Protein C News and Research

RSS

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

A new study published on the preprint server bioRxiv in September 2020 reports a novel RNA vaccine platform that shows robust protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and performs much better than a conventional mRNA vaccine. This could allow single-dose immunization, allowing progress towards global vaccination.

6 Sep 2020

Study shows SARS-CoV-2 cell receptor is a novel target of the gamma-secretase enzyme complex

Based on structural similarities with other targets of the gamma-secretase system, researchers from Columbia University Irving Medical Center in the United States show that the SARS-CoV-2 receptor for cell entry may be affected by its proteolytic activity. Their results are currently freely available in a bioRxiv preprint paper.

6 Sep 2020

Antibody responses against seasonal common cold coronaviruses may protect against SARS-CoV-2

With the use of an accurate high throughput assay, researchers from the Weizmann Institute of Science and Magen David Adom Blood Services in Israel showed substantial inter-individual variability and antibody cross-reactivity against seasonal coronaviruses upon SARS-CoV-2 infection, with important implications for immune surveys and vaccines. The study is currently available on the medRxiv* preprint server.

6 Sep 2020

Mason researchers to provide biostatistics and bioinformatic analysis for new project

Virginia Espina, Research Associate Professor, Applied Proteomics and Molecular Medicine, received $21,000 from Baylor Research Institute for a project in which Mason researchers are providing biostatistics and bioinformatic analysis for integrating multi-omic data sets from a breast cancer cohort.

5 Sep 2020

Study may provide the basis for better diagnostic, therapeutic approaches to blood diseases

The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, "heme" is produced, which in turn can influence the protein cocktail in the blood.

5 Sep 2020

Fly brain structure governed by lineage-dependent repulsion mechanism between neurons

The brain's structure has columnar features, which are hypothesized to arise from nerve cells (neurons) stemming from the same parent cell, initially forming radial units. How exactly this process unfolds at the molecular level remains unexplained, however.

5 Sep 2020

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Results from two early-phase Russian non-randomised vaccine trials (Sputnik V) in a total of 76 people are published today in The Lancet, finding that two formulations of a two-part vaccine have a good safety profile with no serious adverse events detected over 42 days, and induce antibody responses in all participants within 21 days.

5 Sep 2020

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells.

4 Sep 2020

Scientists reconstruct factors involved in the formation of autophagosomes

Autophagy, from the Greek for 'self-eating', is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited.

4 Sep 2020

Spike-based priming leads to high neutralizing activity in animal models

A new report by researchers at the University of Melbourne and published on the preprint server bioRxiv in September 2020 reports on the use of a two-protein two-dose vaccine regimen and its immunogenicity in two animal models.

4 Sep 2020

High-heat caramelization can increase risk of heart disease, stroke

From MasterChef to MKR, the world's best chefs have taught us how to barbeque, grill and panfry a steak to perfection. But while the experts may be seeking that extra flavour, new research from the University of South Australia suggests high-heat caramelization could be bad for our health.

4 Sep 2020

D614G spike mutation increases infectivity of SARS-CoV-2 and neutralization susceptibility

As the COVID-19 pandemic progresses, it is crucial to track the viral changes in order to link the clinical and epidemiological features of the disease with these mutations. A new study published on the preprint server bioRxiv* in September 2020 reports on a common severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutation, D614G, and its effects on the virus.

4 Sep 2020

Researchers identify biomarkers associated with bacterial infection mortality

David Gonzalez's "a-ha" moment came when a physician-colleague, George Sakoulas, MD, shared with him one of the biggest problems faced in clinical practice: How long it takes to diagnose a patient.

4 Sep 2020

Researchers develop novel model to study factors that cause type 2 diabetes

Using cells taken from patients with type 2 diabetes and new techniques to convert them into specialized precursors of muscle cells, researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes.

4 Sep 2020

Therapeutic derived from turmeric shows promise in treating canine ocular condition

Researchers at Texas A&M University have produced a therapeutic derived from turmeric, a spice long-praised for its natural anti-inflammatory properties, that shows promise in decreasing ocular inflammation in dogs suffering from uveitis, an inflammation of the eye that leads to pain and reduced vision.

4 Sep 2020

Research compares T cell responses to SARS-CoV-2 and influenza

As the COVID-19 pandemic continues to grow, scientists are focusing on understanding how the host immune system responds to the virus in order to better shape public health responses and develop effective vaccines. A new study published on the preprint server medRxiv in September 2020 reports the T cell memory response to the SARS-CoV-2 spike protein, recombinant nucleocapsid protein, and other pooled peptides derived from convalescent patients.

3 Sep 2020

Understanding mechanisms in prostate cancer metastases can provide treatment opportunities

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer.

3 Sep 2020

Research provides a map of coronavirus entry factors across the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases and Cornell University in the US have investigated cellular factors that could be significant for an infection.

3 Sep 2020

COVID-19 vaccine candidate protects animals against SARS-CoV-2

Most people with COVID-19 have relatively mild disease, but a subset of people develop severe pneumonia and respiratory failure, potentially leading to death.

3 Sep 2020

UChicago Medicine launches clinical trial to test the potential of antibody against SARS-CoV-2

The University of Chicago Medicine is launching a clinical trial to examine the potential of an antibody against the SARS-CoV-2 spike protein for treating COVID-19, the disease caused by the novel coronavirus.

3 Sep 2020

Protein C News and Research

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

Study shows SARS-CoV-2 cell receptor is a novel target of the gamma-secretase enzyme complex

Antibody responses against seasonal common cold coronaviruses may protect against SARS-CoV-2

Mason researchers to provide biostatistics and bioinformatic analysis for new project

Study may provide the basis for better diagnostic, therapeutic approaches to blood diseases

Fly brain structure governed by lineage-dependent repulsion mechanism between neurons

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Scientists reconstruct factors involved in the formation of autophagosomes

Spike-based priming leads to high neutralizing activity in animal models

High-heat caramelization can increase risk of heart disease, stroke

D614G spike mutation increases infectivity of SARS-CoV-2 and neutralization susceptibility

Researchers identify biomarkers associated with bacterial infection mortality

Researchers develop novel model to study factors that cause type 2 diabetes

Therapeutic derived from turmeric shows promise in treating canine ocular condition

Research compares T cell responses to SARS-CoV-2 and influenza

Understanding mechanisms in prostate cancer metastases can provide treatment opportunities

Research provides a map of coronavirus entry factors across the human body

COVID-19 vaccine candidate protects animals against SARS-CoV-2

UChicago Medicine launches clinical trial to test the potential of antibody against SARS-CoV-2

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News