Kinase News and Research

RSS

Study offers novel insights into how a major tumor suppressor pathway becomes deactivated

The Hippo pathway is an important biological tumor suppressor program that controls cell growth and organ size in humans.

5 Apr 2019

Scientists use a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

5 Apr 2019

FDA extends indication of metastatic breast cancer treatment to include male patients

The U.S. Food and Drug Administration today is extending the indication of Ibrance (palbociclib) capsules in combination with specific endocrine therapies for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer in male patients.

5 Apr 2019

New computational model of human kinase may provide insights for cancer drug development

Researchers have developed a computational model for human MEK1, a protein with potential as a drug target for a variety of human cancers.

4 Apr 2019

Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Since 1993, when the gene that causes Huntington's disease was identified, there has been intense focus on understanding how this genetic mutation causes the disease's severe progressive neural deterioration.

4 Apr 2019

Study reveals vitamin B12 as inhibitor of key enzyme in hereditary Parkinson's disease

Iban Ubarretxena, an Ikerbasque Researcher and Director of the Biofisika Institute, participates in a piece of research that has enabled new inhibitors to be identified and which could be used to develop drugs to combat Parkinson's.

3 Apr 2019

Tobacco use causes precancerous cells to 'fertilize' nearby cells with cancerous changes

Tobacco use causes a field of precancerous cells, increasing the risk of developing head & neck cancer. But exactly how this precancerous field influences cancer has been often overlooked.

2 Apr 2019

Research reveals genomic basis of acute erythroid leukemia

Acute erythroid leukemia is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children's Research Hospital that appears today in the journal Nature Genetics.

30 Mar 2019

New targetable vulnerability in breast cancer cells discovered

Researchers at the University of Helsinki and Karolinska Institutet have discovered new molecular mechanisms of breast cancer cell signaling that contribute to aggressive behavior of cancer cells.

29 Mar 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Understanding maintenance of quiescent stem cells in chronic myelogenous leukemia

Most patients with chronic myelogenous leukemia can be treated with tyrosine kinase inhibitors. These drugs are highly effective and lead to deep remission and prolonged survival.

22 Mar 2019

City of Hope receives $7.5 million in grant awards to study cutaneous T cell lymphoma

City of Hope recently received $7.5 million in grant awards to study a rare type of blood cancer that affects the skin: cutaneous T cell lymphoma.

21 Mar 2019

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

Physician-scientists in the Cancer Center at Children's Hospital of Philadelphia have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells.

14 Mar 2019

Researchers develop new molecule that halts progression of heart failure

A group of researchers based in Brazil and the United States have developed a molecule that halts the progression of heart failure and improves the heart's capacity to pump blood.

13 Mar 2019

Parkinson's disease: Servier and Oncodesign announce research and drug development partnership

Servier and Oncodesign have announced a strategic partnership for the research and development of potential drug candidates for Parkinson's disease.

12 Mar 2019

New clinical genomic testing helps identify mutations that drive childhood melanoma

Comprehensive clinical genomic testing of an adolescent patient, including whole genome sequencing, helped researchers identify mutations in a single gene that drive the most common childhood melanoma.

5 Mar 2019

New insights into peripartum cardiomyopathy in women

In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P. Velarde) pp. 403-408(6); DOI: ttps://doi.org/10.15212/CVIA.2017.0066 Dmitry Yaranov, MD and Jeffrey D. Alexis, MD from the College of Medicine, University of Florida, Jacksonville, FL, USA and the University of Rochester, Rochester, NY, USA consider peripartum cardiomyopathy.

2 Mar 2019

Kinase News and Research

Study offers novel insights into how a major tumor suppressor pathway becomes deactivated

Scientists use a promiscuous inhibitor to uncover cancer drug targets

FDA extends indication of metastatic breast cancer treatment to include male patients

New computational model of human kinase may provide insights for cancer drug development

Mutation in Huntington’s disease may alter interactions of Huntingtin protein with Rac1

Study reveals vitamin B12 as inhibitor of key enzyme in hereditary Parkinson's disease

Tobacco use causes precancerous cells to 'fertilize' nearby cells with cancerous changes

Research reveals genomic basis of acute erythroid leukemia

New targetable vulnerability in breast cancer cells discovered

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

Understanding maintenance of quiescent stem cells in chronic myelogenous leukemia

City of Hope receives $7.5 million in grant awards to study cutaneous T cell lymphoma

Antibody-drug conjugate effectively targets surface protein in childhood neuroblastomas

Researchers develop new molecule that halts progression of heart failure

Parkinson's disease: Servier and Oncodesign announce research and drug development partnership

New clinical genomic testing helps identify mutations that drive childhood melanoma

New insights into peripartum cardiomyopathy in women

Novel mechanism behind DNA damage control uncovered

Miniature tumor organoids could help guide treatment decisions for people with rare cancers

New research finds how cancer cells acquire resistance to molecular-targeted drugs

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News