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Powerful new tools can study glycans’ function

Scientists at The Scripps Research Institute have developed chemical compounds that can make key modifications to common sugar molecules ("glycans"), which are found on the surface of all cells in our body. The new study presents powerful new tools for studying these molecules' function, for example in cell signaling and immunity, and for investigating new treatments for chronic inflammation, autoimmune diseases, cancer metastasis, and related conditions.

11 Jun 2012

First Edition: June 11, 2012

Today's headlines feature reports that UnitedHealthcare plans to honor some health law provisions regardless of what the Supreme Court decides.

11 Jun 2012

POI signs multi-year contract for DATATRAK ONE products

DATATRAK International, Inc., a technology and services company focused on global eClinical solutions for the clinical trials industry, today announced Pharm-Olam International (POI), a global Contract Research Organization (CRO), signed a multi-year, multi-million dollar contract standardizing on the cloud-based unified clinical research platform, DATATRAK ONE.

11 Jun 2012

Acacia subsidiary announces acquisition of 7 medtech patent portfolios

Acacia Research Corporation announced today that a subsidiary has acquired 7 medtech patent portfolios comprised of over 150 patents and pending applications relating to medical devices, biologics and diagnostic techniques.

11 Jun 2012

Short sleep periods increase risk of stroke in normal-weight adults

Habitually sleeping less than six hours a night significantly increases the risk of stroke symptoms among middle-age to older adults who are of normal weight and at low risk for obstructive sleep apnea (OSA), according to a study of 5,666 people followed for up to three years.

11 Jun 2012

Data from first feasibility study of artificial pancreas system

Results from the first feasibility study of an advanced first-generation artificial pancreas system were presented today at the 72nd Annual American Diabetes Association Meeting in Philadelphia. Findings from the study indicated that the Hypoglycemia-Hyperglycemia Minimizer (HHM) System was able to automatically predict a rise and fall in blood glucose and correspondingly increase and/or decrease insulin delivery safely.

11 Jun 2012

Nanocontainers can fight against atherosclerosis

In Switzerland, more than 20,000 people (37% of all deaths) die of cardiovascular disease caused by atherosclerosis each year. Treatment options are currently available to people who suffer from the disease but no drug can target solely the diseased areas, often leading to generalized side effects.

11 Jun 2012

MRI scans reveal how sleep deprivation impairs brain regions associated with food processing

MRI scans from a study being presented today at SLEEP 2012 reveal how sleep deprivation impairs the higher-order regions in the human brain where food choices are made, possibly helping explain the link between sleep loss and obesity that previous research has uncovered.

11 Jun 2012

Zafgen announces new data from two Phase 1 studies of beloranib on obesity

Zafgen, Inc., the world's first biopharmaceutical company dedicated to addressing the unmet need of severely obese patients, today announced new data from two Phase 1 studies of beloranib, a selective methionine aminopeptidase 2 inhibitor (MetAP2), which showed significant weight loss and improvements in cardiometabolic risk markers in severely obese women.

11 Jun 2012

Researchers identify new mitochondrial protein complex linked with type 2 diabetes

Researchers at Metabolic Solutions Development Company, LLC (MSDC) have identified a mitochondrial protein complex through which anti-diabetic drugs exert their insulin sensitizing effects when used to treat patients diagnosed with type 2 diabetes.

11 Jun 2012

New understanding about how placental growth is regulated before birth

Scientists at the Babraham Institute have gained a new understanding of how the growth of the placenta is regulated before birth, which has important implications for a healthy pregnancy.

11 Jun 2012

Pre-operative aspirin therapy may reduce risk of acute kidney failure after CABG surgery

Aspirin taken for five days before a heart operation can halve the numbers of patients developing post-operative acute kidney failure, according to research presented at the European Anaesthesiology Congress in Paris.

11 Jun 2012

Study uses brain scans to better understand link between sleep restriction and obesity

The sight of unhealthy food during a period of sleep restriction activated reward centers in the brain that were less active when participants had adequate sleep, according to a new study using brain scans to better understand the link between sleep restriction and obesity.

11 Jun 2012

Glucose-lowering regulations in people with prediabetes achieves reduction in progression to diabetes in the long term

People with “prediabetes” (a high risk state for overt type 2 diabetes) who experience a period of normal glucose regulation are 56% less likely to develop diabetes 5∙7 years later, according to a new research Article presented at the American Diabetes Association 72nd Scientific Sessions on Saturday 9 June, and published Online First in The Lancet. This is one of four Articles (all presented at the American Diabetes Association 72nd Scientific Sessions) and a Series of three papers that are part of a special Lancet theme issue on diabetes [1].

11 Jun 2012

Amylin announces results from SYMLIN clinical studies on type 2 or 1 diabetes

Amylin Pharmaceuticals, Inc. today announced results from new analyses of previously completed clinical studies demonstrating that patients with type 2 or type 1 diabetes achieved a greater proportion of blood glucose measurements in the normal range when SYMLIN (pramlintide acetate) injection treatment was used along with insulin.

11 Jun 2012

Sleep loss markedly exaggerates emotional reactivity in people with anxiety disorders

New research shows that sleep loss markedly exaggerates the degree to which we anticipate impending emotional events, particularly among highly anxious people, who are especially vulnerable.

11 Jun 2012

Amylin, Alkermes announce results from BYDUREON clinical study on type 2 diabetes

Amylin Pharmaceuticals, Inc. and Alkermes plc today announced results from the long-term extension of the DURATION-1 study, which showed that BYDUREON (exenatide extended-release for injectable suspension), the first and only once-weekly treatment for type 2 diabetes, was associated with clinically significant and sustained improvements in glycemic control during four years of treatment in adults with type 2 diabetes.

11 Jun 2012

First study to use simulated driving tests on medical staff returning home after night shift

The drowsiness experienced by medical staff who have been on night duty can make their driving dangerous, French researchers have found.

11 Jun 2012

Florida Hospital, Profil Institute to establish new center for metabolic disease research

Profil Institute for Clinical Research, Inc., a company focused on early phase clinical trials for diabetes and obesity, and Florida Hospital, one of nation's largest clinical care providers, announced today a joint venture to establish a state-of-the-art early phase clinical services center for metabolic disease research, including diabetes, obesity and cardiometabolic diseases.

11 Jun 2012

Majority of African-American patients with hypertension suffer from hidden heart disease

A Wayne State University School of Medicine study has found that an overwhelming majority of African-American patients with hypertension also suffered hidden heart disease caused by high blood pressure even though they displayed no symptoms.

11 Jun 2012

Research News and Research

Powerful new tools can study glycans’ function

First Edition: June 11, 2012

POI signs multi-year contract for DATATRAK ONE products

Acacia subsidiary announces acquisition of 7 medtech patent portfolios

Short sleep periods increase risk of stroke in normal-weight adults

Data from first feasibility study of artificial pancreas system

Nanocontainers can fight against atherosclerosis

MRI scans reveal how sleep deprivation impairs brain regions associated with food processing

Zafgen announces new data from two Phase 1 studies of beloranib on obesity

Researchers identify new mitochondrial protein complex linked with type 2 diabetes

New understanding about how placental growth is regulated before birth

Pre-operative aspirin therapy may reduce risk of acute kidney failure after CABG surgery

Study uses brain scans to better understand link between sleep restriction and obesity

Glucose-lowering regulations in people with prediabetes achieves reduction in progression to diabetes in the long term

Amylin announces results from SYMLIN clinical studies on type 2 or 1 diabetes

Sleep loss markedly exaggerates emotional reactivity in people with anxiety disorders

Amylin, Alkermes announce results from BYDUREON clinical study on type 2 diabetes

First study to use simulated driving tests on medical staff returning home after night shift

Florida Hospital, Profil Institute to establish new center for metabolic disease research

Majority of African-American patients with hypertension suffer from hidden heart disease

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