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Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy.

20 Nov 2022

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

In a recent study posted to the bioRxiv* preprint server, researchers developed bispecific antibodies (bsAbs), neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

17 Nov 2022

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Researchers presented a functional analysis of the SARS-CoV-2 open reading frame 3c (ORF3c) protein.

17 Nov 2022

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer.

16 Nov 2022

Scientists explore links between survival motor neuron protein and sarcopenia

Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

15 Nov 2022

Genetic differences can affect the swimming behavior of sperm cells, study shows

The behavior of sperm cells is due, in part, to the individual DNA make-up of these cells, rather than only to the genetics of males, finds a team of scientists.

15 Nov 2022

The origin of COVID-19: wildlife trade rather than laboratory leak?

A recent opinion piece published in PNAS discussed the sequence of events concerning the COVID-19 pandemic to provide evidence against the alleged leak of SARS-CoV-2 and the Ebola virus from viral research laboratories in Wuhan, China, and West Africa, respectively.

15 Nov 2022

Novel drug could help to fight both COVID-19 and cancer

While vaccination can provide life-saving protection against COVID-19, scientists are still searching for ways to treat severe infections, including in people who cannot get vaccinated or in the event that dangerous new strains of the virus arise that could bypass vaccine protection.

14 Nov 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

Researchers develop a new method to map the spatial evolution of cancers

Researchers developed a genetic clone mapping workflow centered around base-specific in situ sequencing (BaSISS) technology to derive quantitative maps of multiple genetic clones of cancer cells.

11 Nov 2022

A knowledgebase of currently known categorized COVID-19 severity variants

In a recent study posted to the medRxiv* preprint server, researchers assessed human genome variants related to the susceptibility and severity of coronavirus disease 2019 (COVID-19).

10 Nov 2022

Pitt scientists solve the mystery of how melanoma tumors control their mortality

Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality.

10 Nov 2022

New approach can help design shorter, more powerful trials to assess Parkinson’s drugs

Testing whether a new drug impacts the progression of Parkinson's disease takes years, in part because the disease often advances so slowly.

10 Nov 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022

Researchers characterize subtle differences in the brains of primates and humans

While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.

9 Nov 2022

Scientists investigate whether FSAP protein could be used as a treatment for stroke

If you have a stroke, the protein FSAP may help to reduce the extent of paralyses and problems with speech.

9 Nov 2022

Study indicates widespread SARS-CoV-2 exposure in wildlife

In a recent study posed to the bioRxiv* preprint server, researchers at Virginia Tech University investigated wildlife exposure to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).

8 Nov 2022

Researchers decipher key mechanism in the pathogenesis of juvenile Parkinson's

Parkinson's disease affects 3% of population over 65 years old, and the average age of onset is 60. Regarding juvenile Parkinson, which represents the of all Parkison's cases, the disease begins before 40 years old.

8 Nov 2022

Mutation News and Research

Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Research reveals new treatment avenue for pediatric high grade gliomas harboring a genetic mutation

Scientists explore links between survival motor neuron protein and sarcopenia

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Error-prone DNA replication and repair may lead to cancer in people with inherited BRCA1 mutations

Genetic differences can affect the swimming behavior of sperm cells, study shows

The origin of COVID-19: wildlife trade rather than laboratory leak?

Novel drug could help to fight both COVID-19 and cancer

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers develop a new method to map the spatial evolution of cancers

A knowledgebase of currently known categorized COVID-19 severity variants

Pitt scientists solve the mystery of how melanoma tumors control their mortality

New approach can help design shorter, more powerful trials to assess Parkinson’s drugs

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers characterize subtle differences in the brains of primates and humans

Scientists investigate whether FSAP protein could be used as a treatment for stroke

Study indicates widespread SARS-CoV-2 exposure in wildlife

Researchers decipher key mechanism in the pathogenesis of juvenile Parkinson's

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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