetApp, Stanford Genome Technology Center build gastric cancer registry powered by NetApp storage technology

Gastric cancer is the number two cancer killer worldwide and one of the top cancer killers in the U.S., but gastric cancer research gets the least federal funding of any type of cancer research. According to a CBS News analysis of data released by the American Cancer Society, for every cancer-related death in the U.S., only $1,168 federal research dollars are spent on gastric cancer, versus $18,870 for cancer of the cervix and $14,095 for breast cancer.

12 Jan 2010

Scientists identify gene underlying a disease that causes temporary paralysis of skeletal muscle

Scientists have identified a gene underlying a disease that causes temporary paralysis of skeletal muscle. The finding, they say, illustrates how investigations of rare genetic diseases can drive insights into more common ones.

8 Jan 2010

Epigenetic diagnosis and therapies, a new strategy for treating cancer

A tumor's genetic profile is often useful when diagnosing and deciding on treatment for certain cancers, but inexplicably, genetically similar leukemias in different patients do not always respond well to the same therapy.

7 Jan 2010

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

A collaboration between the University of Massachusetts Medical School, the Cummings School of Veterinary Medicine at Tufts University and the Broad Institute at the Massachusetts Institute of Technology has identified a genetic locus on canine chromosome 7 which coincides with an increased risk of obsessive compulsive disorder (OCD) susceptibility.

7 Jan 2010

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Agilent Technologies, Inc. (NYSE:A) and Covaris Inc. today announced a co-marketing agreement in which Covaris S2 DNA shearing technology will be marketed with the Agilent SureSelect Target Enrichment System to streamline next-generation sequencing experiments.

6 Jan 2010

Carbon nanotube: A viable alternative for rapid DNA sequencing

Faster sequencing of DNA holds enormous potential for biology and medicine, particularly for personalized diagnosis and customized treatment based on each individual's genomic makeup.

4 Jan 2010

Test tube experiments show slight changes in protein chemistry can eliminate Huntington's disease in mice

In Huntington's disease, a mutated protein in the body becomes toxic to brain cells. Recent studies have demonstrated that a small region adjacent to the mutated segment plays a major role in the toxicity. Two new studies supported by the National Institutes of Health show that very slight changes to this region can eliminate signs of Huntington's disease in mice.

28 Dec 2009

Scientists use DNA sequence to characterize genome rearrangement in breast cancer samples

The first detailed search of breast cancer genomes to uncover genomic rearrangements is published today. The team characterised the ways in which the human genome is broken and put back together in 24 cases of breast cancer.

23 Dec 2009

TessArae's RM-Flu test granted FDA EUA

TessArae, LLC, a privately held company, and Affymetrix Inc., (NASDAQ:AFFX) today announced that the Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) to TessArae for its TessArray® Resequencing Influenza A Microarray Detection Panel for the Detection of the 2009 H1N1 Influenza A Virus (TessArray RM-Flu test) for the duration of the declaration of emergency unless revoked earlier. The declaration of emergency will expire on April 26, 2010, unless terminated earlier or renewed.

21 Dec 2009

Advances in DNA-sequencing technology help identify your personal genome

What secrets about your risk for diseases are written in your own personal "Book of Life" - the 30,000 or so genes that make you you? Advances in DNA-sequencing technology are bringing closer the day when it will be more economical for consumers to get an answer to that question, and others, by ordering up the deciphering of their entire genetic endowment - their "personal genome."

17 Dec 2009

Next-generation DNA sequencing demonstrates potential in identifying mutations in SCLC

Applied Biosystems, part of Life Technologies Corporation, today announced the publication of a paper in the journal Nature that demonstrates the power of next-generation DNA sequencing used to identify DNA mutations in a small cell lung cancer (SCLC) line and identify the mutational burden associated with tobacco smoking.

17 Dec 2009

Typical smoker acquires one mutation for every 15 cigarettes and all cancers are caused by mutations

Research teams led by the Wellcome Trust Sanger Institute announce the first comprehensive analyses of cancer genomes.

17 Dec 2009

Researchers discover new gene involved in lung cancer using DNA sequencing technology

Aided by next-generation DNA sequencing technology, an international team of researchers has gained insights into how more than 60 carcinogens associated with cigarette smoke bind to and chemically modify human DNA, ultimately leading to cancer-causing genetic mutations.

17 Dec 2009

Study may lead to improved, targeted therapies for cancer patients

A team of Princeton University scientists has produced a systematic listing of the ways a particular cancerous cell has "gone wrong," giving researchers a powerful tool that eventually could make possible new, more targeted therapies for patients.

11 Dec 2009

DNA Sequencing News and Research

Findings may yield novel therapeutic strategies for late-stage breast cancer

Loss of key proteins may account for molecular abnormalities associated with myotonic dystrophy

Researchers show how MRSA transmission can be tracked in hospital settings

Scientists discover new mechanism that explains role of EBV in tumor growth

Research reveals gene activation is linked to most aggressive type of brain cancer

Abraxis Bioscience awards John Wayne Cancer Institute $1M grant for identifying new cancer biomarkers

NetApp, Stanford Genome Technology Center build gastric cancer registry powered by NetApp storage technology

Scientists identify gene underlying a disease that causes temporary paralysis of skeletal muscle

Epigenetic diagnosis and therapies, a new strategy for treating cancer

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Carbon nanotube: A viable alternative for rapid DNA sequencing

Test tube experiments show slight changes in protein chemistry can eliminate Huntington's disease in mice

Scientists use DNA sequence to characterize genome rearrangement in breast cancer samples

TessArae's RM-Flu test granted FDA EUA

Advances in DNA-sequencing technology help identify your personal genome

Next-generation DNA sequencing demonstrates potential in identifying mutations in SCLC

Typical smoker acquires one mutation for every 15 cigarettes and all cancers are caused by mutations

Researchers discover new gene involved in lung cancer using DNA sequencing technology

Study may lead to improved, targeted therapies for cancer patients

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