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Genetic shifts in reproductive traits link to aging and health risks

This study explores the genetics of human reproductive traits, revealing links to aging, health outcomes, and longevity while highlighting the role of genetic factors in modern fertility shifts.

17 Dec 2024

Breakthrough discovery in BK polyomavirus replication offers hope for kidney transplant protection

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

6 Dec 2024

p53 mutations show diverse impact on pancreatic cancer metabolism

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

6 Dec 2024

Study sheds light on Kif23's role in embryonic brain development and microcephaly

A team of researchers from Tohoku University, the National Center of Neurology and Psychiatry, and National Yang Ming Chiao Tung University has uncovered a novel molecular mechanism through which Kif23 (a motor protein belonging to the kinesin family) plays a vital role in embryonic brain development.

5 Dec 2024

Novel single-cell genomics analysis approach provides direct insights into cell cycle and proliferation

By inferring proliferation rates from single-cell genomics, SPRINTER enhances understanding of tumor evolution and identifies key clones in cancer progression.

4 Dec 2024

Peptidomimetics as a new strategy to modulate Aurora-A and combat cancer

A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights into how it functions.

3 Dec 2024

STAG2 loss linked to increased aggression in Ewing sarcoma

Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare – 9 to 10 cases per million inhabitants per year – but it is very aggressive. 25% of patients do not respond well to regular therapy and they often experience relapses.

29 Nov 2024

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option in combination with temozolomide.

21 Nov 2024

Metabolic enzymes take on unexpected roles in cell division and DNA repair

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within the nucleus, orchestrating critical functions like cell division and DNA repair.

12 Nov 2024

Study shows how a single defective BRCA1 gene accelerates cancer development

People inherit two copies of each gene - one from each parent - an evolutionary fail-safe to ensure survival even when one of them doesn't function.

11 Nov 2024

Breakthrough research reveals how to target malignant DNA in aggressive cancers

Scientists have discovered a way to target elusive circular fragments of DNA that drive the survival of some of the most aggressive cancers, paving the way for future treatments.

9 Nov 2024

Genetic diagnosis solves medical mystery for 30 undiagnosed patients

An international team of researchers has provided a genetic diagnosis for 30 individuals whose condition was undiagnosed for years despite extensive clinical or genetic testing.

8 Nov 2024

Exploring the anticancer potential of medicinal plants

Cancer remains one of the leading global causes of mortality, with an estimated increase in cases due to lifestyle, environmental, and genetic factors.

8 Nov 2024

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

New biomarker could predict response to IBD treatment

Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process.

7 Nov 2024

Berry-flavored vapes impair lung immune response

Alterations in AM function following the exposure to berry-flavored e-cigarettes that lead to poor immune responses to pathogens and reduced host survival.

7 Nov 2024

Stanford researchers unveil the key role of extrachromosomal DNA in cancer

A trio of research papers from Stanford Medicine researchers and their international collaborators transforms scientists' understanding of how small DNA circles - until recently dismissed as inconsequential - are major drivers of many types of human cancers.

6 Nov 2024