Receptor News and Research

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Time (and PPAR-beta/delta) heals all wounds

Mammalian skin requires constant maintenance, but how do skin cells know when to proliferate and at what rate?

23 Mar 2009

p11 protein may lead to faster acting antidepressants

Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by current drugs.

23 Mar 2009

Tiny genetic change keeps nicotine from binding to muscle cells

A tiny genetic mutation is the key to understanding why nicotine--which binds to brain receptors with such addictive potency--is virtually powerless in muscle cells that are studded with the same type of receptor.

23 Mar 2009

Gold nanoparticles "cook" cancer cells

Researchers are describing a long-awaited advance toward applying the marvels of nanotechnology in the battle against cancer.

22 Mar 2009

New therapeutic approaches to castrate resistant prostate cancer

Today Dr. Martin Gleave of the Vancouver Prostate Centre in Canada gave a lecture about new approaches to treat castrate-resistant prostate cancer (CRCP) during the 24 th Annual Congress of the European Association of Urology in Stockholm, Sweden.

22 Mar 2009

Severe vomiting case due to chronic marijuana use

This obscure clinical manifestation of severe vomiting sickness due to chronic abuse of marijuana, recognized by Dr. Sontineni and his colleagues at the Creighton University of Omaha, NE, was published on March 14, 2009 World Journal of Gastroenterology.

22 Mar 2009

Research yields potential target for cancer, wound healing and fibrosis

Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis.

20 Mar 2009

Low to moderate drinking releases 'feel-good' endorphins in the brain, not heavy drinking

Scientists know that alcohol affects the brain, but the specifics remain unclear.

20 Mar 2009

Low dose medication best for treating high blood pressure

A newly published study found patients actually have more control of their high blood pressure (hypertension) when treated with less medication.

20 Mar 2009

Paradigm shift in the regulation of immune response

Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together.

20 Mar 2009

Lung cancer: Molecular scissors determine therapy effectiveness

In the past few years, a number of anti-cancer drugs have been developed which are directed selectively against specific key molecules of tumor cells.

17 Mar 2009

Discovery of new mechanism for the processing of endocannabinoids

New research funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, has identified a new mechanism for the processing of endocannabinoids, natural brain compounds similar to THC, the active ingredient in marijuana.

17 Mar 2009

Sensitive new test for protein detection

Scientists at the Naval Research Laboratory (NRL) recently reported the detection of toxins with unprecedented speed, sensitivity, and simplicity.

16 Mar 2009

Discovery of master switch that might prevent cancer cells from metastasizing

Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs.

16 Mar 2009

Trial of new combination treatment targeting hormone receptor-positive locally advanced breast cancer

Researchers at The Cancer Institute of New Jersey (CINJ) have opened a clinical trial, which aims to evaluate a new treatment for breast cancer in combination with one that is already approved for other types of cancers.

16 Mar 2009

Drugs throw spanner into the molecular works of enzymes

Drugs that work by blocking the function of a protein from the outside also disrupt the protein's internal workings, according to new research from the University of North Carolina at Chapel Hill.

16 Mar 2009

Dendritic cells ensure immune tolerance

One of the most important tasks of the immune system is to identify what is foreign and what is self. If this distinction fails, then the body's own structures will be attacked, the result of which could be an autoimmune disease such as diabetes mellitus type 1 or multiple sclerosis. The only way to protect against these afflictions is to destroy all immune factors that turn against the body's own tissue - in other words: immune tolerance.

16 Mar 2009

Discovery of master regulator of motor neuron firing

When the Human Genome Project was complete, DNA bowed out of the limelight and gave way to RNA as a major player in genetic regulation.

15 Mar 2009

Schering-Plough's investigational oral thrombin receptor antagonist meets primary endpoint in a newly published study

Results of a Schering-Plough Corporation Phase II trial of SCH 530348, a novel oral thrombin receptor antagonist (TRA), were published today in The Lancet and demonstrated that the investigational antiplatelet compound met its primary endpoints of safety and tolerability.

12 Mar 2009

Seniors with 1 type of heart failure may receive little or no benefit from drugs

People over 80 years of age suffering from a certain type of heart failure do not appear to benefit from most commonly prescribed heart medications, according to a study conducted at the Cedars-Sinai Heart Institute and published in the March 15 issue of The American Journal of Cardiology.

12 Mar 2009