Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Study sheds light on how vaso-occlusive pain crises arise in sickle-cell disease

One of the most common complications of sickle-cell disease occurs when deformed red blood cells clump together, blocking tiny blood vessels and causing severe pain and swelling in the affected body parts.

4 Sep 2018

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.

29 Aug 2018

Researchers identify neutrophil progenitor in the bone marrow of mice and humans

Neutrophils - short-lived, highly mobile and versatile - outnumber all other immune cells circulating through the blood stream.

29 Aug 2018

Researchers reveal an unlikely protector against growth of metastatic breast cancer

At the time of initial diagnosis, most patients with breast cancer show no signs that their cancer has spread elsewhere in the body. Yet, up to 30 percent of patients will ultimately experience metastasis, with breast cancer taking root and growing at other sites in the body, sometimes months, years or even decades later.

27 Aug 2018

Newly discovered target may prevent progression of liver injury to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.

27 Aug 2018

Researchers work to create humanized mouse model to test immunotherapies

If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies.

24 Aug 2018

Scientists work towards solving mystery of incurable blood diseases

Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes, which cause people to have immature, malfunctioning bone marrow cells that fuel a diverse set of health problems and can lead to leukemia.

23 Aug 2018

Study compares T-cell signaling patterns in two different CAR designs

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined.

21 Aug 2018

New studies point to a promising future for bioengineered teeth

Tooth loss is a significant health issue currently affecting millions of people worldwide. While artificial dental implants are the existing standard tooth replacement therapy, they do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure.

21 Aug 2018

NYU Langone's Perlmutter Cancer Center expands Blood and Marrow Transplant Program

To further advance the study and treatment of blood cancers, Perlmutter Cancer Center at NYU Langone Health has significantly expanded its Blood and Marrow Transplant Program.

20 Aug 2018

Brain tumors trap immune cells needed to fight cancer in the bone marrow, finds research

Certain brain cancers are associated with low numbers of immune system T-cells circulating in the peripheral blood. Low T-cell numbers can be a side-effect of cancer treatment. But it now appears that there is more to the story of these missing T-cells.

20 Aug 2018

Researchers describe promising strategy to remove melanoma's most powerful defenses

Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence.

16 Aug 2018

Study provides new insight into how 'trash bag of the cell' traps and seals off waste

The mechanics behind how an important process within the cell traps material before recycling it has puzzled scientists for years. But Penn State researchers have gained new insight into how this process seals off waste, much like a trash bag.

16 Aug 2018

Scripps Research scientists uncover new approach for treating thrombocytopenia

Blood platelets are like the sand bags of the body. Got a cut? Platelets pile in to clog the hole and stop the bleeding.

15 Aug 2018

Scientists identify stress hormone as key factor in failure of immune system to inhibit leukemia

The human stress hormone cortisol has been identified by scientists at the University of Kent as a key factor when the immune system fails to prevent leukemia taking hold.

14 Aug 2018

Duke researchers track missing T-cells in glioblastoma patients

Glioblastoma brain tumors can have an unusual effect on the body's immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body's defenses.

13 Aug 2018

Platelet-rich plasma does not enhance cartilage formation capabilities of stem cells

Platelet-rich plasma is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells

13 Aug 2018

NUS scientists develop new technology to customize optimal drug ‘cocktail’ for myeloma patients

A multidisciplinary team of researchers from the National University of Singapore (NUS) has developed an artificial intelligence technology platform that could potentially change the way drug combinations are being designed, hence enabling doctors to determine the most effective drug combination for a patient quickly.

13 Aug 2018

New discovery could pave way for improved leukemia treatment

Previous research has revealed that patients with acute myeloid leukemia who also have a particular mutation in a gene called NPM1 have a higher rate of remission with chemotherapy. About one-third of leukemia patients possess this favorable mutation, but until now, how it helps improve outcomes has remained unknown.

9 Aug 2018

Research uncovers new approach for expanding stem cells from umbilical cord blood

Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood.

3 Aug 2018

Bone Marrow News and Research

Further Reading

Study sheds light on how vaso-occlusive pain crises arise in sickle-cell disease

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Researchers identify neutrophil progenitor in the bone marrow of mice and humans

Researchers reveal an unlikely protector against growth of metastatic breast cancer

Newly discovered target may prevent progression of liver injury to cancer

Researchers work to create humanized mouse model to test immunotherapies

Scientists work towards solving mystery of incurable blood diseases

Study compares T-cell signaling patterns in two different CAR designs

New studies point to a promising future for bioengineered teeth

NYU Langone's Perlmutter Cancer Center expands Blood and Marrow Transplant Program

Brain tumors trap immune cells needed to fight cancer in the bone marrow, finds research

Researchers describe promising strategy to remove melanoma's most powerful defenses

Study provides new insight into how 'trash bag of the cell' traps and seals off waste

Scripps Research scientists uncover new approach for treating thrombocytopenia

Scientists identify stress hormone as key factor in failure of immune system to inhibit leukemia

Duke researchers track missing T-cells in glioblastoma patients

Platelet-rich plasma does not enhance cartilage formation capabilities of stem cells

NUS scientists develop new technology to customize optimal drug ‘cocktail’ for myeloma patients

New discovery could pave way for improved leukemia treatment

Research uncovers new approach for expanding stem cells from umbilical cord blood

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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