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Hearing loss, other auditory problems strongly linked with Covid-19

Hearing loss and other auditory problems are strongly associated with Covid-19 according to a systematic review of research evidence led by University of Manchester and NIHR Manchester Biomedical Research Centre (BRC) scientists.

21 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

A review of the resilience of Chinese hospitals to the COVID-19 pandemic

A new review article, published on the medRxiv* preprint server, deals with several different aspects such as medical response capability, disaster health management, disaster preparedness, and health infrastructure safety, in China, by which they survived the COVID-19 crisis.

21 Mar 2021

Genetic engineering strategy dramatically reduces tau levels in Alzheimer's animal model

Researchers have used a genetic engineering strategy to dramatically reduce levels of tau--a key protein that accumulates and becomes tangled in the brain during the development of Alzheimer's disease--in an animal model of the condition.

21 Mar 2021

FDA authorizes first machine learning-based COVID-19 non-diagnostic screening device

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the first machine learning-based Coronavirus Disease 2019 (COVID-19) non-diagnostic screening device that identifies certain biomarkers that are indicative of some types of conditions, such as hypercoagulation (a condition causing blood to clot more easily than normal).

20 Mar 2021

In-school COVID-19 transmission is rare with masking, social distancing and hand-washing

In-school COVID-19 transmission is rare - even among close school contacts of those who test positive for the virus - when schools heed public health precautions such as mandatory masking, social distancing and frequent hand-washing, according to results of a pilot study in Missouri aimed at identifying ways to keep elementary and secondary schools open and safe during the pandemic.

20 Mar 2021

Exposure to endocrine disruptors in utero associated with poorer sperm quality in adulthood

A growing number of studies show that the environmental factors and lifestyle habits of pregnant women play an important role in the health of their child. But how about the semen quality of young men?

19 Mar 2021

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

Co-founded back in 2014 by VHIO's Laura Soucek, CEO of the enterprise, and Marie-Eve Beaulieu, Chief Scientific Officer (CSO) of the company, VHIO-born spin-off Peptomyc S.L. has just announced that it has received approval from the Spanish Agency of Medicines and Medical Devices for conducting clinical trials in Spain (AEMPS), to initiate the first-in-human Phase I/II clinical trial with its first compound - a disruptive Myc inhibitor, Omomyc (OMO-103).

19 Mar 2021

Study: COVID-19 causes more severe disease and is more lethal than influenza

In a paper published in the Journal of General Internal Medicine, physician-researchers at Beth Israel Deaconess Medical Center assessed the relative impact of COVID-19 on patients hospitalized with the viral infection in March and April 2020, versus patients hospitalized with influenza during the last five flu seasons at the medical center.

19 Mar 2021

COVID-19 patients have higher risk of stroke, finds study

New research found patients hospitalized with COVID-19 had a higher risk of stroke, compared with patients who had similar infectious conditions such as influenza and sepsis in prior studies.

19 Mar 2021

Hidden genetic defects can lead to all kinds of serious illnesses

For the first time researchers from Hebrew University of Jerusalem, Radboudumc, Maastricht UMC+ and international colleagues have gained insight into the "hidden genetic defects" of the general European population.

19 Mar 2021

Blue Shield spent years cultivating a relationship with Newsom. It got the state vaccine contract.

Gavin Newsom was just making a name for himself as mayor of San Francisco in 2005 when Blue Shield of California wrote him its first major check.

19 Mar 2021

Binge drinking in adolescence associated with altered cerebellum in young adults

Binge drinking in adolescence is associated with changes in the volume of the cerebellum in young adulthood, a new study from the University of Eastern Finland and Kuopio University Hospital shows.

19 Mar 2021

Study examines efficacy of Pfizer-BioNTech mRNA COVID-19 vaccine across demographic groups

A new study examines data from Israel's vaccination campaign to assess the efficacy of the Pfizer-BioNTech mRNA vaccine across different demographics.

19 Mar 2021

Researchers characterize regions of DNA that impact MECP2 expression

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital (NRI) have identified and characterized two regions of DNA required for the proper expression of Mecp2/MECP2 in mice and humans.

19 Mar 2021

Researchers investigate the effect of COVID-19 vaccines on residents of long-term care homes

Long-term care homes have been at the epicenter of the COVID-19 pandemic in Canada, with 70 percent of COVID-19 deaths having occurred in long-term care or nursing homes.

19 Mar 2021

New drug regimen is safe and effective in children with cystic fibrosis

An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children's Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.

19 Mar 2021

Researchers find stark disparities in COVID-19 outcomes

Researchers at Seattle's Institute for Systems Biology and their collaborators looked at the electronic health records of nearly 630,000 patients who were tested for SARS-CoV-2, and found stark disparities in COVID-19 outcomes -- odds of infection, hospitalization, and in-hospital mortality -- between White and non-White minority racial and ethnic groups.

19 Mar 2021

Scientists use clinical data to study the molecular groups of atypical teratoid rhabdoid tumor

Atypical teratoid rhabdoid tumor (ATRT) is a rare brain tumor that predominantly occurs in young children. Scientists at St. Jude Children's Research Hospital used data from two clinical trials to study the molecular groups of ATRT and correlate them with clinical outcomes.

19 Mar 2021

Mass vaccination needed to protect against future resurgences of COVID-19

The first long-term seroprevalence study of residents in Wuhan, China, has found that 6.9% of people in the city had antibodies against COVID-19 in April 2020, and 82% of these people had an asymptomatic infection.

19 Mar 2021

Hospital News and Research

Hearing loss, other auditory problems strongly linked with Covid-19

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

A review of the resilience of Chinese hospitals to the COVID-19 pandemic

Genetic engineering strategy dramatically reduces tau levels in Alzheimer's animal model

FDA authorizes first machine learning-based COVID-19 non-diagnostic screening device

In-school COVID-19 transmission is rare with masking, social distancing and hand-washing

Exposure to endocrine disruptors in utero associated with poorer sperm quality in adulthood

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

Study: COVID-19 causes more severe disease and is more lethal than influenza

COVID-19 patients have higher risk of stroke, finds study

Hidden genetic defects can lead to all kinds of serious illnesses

Blue Shield spent years cultivating a relationship with Newsom. It got the state vaccine contract.

Binge drinking in adolescence associated with altered cerebellum in young adults

Study examines efficacy of Pfizer-BioNTech mRNA COVID-19 vaccine across demographic groups

Researchers characterize regions of DNA that impact MECP2 expression

Researchers investigate the effect of COVID-19 vaccines on residents of long-term care homes

New drug regimen is safe and effective in children with cystic fibrosis

Researchers find stark disparities in COVID-19 outcomes

Scientists use clinical data to study the molecular groups of atypical teratoid rhabdoid tumor

Mass vaccination needed to protect against future resurgences of COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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