Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Shorter telomere length of leucocytes may signal heightened dementia risk

Shorter telomeres on the ends of white blood cell chromosomes may signal a heightened dementia risk, suggest the results of a large long term study, published online in the journal General Psychiatry.

12 Sep 2023

Unlocking the future of dementia: Your telomere length could predict your risk

The recent study in General Psychiatry found that leukocyte telomere length (LTL) is significantly associated with the risk of developing dementia, especially Alzheimer's disease. Using data from over 430,000 individuals, the study suggests that telomere length could serve as a predictive biomarker for brain health and dementia risk.

12 Sep 2023

Chemotherapy drug may promote cancer growth by injuring surrounding cells

A standard chemotherapy drug injures surrounding non-cancer cells, which can then awakens dormant cancer cells and promotes cancer growth, according to a new study publishing September 12th in the open access journal PLOS Biology by Ramya Ganesan of Emory University, US, and colleagues.

12 Sep 2023

Modified adenocarcinoma classification improves reproducibility and aligns with clinical reality

A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer in Singapore.

11 Sep 2023

Color of the phlegm can indicate degree of lung inflammation in patients with bronchiectasis

The color of the phlegm from patients with the lung disease bronchiectasis can indicate the degree of inflammation in their lungs and predict their future outcomes, according to new research presented at the European Respiratory Society International Congress in Milan, Italy.

11 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Unraveling the relationship between obesity-related metabolic dysfunction and endotrophin

With obesity rates projected to continue rising globally, there is an urgent need to understand the intricate mechanisms that contribute to metabolic diseases such as diabetes.

8 Sep 2023

Blood clots may be a cause of long-term cognitive problems after COVID-19

High levels of two proteins at the time of COVID-19 have been found in patients who later experienced cognitive problems, including 'brain fog', giving a major clue as to one cause of their symptoms: blood clots.

7 Sep 2023

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

A comprehensive review in the journal Cell outlines a unified framework for classifying and validating aging biomarkers, aiming to streamline their integration into clinical research and practice. The study categorizes biomarkers into types like molecular, functional, and clinical, and sets criteria for their feasibility, validity, and applicability, all with the goal of better understanding and intervening in the aging process.

5 Sep 2023

New consensus statement provides guidance for use of 177Lu-PSMA radionuclide therapy in mCRPC patients

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has issued a new consensus statement to provide standardized guidance for the selection and management of metastatic castrate-resistant prostate cancer (mCRPC) patients being treated with 177Lu-PSMA radionuclide therapy.

5 Sep 2023

How is next-generation protein sequencing democratizing protein sequencing?

In this interview, NewsMedical speaks with Jeff Hawkins, CEO of Quantum-Si, about the challenges of conventional proteomic methods, as well as how next-generation protein sequencing is democratizing protein sequencing.

From Quantum-SI 5 Sep 2023

New tool can diagnose autism in children as young as 16 months

Results of clinical studies published simultaneously today in the Journal of the American Medical Association (JAMA) and in JAMA Network Open demonstrate that measuring children's looking behavior predicts expert clinical diagnosis of autism in children between ages 16 to 30 months tested with a high degree of accuracy.

5 Sep 2023

New blood test pinpoints Parkinson's disease through mitochondrial DNA damage

Researchers have developed a new blood test that measures mitochondrial DNA damage as a potential marker for Parkinson's disease (PD). The study shows the test could aid in diagnosing PD and assessing responses to LRRK2 kinase inhibitors, which may help in reducing mitochondrial damage in PD patients.

4 Sep 2023

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.

4 Sep 2023

Study explores the biology of post-COVID-19 cognitive deficits

Researchers explored the biology of cognitive deficits following acute COVID-19.

4 Sep 2023

New biomarker could help identify people at risk for vascular dementia

Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer's Switzerland.

4 Sep 2023

Machine learning helps identify metabolic biomarkers that could predict cancer risk

A novel study from the University of South Australia has identified a range of metabolic biomarkers that could help predict the risk of cancer.

4 Sep 2023

Marijuana users have elevated levels of cadmium and lead in their blood and urine

Recent study reveals marijuana users have elevated levels of harmful metals like cadmium and lead in their blood and urine. The findings raise questions about the long-term health impacts and the need for stronger regulation on contaminants in cannabis products.

3 Sep 2023

Amgen presents late-breaking Phase 2 olpasiran data at ESC 2023

Amgen today announced data from the final analysis of the Phase 2 OCEAN(a)-DOSE study of olpasiran, a small interfering RNA (siRNA) during the Late-Breaking Science Session at the European Society of Cardiology (ESC) Annual Meeting being held in Amsterdam. In the off-treatment extension period, olpasiran showed a lasting effect on Lp(a) reduction nearly a year after the last dose.

From AMGEN 1 Sep 2023

Alzheimer's screening just got easier, more accurate with new blood test

A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.

31 Aug 2023