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GenSight Biologics announces closing of €32 million Series A financing

GenSight Biologics, a biopharmaceutical company focused on the development of ophthalmic therapeutics using gene therapy, announced today the closing of a €32 million Series A financing.

8 Apr 2013

Researchers study influence of muscle types, body metabolism in diabetes

Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabetes is harmful.

8 Apr 2013

Vitamin D improves muscle function, boosts energy levels

Vitamin D is vital for making our muscles work efficiently and boosting energy levels, new research from Newcastle University has shown.

7 Apr 2013

Researchers identify new gene that provides new insight on Perrault syndrome

Researchers from Manchester Biomedical Research Centre at Saint Mary's Hospital and the University of Manchester have identified a new gene, which increases our understanding of the rare inherited disorder Perrault syndrome.

From The University of Manchester 30 Mar 2013

Brown fat cells protective against obesity and diabetes

Brown fat is a hot topic, pardon the pun. Brown fats cells, as opposed to white fat cells, make heat for the body, and are thought to have evolved to help mammals cope with the cold. But, their role in generating warmth might also be applied to coping with obesity and diabetes.

15 Mar 2013

Phase 1b study of olesoxime initiated in multiple sclerosis (MS) patients

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14 Mar 2013

VCP gene mutations cause neurological conditions including IBMPFD and ALS

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).

14 Mar 2013

Combining mitochondrial inhibitors could improve efficacy of BRAF inhibitors in melanoma

A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism.

11 Mar 2013

Drugs that inhibit buildup of acylcarnitines may block axonal degeneration

Anyone whose hand or foot has "fallen asleep" has an idea of the numbness and tingling often experienced by people with peripheral nerve damage. The condition also can cause a range of other symptoms, including unrelenting pain, stinging, burning, itching and sensitivity to touch.

6 Mar 2013

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

2 Mar 2013

Pivotal study of olesoxime in Spinal Muscular Atrophy receives positive interim review

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for under-served medical needs in neurology and cardiology, announced the completion of the interim analysis of the pivotal efficacy study of olesoxime in the rare neurodegenerative condition Spinal Muscular Atrophy (SMA).

1 Mar 2013

UMDNJ biochemist to research into mechanisms that control gene expression in mitochondria

Dmitry Temiakov, PhD, a biochemist at the University of Medicine and Dentistry of New Jersey-School of Osteopathic Medicine, has received a five-year, $1.5 million grant from the National Institutes of Health (NIH) to fund research into the molecular mechanisms that control gene expression in mitochondria, the organelles that are the "power plants" of cellular activity.

1 Mar 2013

Two renowned SCCP scientists earn national recognition from Society of Toxicology

Two renowned scientists at the South Carolina College of Pharmacy (SCCP) have garnered national recognition from the Society of Toxicology (SoT), which named them recipients of two of its individual annual awards. It is the first time these awards have gone to individuals from the same College.

27 Feb 2013

CINJ researcher receives PCF grant for study on lung cancer detection and prevention

Sharon Pine, PhD, a researcher at The Cancer Institute of New Jersey and assistant professor of medicine at the University of Medicine of Dentistry of New Jersey-Robert Wood Johnson Medical School has been awarded a two-year, $80,000 dollar research grant from the Prevent Cancer Foundation.

20 Feb 2013

Two studies discover new enzyme that acts as a sensor of innate immunity

Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections.

16 Feb 2013

Researchers identify mechanism through which mitochondria control breast tumor aggressiveness

Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening mode-an issue with profound implications for treatment. Now a group from The Scripps Research Institute (TSRI) has identified a mechanism through which mitochondria, the powerhouses of a cell, control tumor aggressiveness.

16 Feb 2013

University of Granada’s melatonin gel effective against mucositis

Mucositis is one of the most frequent side effects of chemotherapy and radiotherapy in cancer patients and currently cannot be treated. Investigators at the University of Granada have patented a melatonin gel that is 100% effective against this inflammatory reaction.

15 Feb 2013

Combining synthetic and natural toxins could disarm cancer, drug-resistant bacteria

Cancer researchers from Rice University suggest that a new man-made drug that's already proven effective at killing cancer and drug-resistant bacteria could best deliver its knockout blow when used in combination with drugs made from naturally occurring toxins.

13 Feb 2013

Inhibiting JNK enzyme protects against ischemic/reperfusion injury

Using two different compounds they developed, scientists from the Florida campus of The Scripps Research Institute (TSRI) have been able to show in animal models that inhibiting a specific enzyme protects heart cells and surrounding tissue against serious damage from heart attacks.

10 Feb 2013

Previously poorly investigated signalling pathway crucial for proliferation of prostate cancer cells

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP.

5 Feb 2013