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Study describes design and effectiveness of NIR responsive gold nanorods for chemotherapy

Excitement around the potential for targeted nanoparticles (NPs) that can be controlled by stimulus outside of the body for cancer therapy has been growing over the past few years. More specifically, there has been considerable attention around near-infrared (NIR) light as an ideal method to stimulate nanoparticles from outside the body.

19 Oct 2012

EMA CHMP issues positive opinion to Savient's KRYSTEXXA for treatment of chronic gout

Savient Pharmaceuticals, Inc. and its wholly owned subsidiary, Savient Pharma Ireland Limited, announced that the European Medicines Agency's Committee for Medicinal Products for Human Use has completed its scientific assessment and has issued a positive opinion recommending approval of a marketing authorization in the European Union for KRYSTEXXA for the treatment of severe debilitating chronic tophaceous gout in adult patients who may also have erosive joint involvement and who have failed to normalize serum uric acid with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these medicines are contraindicated.

19 Oct 2012

ACT TIL therapy effective in treating metastatic melanoma

Researchers at Moffitt Cancer Center have carried out a clinical trial in which patients with metastatic melanoma were given chemotherapy and an immunotherapy of adoptive cell transfer (ACT) with tumor infiltrating lymphocytes (TIL).

19 Oct 2012

Link between norovirus outbreaks and excess hospitalization and mortality in nursing homes

In a study that included more than 300 Medicare-certified nursing homes, rates of hospitalization and death were substantially increased during outbreaks of norovirus gastroenteritis vs. non-outbreak periods, according to a study appearing in the October 24/31 issue of JAMA.

19 Oct 2012

Neuralstem initiates second cohort NSI-189 Phase Ib trial in major depressive disorder

Neuralstem, Inc. announced that it has begun dosing the second cohort of patients in its ongoing Phase Ib to test the safety of NSI-189 in the treatment of major depressive disorder (MDD).

19 Oct 2012

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Pfizer Inc. announced today that a Phase 3 study of INLYTA (axitinib) did not meet its primary endpoint of demonstrating statistically significantly longer progression-free survival, versus sorafenib, in treatment-naïve patients with advanced renal cell carcinoma.

18 Oct 2012

Genetic clues for responders to heart failure drug identified

Researchers have identified genetic signatures that predict which patients respond to the beta blocker bucindolol.

18 Oct 2012

Ciclosporin no more effective than infliximab in severe UC

Ciclosporin and infliximab have similar efficacy for the treatment of patients with refractory severe ulcerative colitis, show the findings of a multinational trial.

18 Oct 2012

Value of cranberries for UTI prevention called into question

Results from an updated systematic review suggest that the value of cranberry juice or capsule consumption for prevention of urinary tract infections is likely to be limited.

17 Oct 2012

EMR before radiofrequency ablation safe and effective for patients with nodular Barrett's esophagus

A new study shows that endoscopic mucosal resection (EMR) before radiofrequency ablation (RFA) is a safe and effective treatment option for patients with nodular Barrett's esophagus (BE) and advanced neoplasia.

17 Oct 2012

FDA accepts A.P. Pharma’s resubmission of NDA for APF530

A.P. Pharma, Inc., a specialty pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has accepted the Company's resubmission of its New Drug Application (NDA) for APF530.

17 Oct 2012

BioLineRx completes pre-clinical development of BL-8020 for HCV

BioLineRx, a biopharmaceutical development company, announced today that it has successfully completed the pre-clinical development of BL-8020, an orally available, interferon-free treatment for the Hepatitis C virus (HCV), and plans to commence a Phase I/II safety and efficacy study for BL-8020 in Europe during the first quarter of 2013.

17 Oct 2012

Rehabilitation program combats occupational skin disease

Results from a German study suggest that a 6–10 week rehabilitation program set up to help people overcome severe occupational skin disease continues to have significant benefits for participants 1 year after discharge.

16 Oct 2012

VOICES of children with ADHD support medication use

Children with attention deficit/hyperactivity disorder benefit from the use of stimulant medication and do not feel that it turns them into “robots,” suggests research.

16 Oct 2012

Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

A comprehensive new review on how to treat high cholesterol and other blood lipid problems suggests that intensive treatment with high doses of statin drugs is usually the best approach.

16 Oct 2012

Drug-eluting balloon procedure can effectively treat peripheral artery disease

Use of balloon angioplasty and placement of stents to widen clogged arteries have become standard medical procedure. Further advancing this treatment, drug-eluting devices are now delivering medication directly to the site where it can be most effective. While this technique has met with success in coronary arteries, its use in peripheral arteries is still under study.

16 Oct 2012

NIAID-funded study to evaluate PPSV23 and PCV13 in Phase Iib pneumococcal trial

Researchers plan to see if a higher dose of a pneumococcal vaccine will create a stronger immune response in older adults who received an earlier generation vaccine against pneumonia and other pneumococcal diseases.

16 Oct 2012

Computer-delivered interventions do not effectively curb problematic college drinking

Computer-delivered and face-to-face interventions both can help curb problematic college drinking for a little while, but only in-person encounters produce results that last beyond a few months, according to a new analysis of the techniques schools use to counsel students on alcohol consumption.

16 Oct 2012

Physicians urged to think twice before they prescribe compounded drugs

The recent outbreak of meningitis in the US-and the subsequent deaths of 15 individuals-has renewed scrutiny on the contemporary practice of pharmacy compounding. The risks to patients, and associated liability risk to prescribing physicians, largely outweigh the benefits when the practice goes beyond the traditional, extemporaneous role, according to Sarah Sellers from q-Vigilance LLC and Wulf Utian from Case Western Reserve University in the US. Sellers and Utian's opinion piece appears online in the journal Drugs, published by Adis.

16 Oct 2012

Mother's kiss appears to be safe and effective in dislodging objects from nasal cavity of kids

A technique called the "mother's kiss" for removing foreign objects from the nasal passages of young children appears to be a safe and effective approach, found a study published in CMAJ.

16 Oct 2012

Efficacy News and Research

Study describes design and effectiveness of NIR responsive gold nanorods for chemotherapy

EMA CHMP issues positive opinion to Savient's KRYSTEXXA for treatment of chronic gout

ACT TIL therapy effective in treating metastatic melanoma

Link between norovirus outbreaks and excess hospitalization and mortality in nursing homes

Neuralstem initiates second cohort NSI-189 Phase Ib trial in major depressive disorder

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Genetic clues for responders to heart failure drug identified

Ciclosporin no more effective than infliximab in severe UC

Value of cranberries for UTI prevention called into question

EMR before radiofrequency ablation safe and effective for patients with nodular Barrett's esophagus

FDA accepts A.P. Pharma’s resubmission of NDA for APF530

BioLineRx completes pre-clinical development of BL-8020 for HCV

Rehabilitation program combats occupational skin disease

VOICES of children with ADHD support medication use

Intensive treatment with high doses of statin drugs shows promise for dyslipidemia

Drug-eluting balloon procedure can effectively treat peripheral artery disease

NIAID-funded study to evaluate PPSV23 and PCV13 in Phase Iib pneumococcal trial

Computer-delivered interventions do not effectively curb problematic college drinking

Physicians urged to think twice before they prescribe compounded drugs

Mother's kiss appears to be safe and effective in dislodging objects from nasal cavity of kids

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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