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Gold nanoparticles used to introduce chemical residues into the immune system

Developing a drug or vaccine requires a delicate balancing act with the immune system. On one hand, medications need to escape detection by the immune system in order to perform their function. But vaccinations - de-activated versions of a disease or virus - need to do the reverse. They prompt the immune system to create protective antibodies.

27 Mar 2012

New CMS requirement increases ICD placement costs

The cost to place an implantable cardioverter-defibrillator (ICD) increased by $844 per case after a new requirement from the Centers for Medicare and Medicaid Services (CMS) went into effect in February 2010, according to research presented today at the American College of Cardiology's 61st Annual Scientific Session.

27 Mar 2012

First Edition: March 27, 2012

In today's headlines, the Supreme Court chronicles continue, with reports detailing what happened during yesterday's opening-day oral arguments and previewing what's on tap for today.

27 Mar 2012

Previously unknown mechanism helps intestinal bacteria to affect formation of blood vessels

Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have discovered a previously unknown mechanism which helps intestinal bacteria to affect the formation of blood vessels. The results, which are presented in Nature, may provide future treatments of intestinal diseases and obesity.

27 Mar 2012

National biosecurity panel to hold closed-door meeting on bird flu research

The National Science Advisory Board for Biosecurity (NSABB) is scheduled this week to hold "a closed-door meeting to once again look at unpublished manuscripts describing" two studies that showed how H5N1 bird flu virus could be manipulated to become transmissible among ferrets, a model for humans, NPR's health blog "Shots" reports, noting that the meeting "will include a classified briefing from the intelligence community."

27 Mar 2012

Study reveals clinically relevant differences between on pump and off pump bypass

A large randomized trial comparing bypass surgery done with a heart-lung machine (on pump) and without it (off pump) found no differences in results between techniques overall but some clinically relevant differences, according to research presented today at the American College of Cardiology's 61st Annual Scientific Session.

27 Mar 2012

Improved clinical quality leads to decline in quality of patients' experiences

Hospitals that adopt strategies to reduce errors and meet government requirements face an initial tradeoff between improved clinical quality and a decline in the quality of individual patients' experiences, according to new research.

27 Mar 2012

U.S. has ability to help curb effects of HIV among women at home, abroad

The U.S. has "been working toward integrating HIV, sexual and reproductive health, and gender-based violence services for women overseas," and "[i]t's time we did the same at home," Serra Sippel, president of the Center for Health and Gender Equity, writes in this Huffington Post "Impact" blog post.

27 Mar 2012

Detailed CT scan can safely and quickly rule out possibility of heart attack

A highly detailed CT scan of the heart can safely and quickly rule out the possibility of a heart attack among many patients who come to hospital emergency rooms with chest pain, according to the results of a study that will be presented by researchers from the Perelman School of Medicine at the University of Pennsylvania today at the American College of Cardiology's 61st Annual Scientific Session and published concurrently in the New England Journal of Medicine.

27 Mar 2012

N.Y. seeking Medicaid waiver; Calif. adult services lawsuit now 'unsettled'

New York plans to overhaul the nation's most expensive Medicaid health care system to save $18.3 billion over five years, and will ask the federal government for half of those savings.

27 Mar 2012

Pfizer to present data on ADCs at AACR 2012

Pfizer Oncology will present data from a variety of preclinical and clinical studies of Pfizer's early-stage compounds, including data from Pfizer's investigational antibody-drug conjugate (ADC) portfolio and research evaluating several molecules targeting novel pathways that play a crucial role in basic cellular functions, at the American Association for Cancer Research (AACR) Annual Meeting 2012 in Chicago, IL, from March 31-April 4.

27 Mar 2012

Report explores expanding influence of BRICS on global health and development

Brazil, Russia, India, China and South Africa are injecting new resources, momentum and innovation into efforts to improve health in the world's poorest countries, according to a report released on the eve of the 2012 BRICS Summit. Coming as many traditional donors reduce or slow their spending, the report explores the expanding influence of the BRICS on global health and development.

27 Mar 2012

New method uses E. coli bacteria to engineer human therapeutic glycoproteins

Escherichia coli - a bacteria considered the food safety bane of restaurateurs, grocers and consumers - is a friend. Cornell University biomolecular engineers have learned to use E. coli to produce sugar-modified proteins for making pharmaceuticals cheaper and faster.

27 Mar 2012

NY-ESO-1 vaccine shows promise against ovarian cancer, melanoma

An immunotherapy regimen incorporating poxviruses and targeting a particular tumor antigen, NY-ESO-1, has shown promise in treating two types of cancers.

27 Mar 2012

Vermillion fourth quarter total revenues increase 152% to $868,000

Vermillion, Inc., a leading molecular diagnostics company, reported financial and operational results for the fourth quarter and full year ended December 31, 2011.

From Quest Diagnostics 27 Mar 2012

Teva, IVAX receive FDA approval for generic Lexapro to treat depression and GAD

The U.S. Food and Drug Administration today approved the first generic Lexapro (escitalopram tablets) to treat both depression and generalized anxiety disorder in adults.

27 Mar 2012

CBIM effective in discouraging adolescent dating violence

Male high school athletes' ability to recognize and intervene to stop dating violence -- the physical, sexual and emotional aggression prevalent in adolescent romantic relationships -- is improved with the intervention of some of the most important role models in young men's lives: their coaches.

27 Mar 2012

MedImmune receives FDA approval for FluMist Quadrivalent vaccine

FluMist Quadrivalent, a vaccine to prevent seasonal influenza in people ages 2 years through 49 years, has been approved today by the U.S. Food and Drug Administration. FluMist Quadrivalent is the first influenza vaccine to contain four strains of the influenza virus, two influenza A strains and two influenza B strains.

27 Mar 2012

New analytical method predicts maturity in premature infants

Late gestation is a busy time for babies getting ready for life outside the womb, particularly for functions critical to life such as breathing and maintaining an adequate heartbeat. These two functions are connected in mature infants and healthy people throughout life, so measuring their level of connectedness can give doctors a cue about whether an infant is ready to head home or needs to remain in the care of the neonatal intensive care unit.

27 Mar 2012

Editorials: Newspapers call for justices to dismiss challenge to health law

We don't believe the law is the threat to individual liberty that its critics claim it is. Instead, the most controversial provision - the requirement that almost all adult Americans obtain insurance coverage - is a key piece of a broad effort to fix a healthcare system that is too expensive, inefficient and inaccessible to too many Americans. The justices should dismiss the challenge to this individual mandate, as well as the other claims against the law.

27 Mar 2012