Ubiquitin News and Research

RSS

Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Study reveals role of corpora amylacea in expelling brain waste substances

An article published in Proceedings of the National Academy of Sciences describes a new pathway in the central nervous system to expel waste substances from the brain through the creation of corpora amylacea, aggregates formed by glucose polymers amassing waste products.

4 Dec 2019

Scientists sheds light on small protein and its role in immune response

The immune system is the body’s defense against disease-causing pathogens. It works by warding off disease and potentially-damaging foreign bodies. Now, a team of researchers have developed a new method to shed light on the basic defense mechanism of the immune system.

27 Nov 2019

New strategy could help cells get rid of disease-related debris

Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases.

27 Nov 2019

Discovery may provide clues for treatment of autism and schizophrenia

Researchers at the Case Western Reserve University School of Medicine have identified that a gene critical to clearing up unnecessary proteins plays a role in brain development and contributes to the development of autism spectrum disorders and schizophrenia.

25 Nov 2019

Discovery may lead to possible treatments for autism spectrum disorders, schizophrenia

25 Nov 2019

Study: MIB2 improves inflammation by degrading CYLD enzyme

The tumor suppressor CYLD lysine 63 deubiquitinase (CYLD) is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway.

30 Oct 2019

Researchers obtain 3D structural snapshots of key regulator of cell biology

Some of the greatest insights into cancer and how to treat it come when basic scientists and cancer biologists and clinicians collaborate.

17 Oct 2019

€7.6 million ERC Synergy grant to support research on molecular mechanisms of viral infection

The interdisciplinary team wants to investigate the molecular mechanisms of viral infection, which will contribute to fundamental knowledge about cellular regulation and new concepts for broad-spectrum anti-viral therapy. The funding amounts to 7.6 million euros.

11 Oct 2019

Researchers find a weak spot in cancer cells

Cancer cells form tumors. This statement, simple as it seems, hides a complex failure of normal immune responses that should eliminate tumor cells from the body before they ever form viable cancer masses.

28 Aug 2019

Study shows microRNA can protect the heart from reperfusion injury

Heart muscle can continue to die even after restoring blood following a heart attack, and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form.

27 Aug 2019

Boehringer Ingelheim and University of Dundee extend collaboration to develop new cancer medicines

Following the success of their ongoing alliance, Boehringer Ingelheim and the University of Dundee extend their collaboration to develop new medicines that target and destroy key cancer causing proteins.

12 Jun 2019

Study uncovers how simpler organisms manage recycling of incomplete proteins

Our cells' process for transforming genes into useful proteins works much like an automobile factory's assembly line; there are schematics, parts, workers, motors, quality control systems and even recycling crews.

31 May 2019

PCRF awards £1.2M grants for new research projects tackling pancreatic cancer

Seven innovative research projects tackling pancreatic cancer have been awarded grants totalling £1.2M by the UK medical research charity, Pancreatic Cancer Research Fund.

28 May 2019

Scientists unravel how DNA organizes and preserves genetic information

Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information.

From Johns Hopkins Medicine 22 May 2019

Researchers identify new molecular mechanism causing rheumatoid arthritis

A collaborative study by research groups from the University of Cologne, VIB, Ghent University, the Βiomedical Sciences Research Center 'Alexander Fleming' in Athens and the University of Tokyo identified a new molecular mechanism causing rheumatoid arthritis.

14 May 2019

Damaged mitochondria use 'eat me' signals for mitophagy

When mitochondria become damaged, they avoid causing further problems by signaling cellular proteins to degrade them.

12 Apr 2019

Scientists develop technique to clear abnormal tau protein from human neurons

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

10 Apr 2019