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Breakthrough approaches enhance RNA delivery while minimizing inflammation

Lipid nanoparticles (LNPs) are tiny fat bubbles that are used to deliver medicines, genes, and RNA into cells. However, in some cases LNPs can cause harmful inflammation as a result of the process of RNA delivery.

11 Aug 2025

4,000-year-old sheep tooth sheds light on enigmatic Eurasian plague

Around 5,000 years ago, a mysterious form of plague spread throughout Eurasia, only to disappear 2,000 years later.

11 Aug 2025

Common food bacterium offers blueprint for safer and higher vitamin production

A new study reveals how Lactococcus lactis (L. lactis), a common food bacterium, regulates the production of a key precursor in vitamin K₂ (menaquinone) biosynthesis.

11 Aug 2025

Understanding the multifactorial causes of spina bifida

Spina bifida is among the most common and debilitating neural tube defects, affecting approximately 1 in every 2,875 newborns in the United States.

11 Aug 2025

Using machine learning framework to identify prognostic biomarkers in neuroblastoma

Neuroblastoma is the most common solid tumor in infants and accounts for nearly 15% of all pediatric cancer-related deaths.

11 Aug 2025

Epigenetic breakthrough: $200 blood test spots diabetes heart risk better than standard tools

Researchers have developed a blood-based DNA methylation risk score that predicts first macrovascular events in newly diagnosed type 2 diabetes patients more accurately than current cardiovascular risk tools. The score, when combined with clinical factors, could help target early prevention in high-risk individuals.

11 Aug 2025

Special von Economo neurons may hold key to super-sharp memory in 80+ superagers

Researchers at Northwestern University’s SuperAging Program reveal how some people over 80 retain memory performance like those decades younger, linking it to unique brain structures, reduced pathology, and lower inflammation. Their 25-year study highlights genetic, cellular, and social traits that may protect cognitive function.

10 Aug 2025

Lithium deficiency emerges as a hidden driver of Alzheimer’s

What is the earliest spark that ignites the memory-robbing march of Alzheimer’s disease? Why do some people with Alzheimer’s-like changes in the brain never go on to develop dementia? These questions have bedeviled neuroscientists for decades.

8 Aug 2025

Parents’ workplace chemical exposure may be linked to behavioral challenges in children with autism

A new study in the International Journal of Hygiene and Environmental Health finds parents' workplace chemical exposure may be linked to a range of behavioral challenges and developmental delays in their children with autism.

8 Aug 2025

New insights into how MYOD controls muscle repair and regeneration

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

8 Aug 2025

Balancing copper antimicrobials to combat antibiotic resistance

Copper has emerged as an ally in the battle against antibiotic-resistant bacteria. Copper sulfate liquids, for example, have been used since the 1700s to control fungal infections in vineyards, orchards and many other kinds of agricultural settings.

8 Aug 2025

Decoding macrophage immune responses with gene editing and machine learning

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages-immune cells that are the body's first responders-master this challenge.

8 Aug 2025

Exploring the genetic and clinical landscape of clubfoot

A new publication offers an extensive examination of clubfoot, a congenital deformity known as congenital talipes equinovarus (CTEV), affecting about 0.3% of all live births.

8 Aug 2025

Revolutionizing therapeutic protein design with synthetic biology

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious.

8 Aug 2025

RNA sequencing reveals molecular drivers for better regenerative therapies

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

8 Aug 2025

New insights into how SETD2 shapes immunity and disease

The emerging role of SETD2 in regulating immune cell function is shedding light on potential therapeutic strategies for a range of immune-related diseases.

7 Aug 2025

Understanding sex-based differences in immune system function

Many diseases affect men and women differently. Asthma tends to strike men earlier in life, yet more women develop asthma as they get older.

7 Aug 2025

CRISPR screening uncovers microproteins involved in fat storage

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

7 Aug 2025

Genetic testing can guide safer chemotherapy for gastrointestinal cancer patients

For some patients with gastrointestinal (GI) cancers like colorectal and pancreatic cancer, chemotherapy can cause severe, sometimes life-threatening side effects in those who carry certain genetic variants that can impact how their bodies process the drugs used to treat their disease.

7 Aug 2025

Researchers uncover dozens of traits driven by maternal versus paternal genes

Researchers developed a high-accuracy method to infer whether genetic variants come from the mother or father without needing parental genomes, analysing 286,666 UK Biobank participants. They uncovered over 30 parent-of-origin effects on traits from growth and metabolism to diabetes, many showing opposite effects depending on parental source.

7 Aug 2025