Signaling Pathway News and Research

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Study identifies C1orf122 as prognostic marker in liver cancer

Primary liver cancer is the third leading cause of cancer-related deaths, of which hepatocellular carcinoma (HCC) accounts for approximately 90% of all liver cancer cases.

11 Sep 2025

Piezo1 identified as key trigger for tension driven skin expansion

Investigators at Johns Hopkins Medicine report new evidence that the protein Piezo1 controls skin growth by detecting when skin is stretched and then coordinating the metabolic and immune changes necessary for growth.

5 Sep 2025

Smoking fuels pancreatic cancer growth through immune suppression

A new study explains why smokers have a higher chance of developing pancreatic cancer and why they tend to have worse outcomes than nonsmokers.

4 Sep 2025

Can oral bacteria make heart disease worse?

The presence of viridans streptococci in coronary plaques indicates a role in atherosclerosis, potentially influencing heart disease outcomes.

1 Sep 2025

New molecular mechanism offers hope for treating depression in the elderly

Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes have still not been clearly identified.

25 Aug 2025

Researchers identify molecular mechanism behind tamoxifen-related uterine cancer

In a preclinical study, researchers found tamoxifen encourages uterine cell growth; the findings could change how some breast cancers are treated in the future.

22 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Ciliary Hedgehog signaling controls the fate of fat precursor cells

Too much fat can be unhealthy: how fat cells, so-called adipocytes, develop, is crucial for the function of the fat tissue.

20 Aug 2025

Improving gene therapy safety with human kidney organoids

Ryuji Morizane, MD, PhD, of the Department of Medicine at Massachusetts General Hospital, is the senior/corresponding author of a new paper published in Signal Transduction and Targeted Therapy, "AAV for gene therapy drives a nephrotoxic response via NFκB in kidney organoids."

19 Aug 2025

Why zinc may be the missing nutrient in childhood asthma care

The role of zinc in childhood asthma is critical; deficiency may worsen symptoms, while supplementation could provide a safe, effective treatment alternative.

19 Aug 2025

RNA quality control protein PELOTA found to slow aging and extend lifespan

As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases.

18 Aug 2025

Respiratory viruses awaken dormant breast cancer cells and raise relapse risk

Respiratory viruses such as influenza and COVID-19 can reactivate dormant breast cancer cells in the lungs, raising the risk of metastasis. The process is driven by IL-6–induced cell changes and immune suppression, with the highest recurrence risk soon after infection.

14 Aug 2025

How circadian biology shapes intestinal regeneration and health

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated.

14 Aug 2025

Aging weakens blood-brain barrier and impairs memory

A new study from researchers at the University of Illinois Chicago reveals how the blood-brain barrier gets leakier with age, contributing to memory deficits.

12 Aug 2025

Decoding macrophage immune responses with gene editing and machine learning

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages-immune cells that are the body's first responders-master this challenge.

8 Aug 2025

Exploring the genetic and clinical landscape of clubfoot

A new publication offers an extensive examination of clubfoot, a congenital deformity known as congenital talipes equinovarus (CTEV), affecting about 0.3% of all live births.

8 Aug 2025

Creatine in your diet may benefit your digestive system

Findings suggest dietary creatine from meat may alleviate chronic constipation, with stronger effects observed in men and those without certain health issues.

4 Aug 2025

AI-designed protein activates Notch signaling pathway to boost T-cell production

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.

1 Aug 2025

Researchers classify how specific genetic mutations correspond to rare disorders

The NF-κB signaling pathway plays a pivotal role in how our bodies fight infection, heal, and regulate inflammation. At the heart of this pathway is the NEMO protein, encoded by the IKBKG gene.

30 Jul 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025