Hypotension News and Research

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FARXIGA receives positive results in Phase III DECLARE-TIMI 58 cardiovascular outcomes trial

AstraZeneca today announced positive results from the Phase III DECLARE-TIMI 58 cardiovascular outcomes trial for FARXIGA, the broadest SGLT-2 inhibitor CVOT conducted to date.

24 Sep 2018

Epidural stimulation aids in recovery of individuals with spinal cord injury

For the first time since 2009, Stefanie Putnam is able to prepare - and eat - meals for herself, put the vest on her service dog, Kaz, and drive herself to activities with her horse without losing consciousness or gasping for breath.

17 Sep 2018

FDA approves new treatment for people with hairy cell leukemia

AstraZeneca and MedImmune, its global biologics research and development arm, announced today that the US Food and Drug Administration has approved LUMOXITI (moxetumomab pasudotox-tdfk) for the treatment of adult patients with relapsed or refractory hairy cell leukemia who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.

14 Sep 2018

Novel treatment for hairy cell leukemia approved by FDA

The U.S. Food and Drug Administration today approved Lumoxiti (moxetumomab pasudotox-tdfk) injection for intravenous use for the treatment of adult patients with relapsed or refractory hairy cell leukemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.

14 Sep 2018

Intensive blood pressure control may pose risk for serious falls and fainting, shows study

Kaiser Permanente research published today in the American Journal of Preventive Medicine found if patients with hypertension taking prescribed medications experience unusually low blood pressures -- systolic blood pressure under 110mmHg -- they are twice as likely to experience a fall or faint as patients whose treated blood pressure remains 110mmHg and above.

25 Aug 2018

CNDA approves KEYTRUDA for treatment of advanced melanoma

Merck, known as MSD outside the United States and Canada, today announced that KEYTRUDA, Merck's anti-PD-1 therapy, has been approved by the China National Drug Administration for the treatment of adult patients with unresectable or metastatic melanoma following failure of one prior line of therapy.

26 Jul 2018

Dizziness could be an early sign of dementia finds study

A new study has found that people who feel dizzy when they stand up from lying down or sitting positions, are more at risk of developing dementia or stroke. The study was published in the latest issue of the journal Neurology.

25 Jul 2018

Aggressive lowering of blood pressure reduces MCI risk, study shows

Significant reductions in the risk of mild cognitive impairment (MCI), and the combination of MCI and dementia, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer's Association International Conference 2018 in Chicago.

25 Jul 2018

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Merck, known as MSD outside the United States and Canada, announced today that the pivotal Phase 3 KEYNOTE-048 trial investigating KEYTRUDA, Merck's anti-PD-1 therapy, for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma, met a primary endpoint of overall survival as monotherapy in patients whose tumors expressed PD-L1.

25 Jul 2018

Adults with orthostatic hypotension may have undiagnosed cardiovascular disease

Orthostatic hypotension - a rapid drop in blood pressure upon standing up from a sitting or lying down position - is a frequently encountered clinical sign among patients.

3 Jul 2018

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for standard review a new supplemental Biologics License Application for KEYTRUDA, Merck's anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with resected, high-risk stage III melanoma and granted a Prescription Drug User Fee Act, or target action, date of February 16, 2019.

25 Jun 2018

Scientists develop algorithm to predict hypotension during surgery

Scientists have developed an algorithm that predicts potentially dangerous low blood pressure, or hypotension, that can occur during surgery.

11 Jun 2018

FDA approves new treatment to mitigate opioid withdrawal symptoms in adults

The U.S. Food and Drug Administration today approved Lucemyra (lofexidine hydrochloride) for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults.

17 May 2018

Study shows cardiovascular problems are more common in uterine cancer survivors

A new study in the Journal of the National Cancer Institute indicates that survivors of uterine cancer are more likely to experience cardiovascular problems years after treatment.

8 May 2018

SLU professor discovers new biomarkers for chlorine gas exposure

As experts sort through questions around recent chemical attacks in Syria, future answers to quickly testing and treating those who may have been exposed to chlorine gas may lie in chlorinated lipids, says a Saint Louis University professor.

19 Apr 2018

Increase in prehospital mortality potentially points to greater intensity of violence

A new Johns Hopkins Medicine analysis of national trauma data shows that trauma patients were four times more likely to die from gunshot wounds and nearly nine times more likely to die from stab wounds before getting to a trauma center in 2014, compared with rates in 2007.

16 Apr 2018

Patients with high-risk clinical features have greater risk for acute aortic dissection

Patients with one or more high-risk clinical features (tearing pain, hypotension, pulse deficit, neurologic deficit, new murmur) should be considered high risk for acute aortic dissection.

10 Apr 2018

Simple bedside test may help doctors diagnose certain degenerative brain diseases

A simple bedside test that matches a change in heart rate with a drop in blood pressure after a patient stands may help doctors diagnose certain degenerative brain diseases.

28 Mar 2018

Epidural stimulation can safely, effectively normalize blood pressure in patients with SCI

Patients with severe spinal cord injury (SCI) often experience chronically low blood pressure that negatively affects their health, their quality of life and their ability to engage in rehabilitative therapy.

19 Mar 2018

Perioperative beta blockers could increase deaths and strokes one year after surgery

During the 12 months after undergoing noncardiac surgery, patients with or at risk for heart disease who were treated with the beta blocker metoprolol for 30 days were less likely than patients who received a placebo to have a heart attack, but more likely to die or have a stroke, according to research presented at the American College of Cardiology's 67th Annual Scientific Session.

13 Mar 2018

Hypotension News and Research

FARXIGA receives positive results in Phase III DECLARE-TIMI 58 cardiovascular outcomes trial

Epidural stimulation aids in recovery of individuals with spinal cord injury

FDA approves new treatment for people with hairy cell leukemia

Novel treatment for hairy cell leukemia approved by FDA

Intensive blood pressure control may pose risk for serious falls and fainting, shows study

CNDA approves KEYTRUDA for treatment of advanced melanoma

Dizziness could be an early sign of dementia finds study

Aggressive lowering of blood pressure reduces MCI risk, study shows

Phase 3 study of KEYTRUDA monotherapy meets primary endpoint

Adults with orthostatic hypotension may have undiagnosed cardiovascular disease

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Scientists develop algorithm to predict hypotension during surgery

FDA approves new treatment to mitigate opioid withdrawal symptoms in adults

Study shows cardiovascular problems are more common in uterine cancer survivors

SLU professor discovers new biomarkers for chlorine gas exposure

Increase in prehospital mortality potentially points to greater intensity of violence

Patients with high-risk clinical features have greater risk for acute aortic dissection

Simple bedside test may help doctors diagnose certain degenerative brain diseases

Epidural stimulation can safely, effectively normalize blood pressure in patients with SCI

Perioperative beta blockers could increase deaths and strokes one year after surgery

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