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Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

A three-drug combination that sent chronic lymphocytic leukemia (CLL) into deep remissions in a broad group of patients in a clinical trial is highly effective in patients with high-risk forms of the disease, a new, phase 2 clinical trial led by Dana-Farber Cancer Institute investigators indicates.

12 Dec 2022

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Many children with ALL have a good outcome of their disease. After two years of chemotherapy treatment, nine out of ten children are cured. But some children have a more aggressive form of the disease.

12 Dec 2022

Reports of Mpox disease following recent vaccination

The risk of infection and development of severe symptoms for Mpox remains, even after vaccination

11 Dec 2022

How convergent evolution is creating new COVID-19 waves

Researchers detail the unique evolutionary trajectory of SARS-CoV-2, with a focus on its unprecedented scale in 2022.

11 Dec 2022

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

9 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Novel gene mutation linked to rare premature-aging syndrome

UT Southwestern researchers have discovered a new form of progeria, a rare premature-aging syndrome, in a man from Malaysia and traced its cause to a novel gene mutation.

8 Dec 2022

Using Whole Exome Sequencing and Carrier Screening Tests for Birth Defects

In this interview, NewsMedical speaks with Rainu Wau from International Maternal and Children’s Hospital, Shanghai, China, about her experience using whole exome sequencing and carrier screening tests.

From BGI Genomics 8 Dec 2022

Whole genome sequencing helps construct the first blood virological profile of Chinese population

Whole genome sequencing technology can discover various known or unspecified viral sequences contained in human blood, which can provide an important database for viral infection prevention, vaccine development, viral genomic and epidemiological research.

7 Dec 2022

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

Researchers illustrated a novel strategy likely employed by viruses to promote infection.

6 Dec 2022

Laos malaria outbreak in 2020–21 likely caused by multidrug-resistant strains of P. falciparum

Researchers describe the genetic epidemiology and dynamics of the Plasmodium falciparum responsible for malaria outbreaks in Attapeu Province, Laos.

5 Dec 2022

Discovery offers an avenue for development of novel therapies for Chagas disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects some 8 million people worldwide. More than a third develop severe heart or digestive problems with a heightened risk of death.

5 Dec 2022

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

1 Dec 2022

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

The effect of evolutionary changes in prolonged SARS-CoV-2 infection in an immunosuppressed individual due to advanced HIV

Researchers assessed the impact of SARS-CoV-2 infection on cell death and fusion in an immunocompromised host.

30 Nov 2022

Mutation News and Research

Three-drug combination highly effective in patients with high-risk forms of chronic lymphocytic leukemia

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Reports of Mpox disease following recent vaccination

How convergent evolution is creating new COVID-19 waves

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Novel gene mutation linked to rare premature-aging syndrome

Using Whole Exome Sequencing and Carrier Screening Tests for Birth Defects

Whole genome sequencing helps construct the first blood virological profile of Chinese population

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

Laos malaria outbreak in 2020–21 likely caused by multidrug-resistant strains of P. falciparum

Discovery offers an avenue for development of novel therapies for Chagas disease

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

The importance of early cancer screening

INPP5D gene plays key role in enabling microglial cells to prevent plaque buildup

Specific genetic variant linked to early-onset childhood epilepsy discovered

Stem cell crosstalk with the microenvironment creates a loop of tumor-promoting factors

The effect of evolutionary changes in prolonged SARS-CoV-2 infection in an immunosuppressed individual due to advanced HIV

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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