Plasmid News and Research

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Doggybone DNA COVID-19 vaccine can effectively neutralize SARS-CoV-2 variants

Researchers assessed the efficacy of the novel SARS-CoV-2 doggybone deoxyribonucleic acid (DNA) vaccine.

13 Jul 2022

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

Researchers assessed the impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant.

21 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Exposure of microbial communities to antibiotics could facilitate the spread of plasmid-encoded genes

DNA molecules called plasmids – some of which protect bacteria from antibiotics – can spread rapidly through bacterial "communities" that are treated with antibiotics, new research shows.

27 May 2022

The impact of SARS-CoV-2 nucleocapsid protein mutations on the performance of rapid antigen tests

The study findings showed that the rapid antigen tests with the DMS approach could accurately identify antibody escape mutations in the SARS-CoV-2 N protein.

24 May 2022

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

Exploring the possibility of whether surface ACE2 carried by extracellular vesicles can facilitate SARS-CoV-2 infection

Researchers explored whether surface ACE2 carried by EVs can facilitate the entry of SARS-CoV-2 into host cells.

20 May 2022

Camelid IFNs could play important role in combating emerging zoonotic pathogens

In a recent study published in the Developmental & Comparative Immunology journal, the discovery of a novel form of mammalian interferon-Beta (IFN-β) with four cysteine residues from the dromedary camel and the five remaining members of the mammalian suborder Tylopoda is described.

17 May 2022

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

Scientists have discussed the possibilities of developing oral replicon-based mRNA vaccines against SARS-CoV-2.

4 May 2022

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

A novel mouse model to test SARS-CoV-2 viral infection

In a recent study posted to the Research Square* preprint server, researchers developed a novel mouse model for testing infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

26 Apr 2022

CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs

Researchers developed a clustered regularly interspaced short palindromic repeats-based diagnostic technique for detecting SARS-CoV-2 RNA.

21 Apr 2022

RNA interference triggers that target SARS-CoV-2 genome

Researchers screened ribonucleic acid interference against SARS-CoV-2.

18 Apr 2022

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

15 Apr 2022

Plasmid News and Research

Doggybone DNA COVID-19 vaccine can effectively neutralize SARS-CoV-2 variants

The impact of epistatic interactions on the ACE2 affinity in the SARS-CoV-2 Omicron variant

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Exposure of microbial communities to antibiotics could facilitate the spread of plasmid-encoded genes

The impact of SARS-CoV-2 nucleocapsid protein mutations on the performance of rapid antigen tests

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Exploring the possibility of whether surface ACE2 carried by extracellular vesicles can facilitate SARS-CoV-2 infection

Camelid IFNs could play important role in combating emerging zoonotic pathogens

Bacteria-mediated oral delivery of viral replicon-based mRNA vaccines

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

CRISPR/Cas9 deletions induce adverse on-target genomic effects

A novel mouse model to test SARS-CoV-2 viral infection

CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs

RNA interference triggers that target SARS-CoV-2 genome

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Nanocell COVID-19 vaccine elicits potent neutralizing response

Researchers seek to understand how microbes in the GI tract help people resist pathogens

Study detects SARS-CoV-2 BA.1/BA.2 recombinant in two epidemiologically linked cases

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Mastering plasmid production for genetic engineering and therapeutic research eBook

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Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics