Membrane News and Research

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Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

In an article published in the journal Expert Opinion on Drug Safety, scientists have described the safety and efficacy profiles of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies in pregnant women with coronavirus disease 2019 (COVID-19).

13 Sep 2022

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Scientists define the immune responses against COVID-19 in HD patients who received three mRNA COVID-19 vaccine doses.

13 Sep 2022

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

It is a known fact that consuming a large amount of alcohol, even for a few days, triggers fat accumulation in the liver and ultimately leads to alcohol-related liver diseases.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Forecasting COVID-19 surges based on SARS-CoV-2 mutation surveillance

Researchers predicted surges in SARS-CoV-2 infections based on alterations in SARS-CoV-2 mutations.

13 Sep 2022

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

In a recent study posted to the medRxiv* preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7aΔ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7aΔ17del deletion (Delta-ORF7aintact) and/or the SARS-CoV-2 lineage (A.2.2).

12 Sep 2022

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

In a new study, researchers developed RK-33, a small molecule inhibitor of DDX3, and evaluated its efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs).

12 Sep 2022

Role of the transketolase-like 1 gene in the development of the modern human brain

In a new study, researchers demonstrated how transketolase-like 1 (TKTL1) gene expression influenced neocortical neurogenesis in modern humans.

12 Sep 2022

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

The immune system is equipped to respond not just to external invaders - think viruses, bacteria, and parasites - but also to internal threats, namely, cancer. Yet, frequently, malignancies overcome the immune system's defenses and evade detection.

12 Sep 2022

Duke researchers identify chlamydia’s stealthy cloaking device

Chlamydia, the leading cause of sexually transmitted bacterial infections, evades detection and elimination inside human cells by use of a cloaking device. But Duke University researchers have grasped the hem of that invisibility cloak and now hope they can pull it apart.

9 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers describe a mouse model used to generate a VH1-2 heavy chain (HC)- and Vκ1-33 light chain (LC)-based recombinant antibody that broadly neutralized all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the newly emergent Omicron sub-variant BA.5.

9 Sep 2022

Researchers review role of melatonin in pregnancies complicated by placental insufficiency

The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox

Scientists have described the epidemiology, transmission, clinical features, diagnosis, treatment, and preventive strategies of monkeypox infection among humans.

6 Sep 2022

Membrane News and Research

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Forecasting COVID-19 surges based on SARS-CoV-2 mutation surveillance

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

Role of the transketolase-like 1 gene in the development of the modern human brain

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Duke researchers identify chlamydia’s stealthy cloaking device

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers review role of melatonin in pregnancies complicated by placental insufficiency

Study provides a potential game-changer in assessing treatment response in pancreatic cancer patients

Pitt researchers describe a pathway by which cells repair damaged lysosomes

How can Legionella pneumophila transmit through the hot water plumbing of residences and office buildings?

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Recent developments in the use of nanoparticles to deliver drugs to the brain via intranasal administration

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox

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