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The T cell responses in COVID-19 recovered individuals

A recent study demonstrates that functional CD4+ and CD8+ T cells specifically targeting the entire proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain active in individuals who have recovered from severe or mild coronavirus disease 2019 (COVID-19). Moreover, the magnitude of T cell response is correlated with the antibody response. The study is published in the journal Nature Immunology.

8 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

High levels of blood clotting factor V in severe COVID‐19 associated with worse outcomes

Patients hospitalized with severe COVID-19 infections who have high levels of the blood clotting protein factor V are at elevated risk for serious injury from blood clots such as deep vein thrombosis or pulmonary embolism, investigators at Massachusetts General Hospital (MGH) have found.

8 Sep 2020

Acne drug could be a potential treatment for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart.

8 Sep 2020

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

Inspired by the need for new and better therapies for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, Rutgers University researchers are exploring the link between uncontrolled inflammation within the brain and the brain's immune cells, known as microglia.

8 Sep 2020

Scientists discover tissue reparative role for a rare immune cell type in the gut

Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated.

8 Sep 2020

Avacta to launch Affimer-based ELISA test for SARS-CoV-2 virus detection

Avacta Group plc, the developer of Affimer biotherapeutics and reagents, is pleased to announce that it will launch an ELISA laboratory test for the SARS-CoV-2 spike protein to support global research efforts into the coronavirus that causes COVID-19.

From Avacta Life Sciences Ltd. 8 Sep 2020

Study links brain astrocyte dysfunction to Parkinson’s disease pathology

A new study using induced pluripotent stem cell technology links astrocyte dysfunction to Parkinson’s disease pathology.

8 Sep 2020

Limited gut inflammation in COVID-19

A new study by researchers at the Icahn School of Medicine at Mount Sinai and published on the preprint server medRxiv in September 2020 shows that gut infection with this virus produces primarily mucosal immunity but also a limited inflammatory response.

8 Sep 2020

Study finds strong T cell responses in patients recovered from COVID-19

Oxford University researchers have found that natural infection with COVID-19 produces a robust T cell response, including inducing T cell ‘memory’ to potentially fight future infections.

8 Sep 2020

Scientists describe various dynamic structures of the SARS-CoV-2 spike protein

Early in the pandemic, scientists uncovered the role of the ACE2 receptor in SARS-CoV-2, the virus that causes the coronavirus disease (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the angiotensin-converting enzyme 2 (ACE2) receptors act as a lock and key for cell infection.

7 Sep 2020

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

A recent study published in the preprint server medRxiv in September 2020 shows that the already approved drug families called P13K/mTOR and topoisomerase inhibitors may be useful in reducing individual susceptibility to the virus.

7 Sep 2020

Viruses play a key evolutionary role in mammals' ability to reproduce and survive

As the world scrambles to control the growing COVID-19 coronavirus pandemic, new research in Nature Structural & Molecular Biology shows viruses also play a key evolutionary role in mammals' ability to reproduce and survive.

7 Sep 2020

Study shows how mutations in DNA packaging machines can drive cancer development

Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins.

7 Sep 2020

New insights into how the brain can induce diabetes remission in rodents

In rodents with type 2 diabetes, a single surgical injection of a protein called fibroblast growth factor 1 can restore blood sugar levels to normal for weeks or months. Yet how this growth factor acts in the brain to generate this lasting benefit has been poorly understood.

7 Sep 2020

Important research on SARS-CoV-2 proteins using proximity labeling

A team of Canadian scientists has recently discovered a wide-range interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host proteins using proximity-dependent biotinylation approaches.

7 Sep 2020

Study shows how genetic data can be used to prioritize drug targets for complex diseases

An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases.

7 Sep 2020

Protein C News and Research

The T cell responses in COVID-19 recovered individuals

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

High levels of blood clotting factor V in severe COVID‐19 associated with worse outcomes

Acne drug could be a potential treatment for dilated cardiomyopathy

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

Scientists discover tissue reparative role for a rare immune cell type in the gut

Avacta to launch Affimer-based ELISA test for SARS-CoV-2 virus detection

Study links brain astrocyte dysfunction to Parkinson’s disease pathology

Limited gut inflammation in COVID-19

Study finds strong T cell responses in patients recovered from COVID-19

Scientists describe various dynamic structures of the SARS-CoV-2 spike protein

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

Viruses play a key evolutionary role in mammals' ability to reproduce and survive

Study shows how mutations in DNA packaging machines can drive cancer development

New insights into how the brain can induce diabetes remission in rodents

Important research on SARS-CoV-2 proteins using proximity labeling

Study shows how genetic data can be used to prioritize drug targets for complex diseases

A potential new way of treating Alzheimer’s Disease

D-dimer - A sensitive novel biomarker of COVID-19 mortality

Using proteins to track SARS-CoV-2 infections through wastewater

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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