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Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

Findings of the HITCH randomized clinical trial show lack of improvement in COVID-19 on temporary androgen suppression

Researchers investigated whether temporary androgen suppression by degarelix improved the clinical outcomes among male patients hospitalized with COVID-19.

27 Apr 2022

Evidence of accelerated epigenetic age in SARS-CoV-2-positive patients

Researchers assessed the epigenetic aging in COVID-19 patients and its impact on COVID-19 severity by a genome-wide deoxyribonucleic acid methylation profiling analysis.

27 Apr 2022

How severity and progression of COVID-19 affect cytokine profiles in pregnant women

The current study deals with the results of serum cytokine analysis in a small group of pregnant women with and without COVID-19 in the third trimester in a single New York City hospital.

27 Apr 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Researchers revealed that native FokI relaxation might be induced, resulting in FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids.

27 Apr 2022

Asymptomatic SARS-CoV-2 infection among research personnel: Study

A recent research paper published in the journal Public Library of Science (PLOS) ONE analyzed asymptomatic coronavirus disease 2019 (COVID-19) in personnel engaged in academic study.

26 Apr 2022

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Researchers developed a highly pathogenic mouse-adapted SARS-CoV-2 strain to model mild, moderate, or COVID-19.

26 Apr 2022

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

In a new study, researchers evaluated antibody responses in mild cases of coronavirus disease 2019.

26 Apr 2022

Durability and neutralization capacity of SARS-CoV-2 specific antibodies in the breastmilk of convalescent COVID-19 mothers

The researchers assessed immunological and pathophysiological aspects of antenatal COVID-19.

26 Apr 2022

COVID-19 vaccine can elicit a distinct T cell-dominant immune-mediated hepatitis

In a recent study published in the Journal of Hepatology, researchers reported that the coronavirus disease 2019 (COVID-19) vaccination could elicit a distinct T cell-dominant immune-mediated hepatitis.

25 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

Treating COVID-19 using monoclonal antibodies during pregnancy

Researchers assessed the efficiency efficacy and safety of monoclonal antibodies for treating SARS-CoV-2 during pregnancy.

25 Apr 2022

Vaccine effectiveness against COVID-19 infection and related hospitalization

Researchers assessed the effectiveness of COVID-19 vaccines against COVID-19 infections and related hospitalizations.

25 Apr 2022

Within-host model for the description of SARS-CoV-2 viral dynamics in the upper respiratory tract

A team of UK-based scientists has recently developed a within-host model to determine the dynamics of SARS-CoV-2 infection in the upper respiratory tract of affected individuals.

25 Apr 2022

The challenges of Omicron

A new review published in sums up the position of Omicron as a potential threat to human health, especially in the context of controlling this pandemic.

25 Apr 2022

Monoclonal-antibody combination AZD7442 prevents COVID-19

In a recent study published in The New England Journal of Medicine, the researchers examined the monoclonal-antibody combination AZD7442 to prevent coronavirus disease 2019 (COVID-19).

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Booster vaccine provides similar protection in SARS-CoV-2 naive and convalescent individuals

Researchers estimate the effectiveness of primary vaccination and a booster dose in people with and without prior SARS-CoV-2 infection.

24 Apr 2022

Polymerase News and Research

Artificial circular RNAs found to bypass cellular antiviral responses

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

Findings of the HITCH randomized clinical trial show lack of improvement in COVID-19 on temporary androgen suppression

Evidence of accelerated epigenetic age in SARS-CoV-2-positive patients

How severity and progression of COVID-19 affect cytokine profiles in pregnant women

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Potential diagnostic method for identifying human health-relevant nucleic acids utilizing FokI-assisted digestion of DNA duplexes and DNA/RNA hybrids

Asymptomatic SARS-CoV-2 infection among research personnel: Study

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases

Durability and neutralization capacity of SARS-CoV-2 specific antibodies in the breastmilk of convalescent COVID-19 mothers

COVID-19 vaccine can elicit a distinct T cell-dominant immune-mediated hepatitis

Researchers develop new platform capable of mitochondrial DNA editing

Treating COVID-19 using monoclonal antibodies during pregnancy

Vaccine effectiveness against COVID-19 infection and related hospitalization

Within-host model for the description of SARS-CoV-2 viral dynamics in the upper respiratory tract

The challenges of Omicron

Monoclonal-antibody combination AZD7442 prevents COVID-19

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Booster vaccine provides similar protection in SARS-CoV-2 naive and convalescent individuals

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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