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Study reveals mechanism that may contribute to HIV-associated metabolic conditions

HIV-infected cells release vesicles that contain a viral protein called Nef, impairing cholesterol metabolism and triggering inflammation in uninfected bystander cells, according to a study published July 25 in the open-access journal PLOS Pathogens by Dmitri Sviridov of the Baker Heart and Diabetes Institute in Australia, and colleagues.

From PLOS ONE 26 Jul 2019

EKF to showcase Lucica Glycated Albumin-L test for diabetes patient monitoring at AACC 2019

EKF Diagnostics, announces the availability of a liquid, enzymatic test for glycated albumin that was recently FDA cleared for sales in the U.S.

From EKF Diagnostics 26 Jul 2019

New biomimetic culture system enables more extensive testing of drugs and gene therapies

Researchers at the University of Louisville have developed an easily reproducible system that enables them to keep slices of human hearts alive for a longer period of time, allowing more extensive testing of new drugs and gene therapies.

26 Jul 2019

UC Davis researchers identify how diabetes increases risk of vascular diseases

A team of UC Davis Health scientists and physicians has identified a cellular connection between diabetes and one of its major complications - blood vessel narrowing that increases risks of several serious health conditions, including heart disease and stroke.

25 Jul 2019

New breast cancer drug identified as a potential therapy for glioblastoma

The Ivy Brain Tumor Center at the Barrow Neurological Institute, has released the results of its recent Phase 0 clinical trial of the breast cancer drug ribociclib (Kisqali) for the treatment of recurrent glioblastoma.

25 Jul 2019

Novel therapeutic strategy for treating Lafora Disease shows promise in preclinical study

A team of scientists have designed and tested in mice a novel and promising therapeutic strategy for treating Lafora Disease, a fatal form of childhood epilepsy.

25 Jul 2019

Study identifies new mechanism that impacts HIV infection

A team of scientists led by Texas Biomed's Assistant Professor Smita Kulkarni, Ph.D. and Mary Carrington, Ph.D., at the Frederick National Laboratory for Cancer Research, published results of a study that pinpointed a long noncoding RNA molecule which influences a key receptor involved in HIV infection and progression of the disease.

25 Jul 2019

Johns Hopkins co-leads study on 'poliolike' condition affecting children

Johns Hopkins Medicine and University of Alabama at Birmingham researchers will lead a multicenter, multinational study of acute flaccid myelitis, the “poliolike” condition affecting children that causes loss of muscle control.

From Johns Hopkins Medicine 25 Jul 2019

Study suggests how to manage blood sugar in acute stroke patients

Hyperglycemia, or high levels of glucose, is common in patients with acute ischemic stroke and is associated with worse outcomes compared with normal blood sugar levels.

25 Jul 2019

Robotic technology for spinal fusion at Norwalk Hospital helps great grandmother stay active

Lifelong Norwalk, Connecticut resident, Pat Bifano, age 75, loves to spend time with her family, including her husband Al of 56 years, four children, 12 grandchildren, and great granddaughter.

25 Jul 2019

Nanoparticles foster regenerative healing process after spinal cord injury

Paralyzing damage in spinal cord injury is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.

25 Jul 2019

Using laser-activated microrobots to deliver drug therapy

Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast.

25 Jul 2019

New vaccine shows promise against toughest HIV strains

A new study reports successful immunization against a so-far invincible “death star” strain of an HIV-related laboratory virus (SIVmac239) and another tough strain. The new approach also achieves long-term protection with a single dose, showing that gene therapy could allow broad and durable protection, based on a modified form of the CD4 protein that allows HIV entry into human cells.

24 Jul 2019

CAR-T cells used to target glioblastoma

Immunotherapy is the new weapon against cancers and building upon existing research, a team of researchers from the Massachusetts General Hospital have devised a way to make immunotherapy more effective in a deadly and common form of brain cancer called glioblastoma.

24 Jul 2019

FDA approves first nasal glucagon therapy for treatment of severe hypoglycemia

The U.S. Food and Drug Administration today approved Baqsimi nasal powder, the first glucagon therapy approved for the emergency treatment of severe hypoglycemia that can be administered without an injection.

24 Jul 2019

A lock of hair could one day aid in the diagnosis of depression in teens

It's possible that a lock of hair could one day aid in the diagnosis of depression and in efforts to monitor the effects of treatment, said the author of a new study examining cortisol levels in the hair of teens.

24 Jul 2019

Controlled stimulation of the ear canal can help reduce Parkinson's symptoms

A new study has shown that gentle, controlled stimulation of the ear canal can help reduce symptoms of Parkinson's disease.

24 Jul 2019

Measuring pupil dilation and heart rate using AI could enable earlier diagnosis of autism

Autism and other neurodevelopmental disorders often aren't diagnosed until a child is a few years of age, when behavioral interventions and speech/occupational therapy become less effective.

24 Jul 2019

Common antimalarial treatment has less effect in children with severe malnutrition

Researchers have found that severe malnutrition is associated with lower exposure to the antimalarial drug lumefantrine in children treated with artemether-lumefantrine, the most common treatment, for uncomplicated falciparum malaria.

24 Jul 2019

Researchers explore stem cells for answers to how fragile X syndrome develops

The lab of Yongchao Ma, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, discovered how the genetic defect in fragile X syndrome – a type of autism – delays production of neurons (nerve cells) at a critical time in the embryo's brain development.

24 Jul 2019