Gastroenterology News and Research

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Gastroenterology is the branch of medicine where the digestive system and its disorders are studied.

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

The removal of the enzyme Dnmt1 during oligodendrocyte progenitor cell (OPC) differentiation in the central nervous system resulted in inefficient myelin formation and neurological deterioration, including loss of control of bodily movements, in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal Cell Reports. The results could lead to a new understanding of multiple sclerosis and other myelin disorders in humans.

16 Apr 2016

VIEKIRAX and EXVIERA achieve high SVR rates in GT1 and GT4 hepatitis C virus infected patients

AbbVie, a global biopharmaceutical company, today announced new real-world data showing 96 percent of genotype 1 (GT1) patients (n=486/505 assessable for analysis) and 100 percent (n=53/53) of genotype 4 (GT4) patients achieved sustained virologic response at 12 weeks post-treatment (SVR12).

15 Apr 2016

Dynamic HBsAg measurements predict HBV inactivity

In patients with hepatitis B e antigen-negative chronic hepatitis B virus infection, repeated measurement of hepatitis B surface antigen during long-term follow-up can help identify those with inactive virus, suggests a chart review.

13 Apr 2016

Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

Lung ultrasound has been shown to be highly effective and safe for diagnosing pneumonia in children and a potential substitute for chest X-ray, according to a study conducted at the Icahn School of Medicine at Mount Sinai. Results are currently published in the medical journal Chest.

12 Apr 2016

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Nonalcoholic fatty liver disease, or NAFLD, comprises a group of liver disorders whose prevalence is widespread and rising. It's estimated that at least one-third of Americans have NAFLD; among obese persons, the figure is 50 percent.

6 Apr 2016

Two common approaches to post-operative AF equally safe, effective

Cleveland Clinic researchers, as part of the Cardiothoracic Surgical Trials Network, have found that two common approaches to post-operative atrial fibrillation - rhythm control and rate control - are equally safe and effective.

5 Apr 2016

Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

Six campuses of the Mount Sinai Health System - The Mount Sinai Hospital, Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West (formerly known as Mount Sinai Roosevelt), Mount Sinai Queens, and New York Eye and Ear Infirmary of Mount Sinai - have been recognized as "Leaders in LGBT Healthcare Equality" by the Human Rights Campaign (HRC) Foundation, the educational arm of the country's largest lesbian, gay, bisexual and transgender (LGBT) civil rights organization.

5 Apr 2016

UEG, ESGE outline first phase of recommendations to improve endoscopy quality standards across Europe

Every year, tens of millions of individuals across Europe undergo endoscopic procedures to assist with the diagnosis and management of gastrointestinal diseases.

31 Mar 2016

CCN5 protein reverses cardiac fibrosis in heart failure models

CCN5, a matricellular protein, has been found to reverse established cardiac fibrosis in heart failure models, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai, and Woo Jin Park, PhD, Professor of Life Sciences at the Gwangju Institute of Science and Technology, South Korea.

29 Mar 2016

Children with cardiomyopathy may benefit from family-linked treatment

A newly published national study by the Children's Hospital of Michigan and Wayne State University School of Medicine researchers shows that "parental impact and family functioning" become increasingly abnormal when children with cardiomyopathy-related chronic heart disease are more severely ill than children less affected by the disease.

24 Mar 2016

SLU researchers discover compound that disrupts fibrotic process

Saint Louis University researchers have found that a type of compound that disrupts the process that causes fibrosis (scarring) in the lungs and liver also shows promise in preventing and treating fibrosis in yet another organ, the pancreas. The research was conducted in an animal model.

23 Mar 2016

Mount Sinai Hospital uses M1 LUMI Bead loaded with doxorubicin for liver cancer treatment

An innovative cancer treatment made of luminescent chemotherapy-filled beads injected into tumors through the wrist is now available for patients with inoperable and difficult-to-treat liver cancer.

23 Mar 2016

New research links antibiotic use before age 2 to childhood obesity

While early antibiotic use has been associated with a number of rare long-term health consequences, new research links antibiotics to one of the most important and growing public health problems worldwide -- obesity.

23 Mar 2016

GEMINI LTS study: Patients with active ulcerative colitis report clinical improvements with vedolizumab treatment

Takeda Pharmaceutical Company Limited, (“Takeda”) today announced that the interim findings from the GEMINI Long-Term Safety (LTS) study were presented during the 2016 European Crohn's and Colitis Organisation (ECCO) Annual Scientific Meeting in Amsterdam, The Netherlands.

22 Mar 2016

Simple method to determine prevalence of celiac disease in children aged 2-4

Researchers from the University of Granada have developed a new, simple and non invasive method which allows to determine whether a child aged 2-4 suffers from celiac disease or not without the necessity of a blood extraction.

11 Mar 2016

Light therapy lessens depressive symptoms among cancer survivors

Light therapy decreased depressive symptoms and normalized circadian rhythms among cancer survivors, according to new research from the Icahn School of Medicine at Mount Sinai presented today at the American Psychosomatic Society in Denver, CO.

11 Mar 2016

NLRX1 protein could be new biomarker for colorectal cancer, find UNC Lineberger researchers

UNC Lineberger Comprehensive Cancer Center researchers have discovered that a deficiency in a key protein that regulates immune system warning signals could be a new biomarker for colorectal cancer, the second largest cancer killer in the United States. They believe the marker could be used to gauge response to a potential new treatment for the disease.

11 Mar 2016

Secretory capacity of human gut does not decline with age, shows study

A breakthrough in basic research and the first comprehensive study on the secretory activity of the human intestine: over a period of eight years, Dr. Dagmar Krüger of the Department of Human Biology at TU Munich has examined more than 2200 specimens from around 450 patients with bowel disease.

10 Mar 2016

Resistance to prior antiviral agents impacts TDF response

Taiwanese researchers find that virological response to tenofovir disoproxil fumarate in treatment-experienced patients with chronic hepatitis B virus infection can vary depending on the nucleos(t)ide analogue the patient is resistant to.

10 Mar 2016

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells.

9 Mar 2016

Gastroenterology News and Research

Further Reading

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

VIEKIRAX and EXVIERA achieve high SVR rates in GT1 and GT4 hepatitis C virus infected patients

Dynamic HBsAg measurements predict HBV inactivity

Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

3D MRE offers accurate non-invasive method to detect advanced fibrosis

Two common approaches to post-operative AF equally safe, effective

Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

UEG, ESGE outline first phase of recommendations to improve endoscopy quality standards across Europe

CCN5 protein reverses cardiac fibrosis in heart failure models

Children with cardiomyopathy may benefit from family-linked treatment

SLU researchers discover compound that disrupts fibrotic process

Mount Sinai Hospital uses M1 LUMI Bead loaded with doxorubicin for liver cancer treatment

New research links antibiotic use before age 2 to childhood obesity

GEMINI LTS study: Patients with active ulcerative colitis report clinical improvements with vedolizumab treatment

Simple method to determine prevalence of celiac disease in children aged 2-4

Light therapy lessens depressive symptoms among cancer survivors

NLRX1 protein could be new biomarker for colorectal cancer, find UNC Lineberger researchers

Secretory capacity of human gut does not decline with age, shows study

Resistance to prior antiviral agents impacts TDF response

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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