Nucleotides News and Research

RSS

Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotel

The results of this study, published in the Emerging Infectious Diseases journal, underline the enhanced transmissibility of the Omicron variants of the virus, which takes advantage of small airstreams to jump to new hosts. "Our findings emphasize the importance of ventilation and integrity of building structure in quarantine facilities."

6 Nov 2022

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

The epigenetic alterations of monocytes in severe COVID-19

Researchers performed DNA methylation analysis on monocytes in the peripheral blood samples obtained from severe COVID-19 patients.

28 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

COVID-19 and the gut

Researchers summarize current knowledge about underlying mechanisms and potential therapeutic approaches for the effects of COVID-19 on the gut.

26 Oct 2022

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

In a new study, researchers visualized the mechanism of action and inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 13 (NSP13) at high spatio-temporal resolution.

13 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

ASU scientists discover an unusual RNA biogenesis pathway

For the very first time, a study led by Julian Chen and his group in Arizona State University's School of Molecular Sciences and the Biodesign Institute's Center for the Mechanism of Evolution, has discovered an unprecedented pathway producing telomerase RNA from a protein-coding messenger RNA (mRNA).

3 Oct 2022

Study investigates long-range RNA-RNA interactions of SARS-CoV-2

Researchers explored RRIs [long-range ribonucleic acid (RNA)-RNA interactions] in SARS-CoV-2 variants of concern genomes to assess evolutionary changes in SARS-CoV-2.

26 Sep 2022

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Researchers identified type 3 vaccine-derived poliovirus (VDPV) in an infant.

13 Sep 2022

Self-replicating intradermal RNA vaccine against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers assessed the efficiency of a controllable self-replicating ribonucleic acid (c-srRNA) vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

12 Sep 2022

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

The current study focused on the ability of this nmAb to neutralize Delta, Omicron, and other VOCs, as well as its efficacy when given by the intranasal route in an animal model.

1 Sep 2022

dsDNA Quantification for NGS Quality Control

Andrew Jones discusses the importance of quality control in NGS and the effect that a poorly followed protocol can have on experimental results.

From DeNovix Inc. 1 Sep 2022

The most recent evidence about phylogenesis, pathogenesis, prevention, and treatment for monkeypox

A new review sheds light on the origins of this virus and recently acquired knowledge about its disease mechanism and the preventive and therapeutic measures appropriate in this situation.

31 Aug 2022

Viruses modify host cellular machinery to produce high amounts of viral progeny

The study, published in Nature Communications, shows a new mechanism whereby viruses modify cellular machinery so that it can better read the instructions in the genome of the invading virus.

29 Aug 2022

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

In newly released research, scientists assessed the cardiac effects of remdesivir.

12 Aug 2022

Novel zoonotic Langya virus identified in China

Scientists discuss their discovery of the novel Langya henipavirus in eastern China.

11 Aug 2022

Nearly three-quarters of all stem cell lines are affected by DNA damage, say researchers

DNA damage caused by factors such as ultraviolet radiation affect nearly three-quarters of all stem cell lines derived from human skin cells, say Cambridge researchers, who argue that whole genome sequencing is essential for confirming if cell lines are usable.