Mutation News and Research

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Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

New research out of VCU Massey Cancer Center points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer.

30 Nov 2022

New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

Study identifies risk factors that increase Black men's susceptibility to early-onset prostate cancer

A family history of cancer and genetic variants that might be inherited appear to be important risk factors for Black men diagnosed with early-onset prostate cancer, a study involving Duke Health researchers has found.

29 Nov 2022

Blood tests may be able to guide treatment discussions for patients with metastatic cancer

As cancers grow and potentially spread to new parts of the body, they often shed cells and DNA into the blood stream. DNA can be analyzed for both the amount of DNA present and whether any potential mutations exist that may aid providers in deciding on treatments.

29 Nov 2022

Activation of microglial cells can slow down Alzheimer's progression

The brain's big-eating immune cells can slow down the progression of Alzheimer's disease. This is shown by a study that is now published in Nature Aging.

29 Nov 2022

Emory doctors join forces with the Family Heart Foundation to help patients with familial hypercholesterolemia

Doctors from the Emory Heart & Vascular Center are joining forces with the Family Heart Foundation, a leading research and advocacy organization, to find and more widely treat undiagnosed patients living with a common genetic condition that causes very high levels of unhealthy cholesterol, heightening the risk for heart attacks and strokes even at a young age.

29 Nov 2022

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Isolated monoclonal antibodies neutralize SARS-CoV-2 Delta and Omicron variants.

28 Nov 2022

Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022

Rogue killer T cells associated with leukemia drive autoimmune diseases

Gene variants associated with leukemia can produce 'rogue' immune cells that drive autoimmune diseases, according to a new study from the Garvan Institute of Medical Research.

28 Nov 2022

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer.

28 Nov 2022

Two studies emphasize the need for ethnically diverse prostate cancer genetic testing

More than 1.4 million men were diagnosed with prostate cancer in 2020 globally, but the molecular characteristics of the disease remain unexplored for the majority of patients around the world.

28 Nov 2022

BW.1- a new Omicron subvariant that escapes immunity

Researchers reports the presence of mutations that aid in immune escape in the BW.1 Omicron subvariant.

25 Nov 2022

Two new studies identify potential risk factors associated with frontotemporal dementia

Two recent studies from the University of Eastern Finland show that educational background and previous traumatic brain injury may potentially affect the risk of frontotemporal dementia.

24 Nov 2022

Duke researchers find human DNA sequence divergence after split from common ancestor of chimpanzees

A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.

24 Nov 2022

Study shows clear shifts in SARS-CoV-2 mutational spectrum during evolution

Researchers examined whether the mutational process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) itself has changed during the evolution of SARS-CoV-2.

23 Nov 2022

Ultrapotent IgM antibodies isolated from a pregnant woman with Zika virus show promise as an immunotherapy

Zika virus (ZIKV) infection is a potentially teratogenic illness, causing up to one in seven infants born to infected mothers to suffer neurodevelopmental deficits. A new study published in the journal Cell shows that some mothers escape injury to their babies because they develop a highly potent neutralizing antibody.

22 Nov 2022

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Scientists at UF Scripps Biomedical Research have developed a potential medicine for a leading cause of ALS and dementia that works by eliminating disease-causing segments of RNA. The

22 Nov 2022

Gene mutation associated with autism causes an overstimulation of brain cells

Scientists looking to understand the fundamental brain mechanisms of autism spectrum disorder have found that a gene mutation known to be associated with the disorder causes an overstimulation of brain cells far greater than that seen in neuronal cells without the mutation.

21 Nov 2022

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

Researchers demonstrated a viral amplification procedure to isolate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

21 Nov 2022

Mutation News and Research

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Inactivation of previously unknown gene found to be a likely culprit in the onset of pancreatic cancer

New guidelines for designing synthetic molecules that block interaction between two proteins

Study identifies risk factors that increase Black men's susceptibility to early-onset prostate cancer

Blood tests may be able to guide treatment discussions for patients with metastatic cancer

Activation of microglial cells can slow down Alzheimer's progression

Emory doctors join forces with the Family Heart Foundation to help patients with familial hypercholesterolemia

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Study reveals a promising therapeutic target for Alzheimer's disease

Rogue killer T cells associated with leukemia drive autoimmune diseases

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Two studies emphasize the need for ethnically diverse prostate cancer genetic testing

BW.1- a new Omicron subvariant that escapes immunity

Two new studies identify potential risk factors associated with frontotemporal dementia

Duke researchers find human DNA sequence divergence after split from common ancestor of chimpanzees

Study shows clear shifts in SARS-CoV-2 mutational spectrum during evolution

Ultrapotent IgM antibodies isolated from a pregnant woman with Zika virus show promise as an immunotherapy

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Gene mutation associated with autism causes an overstimulation of brain cells

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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