Cancer Immunotherapy News and Research

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Research may lead the way to a simpler treatment for cancer

Sometimes too much of a good thing is not good at all. Inhibiting the function of the PD-1 protein, which blocks immune function, has shown high therapeutic efficacy in cancer immunotherapy.

10 Aug 2022

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Investigators from Cedars-Sinai Cancer have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

3 Aug 2022

Researchers use a tumor organoid system to examine bacterial effects on immunotherapy

Wake Forest Institute for Regenerative Medicine researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don't respond or develop a resistance to the treatment over time.

29 Jul 2022

Machine learning models help forecast immunotherapy response from gut microbiomes

A new research paper was published in Oncotarget on July 19, 2022, entitled, "Predicting cancer immunotherapy response from gut microbiomes using machine learning models."

20 Jul 2022

Cytokine-based cancer immunotherapy: current progress and future prospects

In this interview, News-Medical talks to Dr. Shuang Zhou about cytokine-base cancer immunotherapy, the current state of the field, and future prospects.

From Sino Biological Inc. 18 Jul 2022

The Mark Foundation for Cancer Research announces latest ASPIRE awards for eight outstanding projects

The Mark Foundation for Cancer Research announced eight outstanding research projects to receive its latest class of ASPIRE awards.

14 Jul 2022

Bacterial species known for causing diarrheal infections may also drive colorectal cancer

Data collected by researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy suggest that Clostridioides difficile, or C. diff, a bacterial species well known for causing serious diarrheal infections, may also drive colorectal cancer.

14 Jul 2022

Network-based machine learning method helps predict cancer patients' response to immunotherapy

Immunotherapy is a new cancer treatment that activates the body's immune system to fight against cancer cells without using chemotherapy or radiotherapy.

12 Jul 2022

Researchers create a comprehensive map of how complex networks of genes function together

Using new technologies to study thousands of genes simultaneously within immune cells, researchers at Gladstone Institutes, UC San Francisco (UCSF), and Stanford School of Medicine have created the most detailed map yet of how complex networks of genes function together.

11 Jul 2022

Study illustrates how the use of whole exome sequencing can better predict treatment response

Immunotherapies, such as immune checkpoint inhibitors, have transformed the treatment of advanced stage cancers.

8 Jul 2022

Scientists discover how to prevent T cell exhaustion to maintain the fight against cancer

When faced with a formidable foe for months on end, the immune system's T cells begin to tire. Whether fighting a cancer or a chronic infection, they become less effective over time, a phenomenon dubbed "T cell exhaustion" by scientists.

28 Jun 2022

New technique offers higher-precision scRNA-seq data than current technologies

The advent of single-cell RNA sequencing (scRNA-seq) has revolutionized the fields of medicine and biology by providing the ability to study the inner workings of thousands of cells at one go.

28 Jun 2022

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Colorectal, pancreatic, esophageal and stomach cancers-;some of the deadliest kinds of cancer-; have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

23 Jun 2022

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

Wistar scientists discover a new way to boost a person's immune response to tumors

Due to the development of resistance to chemotherapy and recurring tumors, patients with ovarian cancer often have low survival rates.

21 Jun 2022

Researchers demonstrate the double advantage of killer T-cells used in cancer immunotherapy

To grow, tumors rely on a specific structure, the tumor stroma. This includes blood vessels, which provide the nutrients necessary for the multiplication of diseased cells, and of lymphatic vessels, through which they migrate to metastasize.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

Synthetic IL-9 receptor allows T cells to fight cancer without the need for chemo or radiation

Before a patient can undergo T cell therapy designed to target cancerous tumors, the patient's entire immune system must be destroyed with chemotherapy or radiation. The toxic side effects are well known, including nausea, extreme fatigue and hair loss.

8 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022