Genetic News and Research

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Researchers identify gene vital for post-stroke recovery

Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke. 7 out of 10 patients with these variants suffer severe sequelae three months after having a stroke, in other words, they are in a situation of dependence, compared to less than half of patients who do not present these variants.

19 Nov 2018

Cardiff University collaborates with Takeda to identify new treatment approaches for psychiatric disorders

Cardiff University has formed a drug discovery collaboration with Takeda to identify new approaches for treating schizophrenia and other psychiatric disorders.

From Takeda 19 Nov 2018

Participation project calls for relaxing research ban on germline interventions

Are genetic defects allowed to be repaired by intervening with sperm or egg cells, or even human embryos? Thanks to genetic scissors such as CRISPR/Cas, such interventions in the germline could soon become a medical reality.

19 Nov 2018

Researchers identify molecule to fight myotubular myopathy

Myotubular myopathy is a severe genetic disease that leads to muscle paralysis from birth and results in death before two years of age. Although no treatment currently exists, researchers from the University of Geneva, Switzerland, - working in collaboration with the University of Strasbourg, France, - have identified a molecule that not only greatly reduces the progression of the disease but also boosts life expectancy in animal models by a factor of seven.

19 Nov 2018

Molecular DNA analysis could facilitate more accurate prognosis, treatment of aggressive brain tumors

Meningiomas, a type of brain tumor, are usually easy to treat. However, there are a few subtypes that follow a very aggressive course and have high recurrence rates, i.e. there is a high risk of them coming back after treatment.

19 Nov 2018

Insilico Medicine to introduce 'Cure a disease in a year' program at Biodata World Congress 2018

Insilico Medicine, a Rockville-based company developing the end-to-end drug discovery and real world evidence pipeline utilizing the next generation artificial intelligence, will present its research and introduce the "Cure a disease in a year" program at the World's leading congress for big data in precision medicine - Biodata World Congress 2018.

19 Nov 2018

Scientists equip new virus that kills carcinoma cells with protein

Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells that are tricked into shielding the cancer from the immune system.

19 Nov 2018

Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

Workplace bullying or violence linked to higher risk of cardiovascular problems

People who are bullied at work or experience violence at work are at higher risk of heart and brain blood vessel problems, including heart attacks and stroke, according to the largest prospective study to investigate the link, which is published in the European Heart Journal today (Monday).

18 Nov 2018

New strategy to hinder emergence of antimicrobial-resistant pathogens

With many disease-causing bacteria ratcheting up their shields against current drugs, new tactics are vital to protect people from treatment-resistant infections.

17 Nov 2018

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy originated from cellular proliferation, not viral replication, according to new research published in Nature Communications.

17 Nov 2018

Obesity significantly increases risk of Type 2 diabetes and coronary artery disease

A Cleveland Clinic genetic analysis has found that obesity itself, not just the adverse health effects associated with it, significantly increases the risk of Type 2 diabetes and coronary artery disease. The paper was published today in the Journal of the American Medical Association Network Open.

17 Nov 2018

Personalized scheduling of radiotherapy using genetic data could reduce side effects

A new clinical study led by the University of Leicester and conducted in the HOPE clinical trials facility at Leicester's Hospitals has revealed the pivotal role that changing the time of day that a patient receives radiotherapy could play in altering radiotherapy toxicity.

16 Nov 2018

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalized treatment in the future.

16 Nov 2018

Humans play key role in distribution and transmission of Bartonella bacteria

Bartonella bacteria are disease-causing, blood-borne pathogens found in various mammal species. A study in PLOS Neglected Tropical Diseases by Hannah Frank and colleagues at Stanford University, California suggests that humans play an important role in disease risk, infection patterns, and distribution of Bartonella, advancing current understanding of Bartonella’s evolutionary history and how the bacteria may be transmitted between humans and other animal species.

16 Nov 2018

Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway

Mutations in RAS proteins initiate many of the most aggressive tumors, and the search for pharmacological inhibitors of these proteins has become a priority in the battle against cancer. Michail Steklov, Francesca Baietti, and colleagues from the Anna Sablina lab identified LZTR1 as an evolutionarily conserved component of the RAS pathway.

16 Nov 2018

New method to extend cell division and immortalization of avian-derived cells

The number of critically endangered animals has been increasing in recent years. According to data from the International Union for the Conservation of Nature, 1375 avian species are categorized as being endangered animals, and around 12% of the endangered species are avian.

16 Nov 2018

Researchers awarded $10 million grant to address root causes of asthma in Puerto Rico

Researchers at the University of California, San Francisco, National Jewish Health and Centro de Neumología Pediátrica in Puerto Rico have been awarded nearly $10 million as part of a 5-year grant from the U.S. National Heart Lung and Blood Institute, part of the National Institutes of Health, to address the root causes of asthma by studying 4,000 children in Puerto Rico, where asthma prevalence and deaths are among the highest in the world.

16 Nov 2018

Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome

Over 30 years ago, Marsha and Allen Barnett lost their sons to a puzzling childhood disease that relentlessly attacked their nervous systems and sapped their energy.

15 Nov 2018

Non-coding genetic variant plays key role in endothelial function and disease incidence

Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 people in the United States.

15 Nov 2018

Genetic News and Research

Researchers identify gene vital for post-stroke recovery

Cardiff University collaborates with Takeda to identify new treatment approaches for psychiatric disorders

Participation project calls for relaxing research ban on germline interventions

Researchers identify molecule to fight myotubular myopathy

Molecular DNA analysis could facilitate more accurate prognosis, treatment of aggressive brain tumors

Insilico Medicine to introduce 'Cure a disease in a year' program at Biodata World Congress 2018

Scientists equip new virus that kills carcinoma cells with protein

Surprising discovery about BH4 may rekindle interest in once-promising pathway

Workplace bullying or violence linked to higher risk of cardiovascular problems

New strategy to hinder emergence of antimicrobial-resistant pathogens

Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure

Obesity significantly increases risk of Type 2 diabetes and coronary artery disease

Personalized scheduling of radiotherapy using genetic data could reduce side effects

Gene editing could be used to halt kidney disease in patients with Joubert syndrome

Humans play key role in distribution and transmission of Bartonella bacteria

Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway

New method to extend cell division and immortalization of avian-derived cells

Researchers awarded $10 million grant to address root causes of asthma in Puerto Rico

Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome

Non-coding genetic variant plays key role in endothelial function and disease incidence

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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