Antigen News and Research

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Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

A new study identified the gut microbial and immune variables linked to heterogeneous messenger ribonucleic acid (mRNA) COVID-19 vaccine responses between individuals.

11 Aug 2022

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

How much plastic was used during the COVID-19 pandemic?

In a new study, researchers estimated the amount of plastic required in a SARS-CoV-2 diagnostic assay.

10 Aug 2022

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

Researchers conducted phase 3 evaluations of the immunogenicity of the two immunization timeframes of the CoronaVac COVID-19 vaccine among Chilean adults.

10 Aug 2022

MIT researchers develop an easy-to-use test to predict Covid-19 immunity

Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection, or a combination of the two. But, just how much protection does any individual person have?

9 Aug 2022

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Researchers assess the impact of extending the interval between primary and booster COVID-19 vaccine doses.

9 Aug 2022

Double mRNA COVID-19 vaccination found to increase SARS-CoV-2 variant recognition

Researchers evaluated the impact of double BNT162b2 messenger ribonucleic acid (mRNA) vaccination in recognition of SARS-CoV-2 variants of concern.

9 Aug 2022

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

Researchers demonstrated differential utilization of the B cell germlines and SARS-CoV-2 spike protein epitopes by cross-neutralizing antibodies in infected, vaccinated and individuals with hybrid immunity.

9 Aug 2022

Powerful injectable gel provides hope for preventing glioblastoma relapse

Like the hardiest weed, glioblastoma almost always springs back - usually within months after a patient's initial brain tumor is surgically removed.

8 Aug 2022

Higher doses of CAR-T therapy achieve better survival rates for young patients with hard-to-treat B-ALL

Young people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with those who received lower doses within this range, according to research published today in Blood Advances.

8 Aug 2022

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

Researchers from Spain have identified an immune expression signature in surgical specimens associated with disease progression for non-complete pathological responders patients treated with neo adjuvant chemo-immunotherapy, which could help the follow-up and therapeutic management of these high-risk patients.

8 Aug 2022

New insights into the understanding of how ApoE variants contribute to Tau pathology in Alzheimer’s disease

Researchers examined the impact of tau neuropathology of APOE3 Christchurch (APOE3ch) homozygote against Alzheimer’s disease.

8 Aug 2022

Study tests equine polyclonal antibodies against SARS-CoV-2 variants

A recent study published tested equine polyclonal antibodies against SARS-CoV-2.

8 Aug 2022

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers demonstrated that vaccine frameworks containing deoxyribonucleic acid (DNA) origami possessing SARS-CoV-2 receptor-binding domain induce strong protective immunity.

8 Aug 2022

Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

Saliva-based self-testing platform detects SARS-CoV-2 with the same level of sensitivity as PCR tests

PCR tests, also called molecular tests or nucleic acid tests, are considered the gold standard in detecting the presence of SARS-CoV-2, the virus that gives rise to COVID-19.

5 Aug 2022

Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern

Scientists have described the identification and therapeutic evaluation of an antibody that broadly neutralizes major variants of SARS-CoV-2, including the alpha, beta, delta, and omicron variants.

5 Aug 2022

New easy-to-use test could rapidly diagnose heart attacks and cancers

Imperial researchers have built a new easy-to-use test that could diagnose non-infectious diseases like heart attacks and cancers more quickly.

4 Aug 2022

A combined influenza and COVID-19 mRNA vaccine

A combined mRNA vaccine is capable of inducing broad and durable protection against co-infection with SARS-CoV-2 and IAV,

3 Aug 2022

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.

3 Aug 2022

Antigen News and Research

Gut microbial and immune parameters linked to heterogeneous inter-personal COVID-19 vaccine-triggered immunity

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

How much plastic was used during the COVID-19 pandemic?

Study evaluates two immunization schedules for the inactivated SARS-CoV-2 vaccine Coronavac

MIT researchers develop an easy-to-use test to predict Covid-19 immunity

B-cell responses to COVID mRNA vaccine are enhanced by a 16-week interval between doses

Double mRNA COVID-19 vaccination found to increase SARS-CoV-2 variant recognition

The neutralizing activity of a panel of 482 human monoclonal antibodies against Omicron BA.4 and BA.5

Powerful injectable gel provides hope for preventing glioblastoma relapse

Higher doses of CAR-T therapy achieve better survival rates for young patients with hard-to-treat B-ALL

Researchers identify immune expression signature in surgical specimens linked to disease progression for non-CPR patients

New insights into the understanding of how ApoE variants contribute to Tau pathology in Alzheimer’s disease

Study tests equine polyclonal antibodies against SARS-CoV-2 variants

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers create a physical wiring diagram of the human immune system

Saliva-based self-testing platform detects SARS-CoV-2 with the same level of sensitivity as PCR tests

Study identifies broad-spectrum antibody that neutralizes SARS-CoV-2 variants of concern

New easy-to-use test could rapidly diagnose heart attacks and cancers

A combined influenza and COVID-19 mRNA vaccine

Persistent viral infections within hosts cause post-acute sequelae of COVID-19, research shows

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