Immune System News and Research

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NIDA grants $3.3M to design vaccine conferring immunity to nicotine

A chemical component present in the nightshade family of plants is one of the world's most tenaciously addictive substances. It is the nicotine contained in tobacco and found in high concentrations in cigarettes. Smoking remains a global scourge; in the U.S. it is the leading source of preventable death.

3 Jul 2013

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data from its RNAi therapeutic program for the treatment of hemophilia and rare bleeding disorders.

2 Jul 2013

Research shows overabundance of mast cells delays wound healing

Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing.

2 Jul 2013

New mechanism triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes

Researchers at NYU Langone Medical Center have discovered a mechanism that triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes. The results, published today in Nature Immunology, suggest a common biochemical thread to multiple diseases and point the way to a new class of therapies that could treat chronic inflammation in these non-infectious diseases without crippling the immune system.

2 Jul 2013

Increased expression of Scara1 protein might impede progression of Alzheimer's disease: Study

Identification of a protein that appears to play an important role in the immune system's removal of amyloid beta (A-beta) protein from the brain could lead to a new treatment strategy for Alzheimer's disease. The report from researchers at Massachusetts General Hospital (MGH) has been published online in Nature Communications.

2 Jul 2013

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

It's a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body.

2 Jul 2013

New WHO guidelines recommend earlier treatment for people living with HIV

New HIV treatment guidelines by WHO recommend offering antiretroviral therapy earlier. Recent evidence indicates that earlier ART will help people with HIV to live longer, healthier lives, and substantially reduce the risk of transmitting HIV to others.

1 Jul 2013

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

A single systemic dose of special immune cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation, according to experts at the University of Pittsburgh School of Medicine.

1 Jul 2013

Tiny RNA molecules work as powerful regulators of immune response in mammals

A team led by scientists at The Scripps Research Institute (TSRI) has identified a family of tiny RNA molecules that work as powerful regulators of the immune response in mammals. Mice who lack these RNA molecules lose their normal infection-fighting ability, whereas mice that overproduce them develop a fatal autoimmune syndrome.

1 Jul 2013

Study shows lymphatic circulatory system may be intimately involved in vascular disorders

The often forgotten lymphatic circulatory system may be intimately involved in vascular disorders, according to a study by researchers from The University of Texas Health Science Center at Houston (UTHealth) and University of Michigan. Their research was reported recently in the Proceedings of the National Academy of Sciences.

30 Jun 2013

RPCI scientists assess safety and efficacy of immunotherapy approach to treat advanced melanoma

A new clinical research study at Roswell Park Cancer Institute (RPCI) will assess the safety and efficacy of a novel immunotherapy approach to treating advanced melanoma. Developed at RPCI by Roswell Park researchers, the investigational vaccine shows promise for treating tumors in patients with stage III/stage IV melanoma, and perhaps as a future therapy for other solid-tumor cancers as well.

30 Jun 2013

New procedure to treat acid reflux can prevent chronic rejection in lung transplant patients

A Loyola University Medical Center study suggests that a procedure to treat acid reflux could help prevent chronic rejection in lung transplant patients.

30 Jun 2013

TSRI professor receives $3.75M "mega-grants" from Russian government

Valery Fokin, professor in the Department of Chemistry at The Scripps Research Institute (TSRI), has been awarded a prestigious grant from the Russian government for $3.75 million over three years, with the possibility of a two-year renewal.

28 Jun 2013

Study: Children with Crohn's disease have enterovirus in their intestines

A new study reveals that all children with Crohn's disease that were examined had a commonly occurring virus - an enterovirus - in their intestines. This link has previously not been shown for this chronic inflammatory intestinal disorder. The findings are being published today in the latest issue of the international journal Clinical and Translational Gastroenterology.

28 Jun 2013

EMA's CHMP issues positive opinion for approval of Genzyme's LEMTRADA in Europe

Genzyme, a Sanofi company, announced today that the Committee for Medicinal Products for Human Use of the European Medicines Agency has issued a positive opinion for approval of LEMTRADA (alemtuzumab) for the treatment of adult patients with relapsing remitting multiple sclerosis with active disease defined by clinical or imaging features.

28 Jun 2013

Study reports new mechanism that regulates specification of lymphocytes

Scientists at an Academy of Finland Centre of Excellence have discovered a new mechanism regulating the immune response that can leave a person susceptible to autoimmune diseases.

28 Jun 2013

Curing type 1 diabetes: an interview with Dr. Habib Zaghouani, MU School of Medicine

Type 1 diabetes is an attack by the immune system of the islet of Langerhans within the pancreas. Basically, the islet of Langerhans harbor beta cells, which produce insulin and when the islets are attacked, the beta cells destruct and there is no more insulin. When the insulin level goes low, blood glucose levels go high and that creates a problem.

28 Jun 2013

Physician offers helpful tips to a healthy summer

Summer is officially here, and for many, so is the threat of sunburn, bug bites and allergies. Deepti Shivakumar, MD, family practice at Gottlieb Memorial Hospital, offers some helpful tips to a healthy summer.

27 Jun 2013

Children with congenital heart disease require higher levels of Vitamin D intake prior to surgery

Until now, there has been no research dedicated to the importance of Vitamin D supplementation in children with congenital heart disease (CHD). However, over the past few years, researchers at the Children's Hospital of Eastern Ontario (CHEO) Research Institute and Cardiovascular Surgery Program teamed with the Canadian Critical Care Trials Group to understand the impact of cardiac surgery on the Vitamin D status of infants and children, to be printed next month in Anesthesiology.

27 Jun 2013

Ingestion of nanoparticles at typical environmental levels unlikely to cause overt toxicity

Ingestion of commonly encountered nanoparticles at typical environmental levels is unlikely to cause overt toxicity, according to US researchers. Nevertheless there is insufficient evidence to determine whether chronic exposures could lead to subtle alterations in intestinal immune function, protein profiles, or microbial balance.

27 Jun 2013

Immune System News and Research

NIDA grants $3.3M to design vaccine conferring immunity to nicotine

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Research shows overabundance of mast cells delays wound healing

New mechanism triggers chronic inflammation in Alzheimer's, atherosclerosis and type-2 diabetes

Increased expression of Scara1 protein might impede progression of Alzheimer's disease: Study

UNC scientists use GEMMs to develop biomarkers for molecular subtypes of human breast cancer

New WHO guidelines recommend earlier treatment for people living with HIV

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

Tiny RNA molecules work as powerful regulators of immune response in mammals

Study shows lymphatic circulatory system may be intimately involved in vascular disorders

RPCI scientists assess safety and efficacy of immunotherapy approach to treat advanced melanoma

New procedure to treat acid reflux can prevent chronic rejection in lung transplant patients

TSRI professor receives $3.75M "mega-grants" from Russian government

Study: Children with Crohn's disease have enterovirus in their intestines

EMA's CHMP issues positive opinion for approval of Genzyme's LEMTRADA in Europe

Study reports new mechanism that regulates specification of lymphocytes

Curing type 1 diabetes: an interview with Dr. Habib Zaghouani, MU School of Medicine

Physician offers helpful tips to a healthy summer

Children with congenital heart disease require higher levels of Vitamin D intake prior to surgery

Ingestion of nanoparticles at typical environmental levels unlikely to cause overt toxicity

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