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Researchers secure $16 million NIH grant to investigate impact of HIV/AIDS on women

Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center today announced they received a $16 million grant from the National Institutes of Health to investigate the impact of HIV and AIDS on women.

31 Jul 2013

Researchers study how human herpes virus packages genetic information during infection

An international collaboration of researchers including Felicia Goodrum of the University of Arizona's immunobiology department has studied how a human herpes virus carried by the majority of the population packages its genetic information during infection.

31 Jul 2013

Patients with melanoma brain metastases can be treated with large doses of interleukin-2

In a retrospective study, Saint Louis University researchers have found that patients with melanoma brain metastases can be treated with large doses of interleukin-2 (HD IL-2), a therapy that triggers the body's own immune system to destroy the cancer cells.

31 Jul 2013

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

The deadly condition known as pulmonary arterial hypertension (PAH), which afflicts up to 150,000 Americans each year, may be reversible by using an inhalable gene therapy, report an international team of researchers led by investigators at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

31 Jul 2013

Study: About 50% of fibromyalgia patients have nerve damage

About half of a small group of patients with fibromyalgia - a common syndrome that causes chronic pain and other symptoms - was found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy (SFPN). Unlike fibromyalgia, which has had no known causes and few effective treatments, SFPN has a clear pathology and is known to be caused by specific medical conditions, some of which can be treated and sometimes cured.

31 Jul 2013

Male and female rats show different patterns of kidney gene expression throughout their lives

Male and female rats show different patterns of kidney gene expression throughout their lives, a study in the open access journal Biology of Sex Differences reveals. The finding could help explain some of the gender differences observed in human renal disease, and lead to improved biomarkers of kidney function.

31 Jul 2013

METH use can make person more susceptible to fungal lung infection

Methamphetamine use can make a person more susceptible to the lung infection cryptococcosis, according to a study published in mBio-, the online open-access journal of the American Society for Microbiology.

30 Jul 2013

Interferon-free treatment for genotype-1b hepatitis C patients: an interview with Professor Wulf Boecher, Boehringer Ingelheim

Genotype 1 is, worldwide, the most prevalent genotype of the hepatitis C virus. It accounts for around seventy percent of all hepatitis C infections.

30 Jul 2013

Different types of happiness have surprisingly different effects on human genome

A good state of mind - that is, your happiness - affects your genes, scientists say. In the first study of its kind, researchers from UCLA's Cousins Center for Psychoneuroimmunology and the University of North Carolina examined how positive psychology impacts human gene expression.

30 Jul 2013

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

The joints of children with the most common form of chronic inflammatory arthritis contain immune cells that resemble those of 90-year-olds, according to a new study led by researchers at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.

30 Jul 2013

Hepatocytes from stem-cell derived human liver cells increase survival of animals with liver disease

Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals.

29 Jul 2013

Technique for developing more targeted drugs using molecular "robots"

Many drugs such as agents for cancer or autoimmune diseases have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now a new study has demonstrated a technique for developing more targeted drugs, by using molecular "robots" to hone in on more specific populations of cells.

29 Jul 2013

Weekend reading: The mystery of some innovations that are slow to be accepted; myths about the obesity crisis

Why do some innovations spread so swiftly and others so slowly? Consider the very different trajectories of surgical anesthesia and antiseptics. ... On October 16, 1846, at Massachusetts General Hospital, Morton administered his gas through an inhaler in the mouth of a young man undergoing the excision of a tumor in his jaw. ... By February, anesthesia had been used in almost all the capitals of Europe, and by June in most regions of the world.

26 Jul 2013

Rapamycin extends mice lifespan but has limited effects on aging

The body's repair mechanisms begin to fail with increasing age. As a result, signs of wear and tear appear and the risk for many diseases, including Alzheimer's disease, diabetes, cardiovascular disorders and cancer, increases.

26 Jul 2013

Adaptimmune initiates Phase I/IIa open-label clinical trial in patients with ovarian cancer

Adaptimmune announced today that it has opened a Phase I/IIa, multiple-site, two-cohort, open-label clinical trial in ovarian cancer at Roswell Park Cancer Institute (RPCI) in Buffalo, N.Y., and City of Hope (COH) in Duarte, Calif.

26 Jul 2013

Zydus, IDRI partner to develop visceral leishmaniasis vaccine candidate

In a unique partnership, Zydus, India's fourth largest healthcare group and an innovation-led global healthcare provider, and IDRI, a Seattle-based non-profit research and product development organization, announced today they are collaborating on the production and clinical development of IDRI's visceral leishmaniasis vaccine candidate, designed to prevent the deadly parasitic disease.

26 Jul 2013

FDA allows marketing of Xpert MTB/RIF Assay for treatment of TB

The U.S. Food and Drug Administration today allowed marketing of the Xpert MTB/RIF Assay, the first FDA-reviewed test that can simultaneously detect bacteria that cause tuberculosis and determine if the bacteria contain genetic markers that makes them resistant to rifampin, an important antibiotic for the treatment of TB.

26 Jul 2013

First lots of 2013-2014 seasonal influenza vaccine released for U.S. distribution

Sanofi Pasteur, the vaccines division of Sanofi, announced today that the first lots of Fluzone (Influenza Virus Vaccine) for the 2013-2014 season have been released by the U.S. Food and Drug Administration for U.S. distribution and were shipped July 24.

25 Jul 2013

NIAID researchers discover monoclonal antibody can neutralize human norovirus

Researchers from the National Institute of Allergy and Infectious Diseases (NIAID) provide the first proof of concept data showing that a monoclonal antibody can neutralize human norovirus. This research, which could one day lead to effective therapies against the virus, was published online ahead of print in the Journal of Virology.

25 Jul 2013

Scientists develop simple, inexpensive and reliable method of detecting plague pathogen

Diagnosing the presence of Yersinia pestis, the cause of plague, may soon be easier than ever before. Scientists working with Peter Seeberger, Director at the Max Planck Institute of Colloids and Interfaces (MPIKG) in Potsdam and Professor at the Freie Universit-t Berlin, have come up with a simple, inexpensive and reliable method of detecting the bacterium.

25 Jul 2013

Immune System News and Research

Researchers secure $16 million NIH grant to investigate impact of HIV/AIDS on women

Researchers study how human herpes virus packages genetic information during infection

Patients with melanoma brain metastases can be treated with large doses of interleukin-2

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

Study: About 50% of fibromyalgia patients have nerve damage

Male and female rats show different patterns of kidney gene expression throughout their lives

METH use can make person more susceptible to fungal lung infection

Interferon-free treatment for genotype-1b hepatitis C patients: an interview with Professor Wulf Boecher, Boehringer Ingelheim

Different types of happiness have surprisingly different effects on human genome

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

Hepatocytes from stem-cell derived human liver cells increase survival of animals with liver disease

Technique for developing more targeted drugs using molecular "robots"

Weekend reading: The mystery of some innovations that are slow to be accepted; myths about the obesity crisis

Rapamycin extends mice lifespan but has limited effects on aging

Adaptimmune initiates Phase I/IIa open-label clinical trial in patients with ovarian cancer

Zydus, IDRI partner to develop visceral leishmaniasis vaccine candidate

FDA allows marketing of Xpert MTB/RIF Assay for treatment of TB

First lots of 2013-2014 seasonal influenza vaccine released for U.S. distribution

NIAID researchers discover monoclonal antibody can neutralize human norovirus

Scientists develop simple, inexpensive and reliable method of detecting plague pathogen

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