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New imaging method reveals nanodomains inside ALS-linked protein droplets

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

26 Nov 2025

UBQLN2 liquid droplets emerge as key catalysts of early α-synuclein aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease.

26 Nov 2025

Shared genetic roots between delirium and Alzheimer’s disease

This study reveals genetic and proteomic risk factors for delirium, offering insights into its etiology and potential biomarkers for prediction and prevention.

26 Nov 2025

Most public speakers at FDA advisory committees support drug approval

U.S. Food and Drug Administration (FDA) advisory committees play a key role in evaluating the efficacy and safety of new drugs.

25 Nov 2025

Obesity-related metabolic stress may affect brain health far earlier than expected

For decades, scientists have known that what harms the body often harms the brain. Conditions such as obesity, high blood pressure and insulin resistance strain the body's vascular and metabolic systems.

25 Nov 2025

Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's disease

Lecanemab, sold under the name Leqembi, is a monoclonal antibody therapy for Alzheimer's disease that clears toxic amyloid plaques and delays cognitive decline.

25 Nov 2025

New skin-permeable polymer delivers insulin without needles

Innovative zwitterionic polymer facilitates insulin absorption through the skin, offering a painless alternative to injections for diabetes management.

25 Nov 2025

Unraveling the mycobiome's role in cancer

A growing body of evidence indicates that the microbiome within the gut and tumors significantly influences cancer initiation, progression, and treatment response.

25 Nov 2025

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to humans.

24 Nov 2025

Calcium-activated switch improves delivery and potency of cancer-fighting drugs

Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too often they don't make it that far.

24 Nov 2025

Discovery reveals role of EGFR in resistance to KRAS inhibitors in pancreatic cancer

A study led by University of Cincinnati Cancer Center researchers sheds new light on how pancreatic cancer cells resist treatment and points to potential new combination therapies to make treatments more effective.

24 Nov 2025

GLP-1 discontinuation associated with more weight gain and pregnancy complications

In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular weight loss GLP-1 medications before or early in their pregnancy tended to gain more weight and have higher risks of diabetes and hypertensive disorders during pregnancy, and experienced preterm delivery more so than people who had never taken GLP-1 drugs.

24 Nov 2025

Black cumin: A promising natural agent with potential against chronic diseases

Black cumin seeds contain diverse secondary metabolites, including thymoquinone, flavonoids, triterpenoids and alkaloids, that demonstrate broad antimicrobial, antioxidant, anti-inflammatory and anticancer activity. Early preclinical and limited clinical evidence shows therapeutic potential across chronic diseases, supported by mechanistic and structure activity relationship findings.

24 Nov 2025

Identifying vulnerabilities and new targets for hard-to-treat carcinomas

Some tumors are almost impossible to treat. That's especially true for carcinomas, which don't behave like other malignancies.

24 Nov 2025

Wiley adds additional data to its SmartSpectra, IR, Raman, and LC-MS libraries

Wiley expands its spectral database with over 9.5 million high-quality spectra, enhancing compound identification for researchers in various scientific fields.

From John Wiley and Sons - Scientific Publishers 24 Nov 2025

Right-handed helical motion of malaria parasites revealed

With victims numbering in the millions, malaria is an infectious disease caused by the bite of a mosquito carrying the malaria parasite.

24 Nov 2025

Most Medicaid patients do not receive life-saving drugs for opioid use disorder

A US study of more than a million Medicaid enrollees, newly diagnosed with opioid use disorder (OUD), finds most – nearly seven in 10 – are not receiving access to potentially life-saving drugs within six months.

24 Nov 2025

Dexamethasone shows potential to fight therapy-resistant breast cancer metastases

The drug dexamethasone supplements cancer treatments to alleviate side effects of chemotherapy such as nausea or inflammation.

24 Nov 2025

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Researchers showed that GLP-1 receptor agonism counteracts aging across multiple organs in mice, improving strength and reversing molecular aging signatures without meaningful effects on body weight. These benefits depended largely on hypothalamic GLP-1R signaling and closely mirrored the anti-aging patterns produced by rapamycin.

23 Nov 2025

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Drugs News and Research

New imaging method reveals nanodomains inside ALS-linked protein droplets

UBQLN2 liquid droplets emerge as key catalysts of early α-synuclein aggregation

Shared genetic roots between delirium and Alzheimer’s disease

Most public speakers at FDA advisory committees support drug approval

Obesity-related metabolic stress may affect brain health far earlier than expected

Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's disease

New skin-permeable polymer delivers insulin without needles

Unraveling the mycobiome's role in cancer

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

Calcium-activated switch improves delivery and potency of cancer-fighting drugs

Discovery reveals role of EGFR in resistance to KRAS inhibitors in pancreatic cancer

GLP-1 discontinuation associated with more weight gain and pregnancy complications

Black cumin: A promising natural agent with potential against chronic diseases

Identifying vulnerabilities and new targets for hard-to-treat carcinomas

Wiley adds additional data to its SmartSpectra, IR, Raman, and LC-MS libraries

Right-handed helical motion of malaria parasites revealed

Most Medicaid patients do not receive life-saving drugs for opioid use disorder

Dexamethasone shows potential to fight therapy-resistant breast cancer metastases

Study finds GLP-1 drugs improve strength and reverse aging biology in mice

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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