Protein C News and Research

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New cellular pathway protects cells from infection by Ebola virus, coronaviruses

Discoveries from the Benaroya Research Institute at Virginia Mason (BRI) have identified a new cellular protection pathway that targets a common vulnerability in several different pandemic viruses, and collaborators at Case Western Reserve University, Boston University School of Medicine and MRIGlobal have shown that this pathway can protect cells from infection by Ebola virus and coronaviruses, like SARS-CoV-2.

28 Aug 2020

Researchers observe how two proteins operate at tricellular junctions

Organs in animals and in humans have one thing in common: they are bounded by so-called epithelial cells.

27 Aug 2020

Researchers discover how brain cancer cells evade the body's immune system

Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body's immune system.

27 Aug 2020

SARS discovery boots search for COVID-19 drugs

An extensive search and testing of current drugs and drug-like compounds has revealed compounds previously developed to fight SARS might also work against COVID-19.

27 Aug 2020

Mouse-adapted SARS-CoV-2 model helps advance the development of COVID-19 vaccines

A new COVID-19 mouse model developed at the University of North Carolina at Chapel Hill captures many of the features of human disease and has helped advance a COVID-19 vaccine candidate to clinical trial.

27 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

Researchers in Milan, Italy, have identified the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the heart tissue of deceased coronavirus disease 2019 (COVID-19) patients who had died from respiratory failure, without showing any signs of cardiac involvement.

27 Aug 2020

First lethal mouse model of SARS-CoV-2 developed

Army scientists have developed the first lethal mouse model of SARS-CoV-2, the virus that causes COVID-19, using mice that were genetically engineered to express the human ACE2 gene--a key mechanism by which the virus enters human cells.

27 Aug 2020

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

Researchers at the Universities of Maynooth and Bonn discover a new connection in muscular dystrophy Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance.

27 Aug 2020

Research identifies protein molecule that could be responsible for aggressive breast cancers

Groundbreaking cancer research by the University of South Australia has identified an invasive protein molecule that could be responsible for some of the most aggressive breast cancers.

27 Aug 2020

Exercise confers stress resilience by increasing brain protein levels

Exercise fights off stress by increasing levels of the brain protein galanin, according to research in mice recently published in JNeurosci.

27 Aug 2020

New discovery could help protect the liver from fructose-induced diseases

A team of international researchers including Monash University academics has discovered that, contrary to previous belief, fructose causes liver toxicity by changing the barrier function of the intestine.

27 Aug 2020

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation.

27 Aug 2020

Targeted therapy achieves durable objective responses Phase I/II LIBRETTO-001 trial

For patients with non-small cell lung cancers (NSCLC) marked by RET gene fusions, the targeted therapy selpercatinib was well tolerated and achieved durable objective responses, or tumor shrinkage, in the majority of participants in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

27 Aug 2020

New approach to combination drug design could be applied to disease therapies beyond diabetes

Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a heat-sensitive tether rather than simply concurrently administered.

27 Aug 2020

UKRI funding could initiate clinical trial for Cambridge-developed DNA vaccine against SARS-CoV-2

A Cambridge-developed DNA vaccine candidate against SARS-CoV-2 could begin clinical trials in the UK in late autumn or early next year, thanks to a £1.9 million award from the UK government.

27 Aug 2020

Targeting a key gateway can help treat chronic pain, shows study

Something like a quarter of the world's population suffers from chronic pain at some point. As opposed to acute pain – for example, that feeling after hitting your finger with a hammer – chronic pain may not even have a clear cause, and it can linger for years or lifetimes.

27 Aug 2020

Blood test can help predict who is likely to develop psychotic disorders

Scientists have discovered that testing the levels of certain proteins in blood samples can predict whether a person at risk of psychosis is likely to develop a psychotic disorder years later.

26 Aug 2020

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

The COVID-19 pandemic is still creating economic and health-related impact over the world. A new study published on the preprint server bioRxiv in August 2020 shows that a gp96-Ig-secreting vaccine candidate based on the expression of full-length spike protein generates a potent T cell response.

26 Aug 2020

UBC discovery may offer new treatment possibility for women with rare form of ovarian cancer

A recent finding by researchers at the BC Cancer Research Institute and the University of British Columbia may offer a new treatment possibility for people diagnosed with a rare and aggressive form of ovarian cancer.

26 Aug 2020

Protein C News and Research

New cellular pathway protects cells from infection by Ebola virus, coronaviruses

Researchers observe how two proteins operate at tricellular junctions

Researchers discover how brain cancer cells evade the body's immune system

SARS discovery boots search for COVID-19 drugs

Mouse-adapted SARS-CoV-2 model helps advance the development of COVID-19 vaccines

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

Evidence of SARS-CoV-2 coronavirus particles in heart tissue

First lethal mouse model of SARS-CoV-2 developed

Researchers find link between dystrophic muscles and lymphatic system in mice with Duchenne disease

Research identifies protein molecule that could be responsible for aggressive breast cancers

Exercise confers stress resilience by increasing brain protein levels

New discovery could help protect the liver from fructose-induced diseases

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Targeted therapy achieves durable objective responses Phase I/II LIBRETTO-001 trial

New approach to combination drug design could be applied to disease therapies beyond diabetes

UKRI funding could initiate clinical trial for Cambridge-developed DNA vaccine against SARS-CoV-2

Targeting a key gateway can help treat chronic pain, shows study

Blood test can help predict who is likely to develop psychotic disorders

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

UBC discovery may offer new treatment possibility for women with rare form of ovarian cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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