Next generation sequencing NGS News and Research

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HRR mutational status associated with survival outcomes in recurrent platinum-sensitive ovarian cancer

Results of a biomarker analysis of the NRG Oncology NRG-GY004 trial were presented at a Seminal Session during the Society for Gynecologic Oncology's (SGO) Annual Meeting on Women's Cancer in March 2022.

19 Mar 2022

Study explores immune escape mutations caused by prolonged viral shedding in immunocompromised COVID-19 patient

A new study examined a unique case of extended viral shedding in an immunocompromised patient that produced a series of SARS-CoV-2 immune escape mutations over a seven-month period.

8 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Researchers evaluated the pathogenicity and replication potential of SARS-CoV-2 VOC Omicron lineage, BA.2 in immunocompetent mice and hamsters.

28 Feb 2022

Accelerating genomics research with the firefly

In this interview, we speak to Paul Lomax from SPT Labtech about their new firefly platform and how it will help to accelerate genomics research.

From SPT Labtech 23 Feb 2022

Pathogens in pneumonia-associated respiratory samples from Wuhan prior to SARS-CoV-2 emergence

An interesting paper in PLoS Pathogens describes the broad situation with respect to respiratory pathogens that cause acute respiratory infection (ARI) and pneumonia in the city.

21 Feb 2022

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Joint study will assess clinical value of comprehensive genomic profiling (CGP) on cancer therapy options in patients with advanced disease

From Illumina, Inc. 17 Feb 2022

Characterization of SARS-CoV-2 variants in unvaccinated and vaccinated U.S. military

Researchers discuss the genomic and virological characterization of SARS-CoV-2 variants among unvaccinated and vaccinated U.S military personnel.

16 Feb 2022

CRISPR-Cas12a assay to diagnose SARS-CoV-2 infection and detect strain-specific SNPs for variant identification

The multiplex detection approach outlined in this study has the potential to address the need to rapidly characterize the phenotype and clinical response to continually emerging SARS-CoV-2 variants as the COVID-19 pandemic continues.

16 Feb 2022

First survey on Omicron BA.2 in France

In a recent study posted to the medRxiv* preprint server, researchers described the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 21L/BA.2 Omicron variant in south-eastern France.

14 Feb 2022

SPT Labtech paves the way for a new era of genomics liquid handling with firefly® launch

SPT Labtech today announced the launch of firefly®, an innovative liquid handling platform for next-generation sequencing (NGS) library preparation.

From SPT Labtech 9 Feb 2022

Study reveals pet hamsters can acquire SARS-CoV-2 infection in real-life settings and transmit the virus back to humans

Researchers investigated the transmission of the SARS-CoV-2 Delta VOC from infected hamsters to humans.

2 Feb 2022

Study demonstrates substantial immune response in individuals infected with SARS-CoV-2 Omicron variant

Researchers analyze neutralizing antibodies against the SARS-CoV-2 VOCs with the sera of vaccinated individuals infected with the Omicron variant.

1 Feb 2022

Novel SARS-CoV-2 mutations reported in chronic HIV patients

A new study describes the emergence of new SARS-CoV-2 variants in three immunocompromised patients.

23 Jan 2022

Recombinant bat coronavirus reported in wide-ranging Cambodian bat

A new study reports on the detection of recombinant coronaviruses in several bat species in Cambodia and of a related species in China.

20 Jan 2022

Study reveals aerosol transmission of SARS-CoV-2 via floor drains

A new study investigated COVID-19 cases in an apartment complex in South Korea and explored the possibility of aerosol transmission without direct contact between infected individuals with the help of molecular phylogenetic analysis and epidemiological surveillance.

17 Jan 2022

New method for monitoring circulating SARS-CoV-2 variants and detecting new ones

To understand and act early and appropriately to emerging variants of concern, researchers have explored the possibility of having a variant-agnostic detection assay.

12 Jan 2022

Exploring the kinetics of SARS-CoV-2 Marseille-4 variant

In a new study, researchers determined the nature and dynamics of mutations associated with the SARS-CoV-2 French Marseille-4 variant during 10 months from its onset, and concluded that the heterogenicity associated with a SARS-CoV-2 lineage can possibly predict the end of an outbreak.

11 Jan 2022

Single-step RT-PCR for SARS-CoV-2 Omicron variant detection in respiratory samples

A new preprint describes a single-step molecular diagnostic test for the presence of SARS-CoV-2 infection caused by the Omicron variant that is behind the unprecedented rise in cases over the last few weeks.