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Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

University of California researchers have found that a newly discovered protein switch which they named neuropeptide S appears to work in the brain to enhance wakefulness and reduce anxiety in laboratory animals. According to Rainer Reinscheid and his colleagues, the protein could help in the understanding of sleep disorders, anxiety, and depression.

18 Aug 2004

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Patients who have had a recent heart attack with ST-elevation (ST-Elevation Myocardial Infarction, or STEMI), complicated by heart failure should be treated with aldosterone blockers according to new guidelines issued recently by the American College of Cardiology (ACC) and the American Heart Association (AHA).

17 Aug 2004

Drug developers should take a different approach to snake venom and heart medications

With the help of snake venom and sophisticated laboratory testing, scientists believe they've uncovered the reason why a group of new heart medications were doing some patients more harm than good.

17 Aug 2004

Relationship between brain chemical messenger glutamate and schizophrenia traits

Researchers at the NIH's National Institute of Mental Health (NIMH) have identified a relationship between a small section of one gene, the brain chemical messenger glutamate, and a collection of traits known to be associated with schizophrenia.

15 Aug 2004

Receptor for estrogen in ovarian cells has been shown to suppress tumor growth

An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research.

15 Aug 2004

Gene responsible for management of glutamate is a promising candidate in determining risk for schizophrenia

Researchers at the National Institute of Mental Health have identified a relationship between a small section of one gene, the brain chemical messenger glutamate, and a collection of traits known to be associated with schizophrenia.

11 Aug 2004

New biotech alliance to focus on diseases of nerve injury and pain

NeuroTargets Ltd, a discovery-led biotechnology company ‘spun-out’ from the University of Bristol, has formed an exciting new alliance with BioFocus plc, a world leader in collaborative drug discovery, to focus on diseases of nerve injury and pain.

11 Aug 2004

Scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning

Using a new molecular genetic technique, scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning. Without the gene, the monkeys lost their sense of balance between reward and the work required to get it, say researchers at the National Institute of Mental Health .

11 Aug 2004

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

Some patients with hypertension or other cardiovascular diseases should be closely monitored in order to maintain safe potassium levels in the body when prescribed certain medications, counsels a nephrologist at UT Southwestern Medical Center at Dallas.

11 Aug 2004

New direction for research into Sly Syndrome

Findings by a Saint Louis University research team led by the scientist who discovered Sly Syndrome 32 years ago point to a new direction for research into the rare genetic disorder that can cause bone deformities, vision and hearing loss, mental retardation and death in children.

9 Aug 2004

Carb-conscious dieters may be lowering their risk of breast cancer

Carb-conscious dieters may be lowering their risk of breast cancer while they’re shedding pounds, based on the findings of research published in this month’s edition of the journal Cancer Epidemiology, Biomarkers & Prevention.

9 Aug 2004

Many U.S. surgeons are not doing adequate numbers of operations for primary breast cancer to optimize patient survival

The study, published August 9, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, demonstrates that fewer surgeries per year negatively impacted patient standard of care. A free abstract of the study is available at CANCER Online.

9 Aug 2004

Self-recovery from Hep C infection linked to genes that suppress action of killer immune cells

In a study to be published in Science online Aug. 6, researchers at Johns Hopkins have found that genes involved in suppressing the body's defensive "killer" immune cells are a potential key factor in spontaneous recovery from hepatitis C.

5 Aug 2004

New twist to the 2001 anthrax attacks in the U.S.

In a new twist to the 2001 anthrax attacks in the U.S., the Federal Bureau of Investigation is searching 2 homes in new York and New Jersey which may be related to the attacks.

5 Aug 2004

Physicians offer several promising and unique approaches to brain tumor treatment

An estimated 41,000 new cases of primary brain tumors are expected to be diagnosed in 2004, according to the American Brain Tumor Association.

5 Aug 2004

Smart drug that targets cancer cells in the brain following removal of a tumor

The use of a "smart" drug that targets cancer cells in the brain following removal of a tumor may provide treatment that can extend the survival of people with the most common form of primary malignant brain tumor, glioblastoma multiforme (GBM).

3 Aug 2004

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

Overwhelming evidence accumulated during almost 20 years of clinical experience has established the benefits of this drug, which blocks the harmful effects of angiotensin, a substance that causes blood vessels to narrow, said the study authors.

3 Aug 2004

FDA has granted orphan drug designation to Myogen's ambrisentan, for the treatment of pulmonary arterial hypertension

Myogen has announced that the United States Food and Drug Administration has granted orphan drug designation to ambrisentan for the treatment of pulmonary arterial hypertension (PAH).

3 Aug 2004

New glycan arrays discover autoimmunogenic activities of SARS-CoV

Researchers in New York City and Guangzhou, China applied the rapidly-developing carbohydrate microarray technology to study an inactivated SARS-coronavirus (SARS-CoV) vaccine and discovered autoimmunogenic activity of this newly identified human viral pathogen.

2 Aug 2004

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

ATP - adenosine triphosphate, the vital energy source that keeps our body’s cells alive, runs amok at the site of a spinal cord injury, pouring into the area around the wound and killing the cells that normally allow us to move, scientists report in the cover story of the August issue of Nature Medicine.

29 Jul 2004

Receptor News and Research

Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Drug developers should take a different approach to snake venom and heart medications

Relationship between brain chemical messenger glutamate and schizophrenia traits

Receptor for estrogen in ovarian cells has been shown to suppress tumor growth

Gene responsible for management of glutamate is a promising candidate in determining risk for schizophrenia

New biotech alliance to focus on diseases of nerve injury and pain

Scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

New direction for research into Sly Syndrome

Carb-conscious dieters may be lowering their risk of breast cancer

Many U.S. surgeons are not doing adequate numbers of operations for primary breast cancer to optimize patient survival

Self-recovery from Hep C infection linked to genes that suppress action of killer immune cells

New twist to the 2001 anthrax attacks in the U.S.

Physicians offer several promising and unique approaches to brain tumor treatment

Smart drug that targets cancer cells in the brain following removal of a tumor

Third of heart failure patients face increased risk of death because they do not receive an angiotensin-converting enzyme (ACE) inhibitor

FDA has granted orphan drug designation to Myogen's ambrisentan, for the treatment of pulmonary arterial hypertension

New glycan arrays discover autoimmunogenic activities of SARS-CoV

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

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Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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