Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Cystic fibrosis carriers have higher risk for all CF-related conditions

Conventional wisdom says that having just one mutated copy of the cystic fibrosis gene has no effects on a person's health--the disease occurs when both copies of the gene are mutated. But a new study from the University of Iowa suggests that may not be the case.

8 Jan 2020

Airway Therapeutics receives funding to advance BPD treatment

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the injury cycle of inflammation for patients with respiratory and inflammatory diseases, announced today the closing of a $15.5 million oversubscribed Series C financing round.

8 Jan 2020

Interplay between relaxin and Wnt signaling has positive effects on aging heart

As a healthy heart ages, it becomes more susceptible to cardiovascular diseases. Though researchers have discovered that relaxin, an insulin-like hormone, suppresses atrial fibrillation (AF), inflammation, and fibrosis in aged rats, the underlying mechanisms of these benefits are still unknown.

7 Jan 2020

New extract can prevent nephrotoxicity caused by mycotoxin OTA

Today a team of researchers from the Department of Veterinary Medicine and Animal Production of the Federico II University of Naples, in collaboration with the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia, and the Department of Biotechnology at the University of Siena, Itay, has discovered the effectiveness of a new extract, of natural origin.

7 Jan 2020

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

The protein, called syndecan-4, combines with fellow cell membrane proteins, called integrins, to form protruding 'hands' that sense the environment outside the cell.

6 Jan 2020

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Insights into how the heart recovers after myocardial infarction (heart attack) can be obtained with a new radiotracer that targets fibroblast activity prior to it causing permanent damage.

2 Jan 2020

Pulmonary fibrosis associated with short and long sleep duration

Scientists have discovered that people who regularly sleep for more than 11 hours or less than 4 hours are 2-3 times more likely to have the incurable disease, pulmonary fibrosis, compared to those that sleep for 7 hours in a day. They attribute this association to the body clock.

30 Dec 2019

Research shows how the hepatitis D virus copies itself

A team of researchers has discovered how one crucial step occurs in the lifecycle of the hepatitis D virus (HDV), which causes the widespread and hard to treat liver inflammation called hepatitis D. The study, which was published recently in the Journal of Virology, could help develop antiviral therapy to control this disease.

22 Dec 2019

Using math equations to detect and forecast liver cancer risk

The use of mathematical modeling in the study of biological systems has become a challenging and rewarding field of research as it yields many unknown pieces of information. A new study published online on December 16, 2019, in the journal Proceedings of the National Academy of Science (PNAS).

17 Dec 2019

Tackling antibiotic resistance head-on with CRISPR

With modern advances in genetic engineering occurring almost every day, the latest discovery concerns antibiotic resistance. Using the powerful gene editor CRISPR, scientists reported the development of a gene-drive system that is 100 times as efficient as other current systems at inactivating a specific bacterial gene responsible for making the bacterium antibiotic-resistant and which is present as multiple copies within the same bacterial cell.

16 Dec 2019

New gene technology shows 100-fold efficiency in targeting antibiotic-resistant bacteria

Taking advantage of powerful advances in CRISPR gene editing, scientists at the University of California San Diego have set their sights on one of society's most formidable threats to human health.

16 Dec 2019

Study shows non-TB lung infections rising; more in women and older people

Each year, more and more people are getting mycobacterial lung infections, and the total number living with such diseases is going up, according to a new study published in the journal Annals of the American Thoracic Society. Those at greatest risk are people above the age of 65 years and the elderly.

15 Dec 2019

Molecular drills target and destroy deadly superbugs

Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again.

12 Dec 2019

Study suggests antiarrhythmic drug as potential treatment for pulmonary arterial hypertension

High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a potentially fatal disease caused by obstruction of blood flow in the lungs.

12 Dec 2019

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.

11 Dec 2019

Online decision aid provides more knowledge about the benefits of genomic sequencing

A decision aid developed to support patients undergoing genomic sequencing can reduce the amount of time patients spend speaking with overburdened genetic counselors while helping them were more knowledgeable about the benefits of sequencing, suggests a study from St. Michael's Hospital.

10 Dec 2019

Modifier gene offers a likely explanation for less infection in some patients with cystic fibrosis

Cystic fibrosis is caused by an inherited mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

10 Dec 2019

Study explores cost-effectiveness of transient elastography for detecting liver fibrosis

Non-alcoholic fatty liver diseases (NAFLD) and alcohol-related diseases (ALD) are currently the leading cause of chronic disease, cancer and mortality associated with this organ in developed countries.

10 Dec 2019

New startup aims to prevent reperfusion-related organ damage after liver transplant

Roughly 65 years ago, the first human organ transplant was successfully performed. A decade later, heart and liver transplants became possible. Now, a startup founded by researchers from the Medical University of South Carolina and elsewhere hopes to bring about the next major breakthrough.

8 Dec 2019

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a new study in the Nature journal Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

6 Dec 2019

Fibrosis News and Research

Further Reading

Cystic fibrosis carriers have higher risk for all CF-related conditions

Airway Therapeutics receives funding to advance BPD treatment

Interplay between relaxin and Wnt signaling has positive effects on aging heart

New extract can prevent nephrotoxicity caused by mycotoxin OTA

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Pulmonary fibrosis associated with short and long sleep duration

Research shows how the hepatitis D virus copies itself

Using math equations to detect and forecast liver cancer risk

Tackling antibiotic resistance head-on with CRISPR

New gene technology shows 100-fold efficiency in targeting antibiotic-resistant bacteria

Study shows non-TB lung infections rising; more in women and older people

Molecular drills target and destroy deadly superbugs

Study suggests antiarrhythmic drug as potential treatment for pulmonary arterial hypertension

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Online decision aid provides more knowledge about the benefits of genomic sequencing

Modifier gene offers a likely explanation for less infection in some patients with cystic fibrosis

Study explores cost-effectiveness of transient elastography for detecting liver fibrosis

New startup aims to prevent reperfusion-related organ damage after liver transplant

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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