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Molecular underpinning of chronic bone infection in patients with mycobacterial disease revealed

About a quarter of the world's population is infected with tuberculosis bacteria, according to the World Health Organization, but only about 5 to 10% of those infected will develop symptoms. These pathogens are mycobacteria, which are everywhere, including in chlorine-treated tap water.

8 Sep 2021

Scientists model the process of capsid disassembly in hepatitis B virus at atomic level

With up to 2.4 million U.S. cases and over 250 million chronic cases globally, hepatitis B infection persists despite the availability of a vaccine.

8 Sep 2021

Sepsis mortality risk linked to the degree of platelet reduction

Researchers have revealed that the degree of platelet reduction, rather than absolute platelet count, is linked to mortality risk in sepsis.

8 Sep 2021

Interorgan network plays an essential role in maternal antibody transfer through breastfeeding

Breastfeeding offers an array of benefits for mothers and newborns. Maternal antibodies are transferred via breastfeeding, protecting the gastrointestinal tracts of babies from several pathogen-caused infections.

8 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

A new study successfully identifies a series of inhibitors that possesses pancoronavirus activity against SARS-CoV, SARS-CoV-2, and MERS-CoV.

7 Sep 2021

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

An intriguing new study reports a year-long study in patients with cMCADs from all over France.

7 Sep 2021

Study pinpoints an entirely new approach for treatment of biliary atresia

Biliary atresia is the largest cause of end-stage liver fibrosis in children and the main reason children need liver transplants. Despite many years of worldwide research, scientists have not yet found a way to prevent the condition.

7 Sep 2021

Researchers find potential new target for treating systemic inflammation in obesity

A study led by researchers at the University of Chicago and Indiana University has determined that a protein called elF5A is necessary for driving inflammation in macrophage cells in obesity.

7 Sep 2021

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.

7 Sep 2021

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female.

7 Sep 2021

Cancer immunotherapies could benefit older patients as much as younger people

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Study offers important evidence for the safety of stem cell transplants

Stem cell transplants do not lead to changes in the DNA of the donor cells. That's according to a new study, which provides important evidence for the safety of this procedure.

7 Sep 2021

Research uses rodent models to connect the influence of feronomic signals on memory

The work, published recently in Nature Communications, used a model of rodents and managed to connect for the first time the influence of feronomic signals on memory. This will make it possible to explore the deficits of integration of spatial memories and social studies in transgenic models of Alzheimer's disease in the future.

7 Sep 2021

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

A team of scientists in Ireland recently identified certain immune markers that can predict the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to severe coronavirus disease 2019 (COVID-19). Early detection of these predictive markers can facilitate therapeutic decision-making prior to peak severity.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Scientists from the National Institutes of Health, USA, have recently demonstrated the immunogenicity and protective efficacy of two vesicular stomatitis virus (VSV)-based coronavirus disease 2019 (COVID-19) vaccines in hamsters.

6 Sep 2021

Implications of persistent SARS-CoV-2 infection in patients with lymphoid malignancies

In a recent study, scientists attempt to understand persistent COVID-19 and its implications in patients with hematologic malignancies.

6 Sep 2021

Maternal SARS-CoV-2 vaccination in early-third trimester may optimize neonatal seroprotection

Researchers in Israel have conducted a study showing that vaccinating pregnant women against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early on in the third trimester may maximize transplacental antibody transfer, potentially helping to prevent severe coronavirus disease 2019 (COVID-19) during infancy.

6 Sep 2021

Study sheds light on neurologic symptoms caused by SARS-CoV-2 infection

Researchers in Australia and Finland have provided important insights into how infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – might affect nervous system circuitries and cause neurologic symptoms.

6 Sep 2021

B Cell News and Research

Molecular underpinning of chronic bone infection in patients with mycobacterial disease revealed

Scientists model the process of capsid disassembly in hepatitis B virus at atomic level

Sepsis mortality risk linked to the degree of platelet reduction

Interorgan network plays an essential role in maternal antibody transfer through breastfeeding

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

Study pinpoints an entirely new approach for treatment of biliary atresia

Researchers find potential new target for treating systemic inflammation in obesity

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

Cancer immunotherapies could benefit older patients as much as younger people

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Study offers important evidence for the safety of stem cell transplants

Research uses rodent models to connect the influence of feronomic signals on memory

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Vesicular stomatitis virus-based COVID vaccines demonstrate potent antiviral efficacy against SARS-CoV-2 variants

Implications of persistent SARS-CoV-2 infection in patients with lymphoid malignancies

Maternal SARS-CoV-2 vaccination in early-third trimester may optimize neonatal seroprotection

Study sheds light on neurologic symptoms caused by SARS-CoV-2 infection

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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