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Using 3D patient tumor avatars to guide cancer treatment decisions

At any time, most cancer patients are receiving a treatment that does not significantly benefit them while enduring bodily and financial toxicity.

20 Dec 2022

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Previous traumatic brain injury may potentially affect frontotemporal dementia risk

A recent study from the University of Eastern Finland shows that previous traumatic brain injury may potentially affect the risk of frontotemporal dementia.

19 Dec 2022

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

Researchers evaluated the immunogenicity and safety of the COVID-19 bivalent mRNA vaccine mRNA-1273.222 and tested the neutralizing ability of the two bivalent vaccines — mRNA-1273.222 and mRNA-1273.214 — against the newly emergent Omicron subvariants.

19 Dec 2022

An assessment of T cell and antibody immunity against SARS-CoV-2 VOCs and the effect of booster shots

A new study in the journal Vaccines aimed to analyze the long-term kinetics of SARS-CoV-2 specific T cell and humoral responses following primary and booster vaccinations in previously infected individuals.

18 Dec 2022

Origins of the serious cancer-like disease LCH discovered

The origins of the serious cancer-like disease LCH have been identified by researchers from Karolinska Institutet in collaboration with Karolinska University Hospital. The findings presented in Science Immunology may lead to new, targeted treatments.

16 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Researchers demonstrated the exceptional immune evasion properties of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, BQ and XBB.

16 Dec 2022

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

A new study published on Dec. 14, 2022 in the New England Journal of Medicine reports the identification of a previously unknown genetic cause of a late-onset cerebellar ataxia, a discovery that will improve diagnosis and open new treatment avenues for this progressive condition.

15 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Research maps the evolution and natural selection of E. coli bacteria

Antibiotic resistance, when infection-causing bacteria evolve so they are no longer affected by typical antibiotics, is a global concern.

14 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

Researchers from The University of Texas MD Anderson Cancer Center are presenting compelling findings from three clinical trials at the 2022 American Society of Hematology Annual Meeting.

13 Dec 2022

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Huntington's disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function.

12 Dec 2022

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

New computer model can help researchers to spot which cells acquire alterations during development

Scientists at Johns Hopkins Medicine say they have developed a computer model - dubbed quantitative fate mapping - that looks back in the developmental timeline to trace the origin of cells in a fully grown organism

12 Dec 2022

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Researchers compare the contribution of antibodies against the SARS-CoV-2 receptor binding domain in vaccinated and naturally infected adults and children.

12 Dec 2022

XBB Omicron variant evades vaccine-induced immunity

A new study published in The Lancet Microbe examines the immune evasion characteristics of the Omicron XBB subvariant.

12 Dec 2022

Many genetic disorders respond well to specialized gene therapy

When the normal DNA sequence in an individual changes or mutates it can cause disease. The mutation may involve multiple genes and may be caused by environmental factors, or there may be chromosomal defects that are harmful at birth, in infancy or environment at a later stage.

12 Dec 2022

Signaling pathway within brain cells regulates sleep

A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?

12 Dec 2022

Mutation News and Research

Using 3D patient tumor avatars to guide cancer treatment decisions

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Previous traumatic brain injury may potentially affect frontotemporal dementia risk

Safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent booster mRNA-1273.222

An assessment of T cell and antibody immunity against SARS-CoV-2 VOCs and the effect of booster shots

Origins of the serious cancer-like disease LCH discovered

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Study uncovers previously unknown genetic cause of late-onset cerebellar ataxia

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Research maps the evolution and natural selection of E. coli bacteria

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

Targeted therapies and novel drug combinations show promise for the treatment of multiple leukemias

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

New computer model can help researchers to spot which cells acquire alterations during development

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

XBB Omicron variant evades vaccine-induced immunity

Many genetic disorders respond well to specialized gene therapy

Signaling pathway within brain cells regulates sleep

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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