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Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

Immune reactions caused by vaccination can help protect the organism, or sometimes may aggravate the condition.

15 Sep 2020

3D printed nanoparticle biosensing platform detects SARS-CoV-2 antibodies within seconds

Pandemics caused by novel infectious agents like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika, or Ebola virus seriously impact human health and lives while also overwhelming health care systems all over the world. Early detection and diagnosis allow isolation of the infected patients and contact tracing, which can mitigate the spread of the virus and save lives, especially when a significant number of the patients are asymptomatic.

14 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

HSC researchers win NIH grant to expand innovative research into Alzheimer's disease

Researchers at HSC Fort Worth were awarded a grant expected to total $45 million from the National Institute on Aging, part of the National Institutes of Health, to expand innovative research into Alzheimer's disease and the biological differences that cause the disease to disproportionately afflict Mexican Americans.

14 Sep 2020

RUDN geneticist finds a bifidobacterial protein that can reduce inflammation in COVID-19

A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the inflammatory process and discovered that their surface protein is capable of stopping excessive or uncontrollable inflammation, like the one observed in COVID-19 patients.

14 Sep 2020

Oxford University and AstraZeneca resume COVID-19 vaccine trial

More than a hundred candidate vaccine trials against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19), are underway. About 35 are now undergoing clinical evaluation, and of these, nine are in the final phase of human trials, including the vaccine developed by Oxford University and the biopharmaceutical firm, AstraZeneca.

14 Sep 2020

Tiny antibody component shows high potency in SARS-CoV-2 animal models

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.

14 Sep 2020

Computational models screen for coronaviruses likely to infect humans

The researchers from Rochester Institute of Technology and the Hauptmann-Woodward Medical Research Institute produced models of the receptor-binding domain (RBD) found on outbreak strains of betacoronaviruses and its interaction with the host cell receptor angiotensin-converting enzyme 2 (ACE2).

14 Sep 2020

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers at the Babraham Institute have used their understanding of cellular signalling to highlight a pitfall in an emerging treatment for cancer and inflammation.

14 Sep 2020

Single-molecule imaging of SARS-CoV-2 spikes on virus particles

Using single-molecule FRET analysis, a team of researchers has revealed how the different conformations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are interconnected. Figuring out the different conformations in real-time and which conformations antibodies prefer may help design effective vaccines and drugs. The research is published on the preprint server bioRxiv*.

14 Sep 2020

Researchers identify the missing link in the production of nitric oxide

Some microorganisms, the so-called methanotrophs, make a living by oxidizing methane (CH4) to carbon dioxide (CO2). Ammonia (NH3) is structurally very similar to methane, thus methanotrophs also co-metabolize ammonia and produce nitrite.

14 Sep 2020

New insights into structural stability of SARS-CoV-2 main protease

In a recent bioRxiv preprint paper, researchers from the US and Italy utilized molecular dynamics simulations and revealed that the conformational stability of the SARS-CoV-2 binding site, bound inhibitors, and the hydrogen bond networks of the viral main protease (Mpro) are highly sensitive to protonation assignments.

13 Sep 2020

New research reverses the understanding of kidney tumor growth

Newly published research has reversed our understanding of an aspect of kidney tumor growth. Researchers at Huntsman Cancer Institute at the University of Utah (U of U) discovered that two key proteins have opposite roles than what was previously believed.

12 Sep 2020

UMSOM researchers determine role of protein in development of hearing hair cells

Researchers at the University of Maryland School of Medicine have conducted a study that has determined the role that a critical protein plays in the development of hair cells.

12 Sep 2020

Yale researchers identify possible treatment for Duchenne muscular dystrophy

Researchers at Yale have identified a possible treatment for Duchenne muscular dystrophy (DMD), a rare genetic disease for which there is currently no cure or treatment, by targeting an enzyme that had been considered "undruggable."

12 Sep 2020

Improving lifestyle of pregnant women with obesity could lead to healthier children

New research shows improving the lifestyle of women with obesity during pregnancy could mean long-term cardiovascular benefits for their children.

12 Sep 2020

Researchers develop highly scalable, accurate antibody test for COVID-19

An antibody test for the virus that causes COVID-19, developed by researchers at The University of Texas at Austin in collaboration with Houston Methodist and other institutions, is more accurate and can handle a much larger number of donor samples at lower overall cost than standard antibody tests currently in use.

12 Sep 2020

Scientists elucidate cause for Parkinson's disease and identify potential treatments

In a seven-year research effort, an international team of scientists has clarified the cause for certain genetic forms of Parkinson's disease, and has identified potential pharmacological treatments.

12 Sep 2020

Antiviral effects of honeysuckle decoction affected in SIDT1poly population

Previously, Chen-Yu Zhang's group have identified SID1 transmembrane family member 1 (SIDT1) as a critical membrane protein mediating dietary miRNAs absorption, which is abolished in SIDT1 deficient mice.

11 Sep 2020

Seroconversion marks recovery from COVID-19

Nine months into the COVID-19 pandemic, scientists are still seeking to understand the protective immunity that develops against the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the increasing need for serological tests in epidemiology, their clinical value has not been fully established. A new paper published in the Journal of Medical Virology in September 2020 describes the relationship of COVID-19 disease symptoms with the serological status over time.

11 Sep 2020

Protein C News and Research

Immunologists analyze types of immune response to predict an effective COVID-19 vaccine

3D printed nanoparticle biosensing platform detects SARS-CoV-2 antibodies within seconds

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

HSC researchers win NIH grant to expand innovative research into Alzheimer's disease

RUDN geneticist finds a bifidobacterial protein that can reduce inflammation in COVID-19

Oxford University and AstraZeneca resume COVID-19 vaccine trial

Tiny antibody component shows high potency in SARS-CoV-2 animal models

Computational models screen for coronaviruses likely to infect humans

Cell signaling research rings warning bells over an emerging cancer drug target

Single-molecule imaging of SARS-CoV-2 spikes on virus particles

Researchers identify the missing link in the production of nitric oxide

New insights into structural stability of SARS-CoV-2 main protease

New research reverses the understanding of kidney tumor growth

UMSOM researchers determine role of protein in development of hearing hair cells

Yale researchers identify possible treatment for Duchenne muscular dystrophy

Improving lifestyle of pregnant women with obesity could lead to healthier children

Researchers develop highly scalable, accurate antibody test for COVID-19

Scientists elucidate cause for Parkinson's disease and identify potential treatments

Antiviral effects of honeysuckle decoction affected in SIDT1poly population

Seroconversion marks recovery from COVID-19

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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