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Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

More than twelve billion doses of mRNA vaccines have been administered globally since the start of the COVID pandemic, saving millions of lives. But RNA-based therapies for other diseases have so far proven more challenging to develop.

20 Mar 2023

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell receptor heavy chain are responsible for broadening its specificity for unexposed antigens.

16 Mar 2023

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Researchers provide evidence that a novel vaccine candidate robustly neutralized SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.

16 Mar 2023

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

16 Mar 2023

Albumedix and Heartseed announce Recombumin® as a critical excipient in the manufacture of Heartseed's HS-001 investigational cell therapy as its first in-human trial commences

Albumedix Ltd, Nottingham, United Kingdom, now part of the global life science group Sartorius, and Heartseed Inc ('Heartseed'), Tokyo, Japan, Tuesday 14th March 2023, announce that Recombumin® is a critical component of Heartseed's HS-001, an investigational cardiac remuscularization cell therapy which has commenced first in human dosing.

From Albumedix Ltd. 16 Mar 2023

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

16 Mar 2023

New genetic animal model may inform potential therapeutic options for Down syndrome

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans.

14 Mar 2023

The right combination of bile salt hydrolases may offer a new approach to treat C. diff

Not all probiotics are created equal. In a new study, researchers found that certain enzymes within a class known as bile salt hydrolases (BSHs) can restrict Clostridioides difficile (C. diff.) colonization by both altering existing bile acids and by creating a new class of bile acids within the gut's microbial environment.

13 Mar 2023

Diabetes and tooth loss contribute to faster cognitive decline in older adults

Having both diabetes and tooth loss contributes to worse cognitive function and faster cognitive decline in older adults, according to a new study published in a special issue of the Journal of Dental Research focused on aging and oral health.

13 Mar 2023

New initiative aims to improve employee well-being and advance health equity in the workplace

Health inequities can be detrimental to employees' emotional, psychological and physical health and place a significant economic burden on employers.

13 Mar 2023

New discoveries made regarding autism onset in mouse models

Although autism is a common neurodevelopmental disorder, the multiple factors behind its onset are still not fully understood.

10 Mar 2023

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4) due to an autosomal recessive condition were highly susceptible to developing hypoxemic coronavirus disease 2019 (COVID-19) pneumonia when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Mar 2023

Medical device to help degenerative knee arthritis patients receives FDA approval

COTRAS Co., Ltd. (hereon referred to as COTRAS), an innovative medical-device firm focused on rehabilitation products, has secured approval from the U.S. Food and Drug Administration (FDA) for MOBILISE, a medical device to help degenerative knee arthritis patients.

8 Mar 2023

Breakthrough drug works against all the main types of primary bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Girls in Texas could get birth control at federal clinics, until a Christian father objected

On the vast Texas Panhandle, raked by wind and relentless sun, women might drive for hours to reach Haven Health, a clinic in Amarillo.

8 Mar 2023

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

Developing tailored rehabilitation strategies for brain injury patients

More than 500,000 people in the United States undergo rehabilitation following a stroke or brain injury every year.

3 Mar 2023

UK HealthCare neurologist helps to compile an essential list of MS medications

Together with Multiple Sclerosis (MS) experts, biostatisticians and clinicians from across the globe, a UK HealthCare neurologist has helped compile an essential list of MS medications for patients in resource-poor settings.

3 Mar 2023

New cell-based assay shown to rapidly profile drug resistance to three widely used SARS-CoV-2 main protease inhibiting drugs

In a recent study posted to the bioRxiv* pre-print server, researchers tested three next-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors, namely, nirmatrelvir, ensitrelvir, and FB2001, using a novel cell-based assay.

1 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

Next Generation News and Research

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Trial shows encouraging results for neoadjuvant dual immunotherapy and chemotherapy in patients with resectable NSCLC

Albumedix and Heartseed announce Recombumin® as a critical excipient in the manufacture of Heartseed's HS-001 investigational cell therapy as its first in-human trial commences

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

New genetic animal model may inform potential therapeutic options for Down syndrome

The right combination of bile salt hydrolases may offer a new approach to treat C. diff

Diabetes and tooth loss contribute to faster cognitive decline in older adults

New initiative aims to improve employee well-being and advance health equity in the workplace

New discoveries made regarding autism onset in mouse models

Individuals with autosomal and X-linked recessive deficiency of IRAK-4 and MyD88 are more susceptible to developing hypoxemic COVID-19 pneumonia

Medical device to help degenerative knee arthritis patients receives FDA approval

Breakthrough drug works against all the main types of primary bone cancer

Girls in Texas could get birth control at federal clinics, until a Christian father objected

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

Developing tailored rehabilitation strategies for brain injury patients

UK HealthCare neurologist helps to compile an essential list of MS medications

New cell-based assay shown to rapidly profile drug resistance to three widely used SARS-CoV-2 main protease inhibiting drugs

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

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