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Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard.

25 Sep 2019

Nanotechnology enhances delivery of chemotherapy drugs

Michigan State University scientists have invented a new way to monitor chemotherapy concentrations, which is more effective in keeping patients' treatments within the crucial therapeutic window.

25 Sep 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019

Study shows health, work benefits of Medicaid expansion for adults with behavioral health disorders

Expanding Medicaid to more low-income adults helped many of them feel healthier, and do a better job at work or a job search, in just one year after they got their new health coverage, a University of Michigan study finds.

25 Sep 2019

Metformin for diabetics with renal damage scores over Sulphonylureas in terms of heart safety

There are several drugs that are being used for treatment of type 2 diabetes. Many type 2 diabetics suffer from kidney disorders that are caused by persistent high levels of blood sugar.

25 Sep 2019

New compound could take on lethal fungal, bacterial infections in immunocompromised people

Immunodeficiency is the condition where the capability of the immune system to fight against diseases has been compromised.

25 Sep 2019

UCLA researchers identify new drug delivery pathway to stop tumor growth

Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice.

25 Sep 2019

Johns Hopkins researchers link a gene to melanoma growth and spread

Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3.

From Johns Hopkins Medicine 25 Sep 2019

Molecular changes are linked with adverse events following treatment of lymphatic filariasis

The Global Program to Eliminate Lymphatic Filariasis delivers mass drug administration to 500 million people each year, and adverse events are common following treatment. Now, researchers have reported in PLOS Neglected Tropical Diseases that certain changes in gene expression are associated with these adverse events.

From PLOS ONE 25 Sep 2019

Study: Infectious disease specialists can reduce mortality rate in hospitalized patients

Bloodstream infections caused by the fungus Candida are among the most common and deadly infections in hospitals, with 25,000 such cases seen annually in the U.S. – mostly in people originally hospitalized for other reasons. About 40% to 45% of people with Candida in their blood die of the infection.

25 Sep 2019

Study shows metformin is safe for patients with mild-to- moderate kidney disease

Over the years, there has been uncertainty over which drugs are best for patients with Type 2 diabetes and one of its common complications, kidney disease.

25 Sep 2019

The ear's sensitivity to sound is controlled by outer hair cells

The human inner ear has a type of cell called the outer hair cell. These were thought to amplify sounds from the environment. However, a new study based on hearing in gerbils shows these cells are probably involved in regulating the sensitivity of the ear to sound. This could help find ways to preserve good hearing by protecting these cells from destruction.

25 Sep 2019

Love hormone oxytocin linked to hypersexuality

Sex addiction or hypersexual disorder is a behavior characterized by an excessive preoccupation with sexual fantasies, behaviors, or urges that are hard to control, causing negative effects on one’s health and relationships.

25 Sep 2019

At raucous hearing, no unity on vaping issues

Opposing views on e-cigarettes, witnesses interrupting members of Congress and even a wink. A hearing Tuesday on the epidemic of respiratory injuries linked to vaping was one unusual show.

24 Sep 2019

TUM researchers reveal how chaperones detect immature immune signaling proteins

The cells of our immune system constantly communicate with one another by exchanging complex protein molecules.

24 Sep 2019

Migraine knowledge poor among university students

Migraine is a particularly agonizing condition, much more than a simple headache, affecting 5% to 12% of the population. However, the condition is not diagnosed in many patients, forcing them to undergo severe pain for years on end. One of the causes for this widespread under-diagnosis is the lack of knowledge of the features that distinguish a migraine from a non-migraine headache.

24 Sep 2019

Green tea compound shows promise in tackling antibiotic resistance

Green tea has gained immense popularity across the globe, mainly because of its health benefits. Green tea extract has been used for many purposes – for weight loss, improved brain function, enhanced metabolism, and lower risk of some types of cancer, among others.

24 Sep 2019

Oncologists respond quickly to emerging FDA safety data for drugs, study finds

Within six months of the U.S. Food and Drug Administration's move to restrict the label of two immunotherapies, usage of those therapies among oncologists dropped by about 50 percent, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania.

24 Sep 2019

Electronic conversations between neurons could soon be recorded precisely

Electrodes are used to pick up electrical signals. Neurons however are tiny units of the nervous system and it is difficult to create an electrode small enough to record all the workings of a neurons.

24 Sep 2019

Wistar awarded more than $12 million to study opioid use in HIV-infected people

The Wistar Institute was awarded two major grants totaling more than $12 million from the National Institute on Drug Abuse, part of the National Institutes of Health, to fund an international multidisciplinary clinical research consortium spearheaded by Wistar's HIV Research Program.

24 Sep 2019