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Repeated exposure to anesthesia early in life causes long-term behavioral changes

Repeated exposure to anesthesia early in life causes alterations in emotional behavior that may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai in collaboration with the Yerkes National Primate Research Center, and published in the Online First edition of Anesthesiology, the official medical journal of the American Society of Anesthesiologists.

4 Sep 2015

New computational method reveals links between bacterial growth rates and type II diabetes, IBD

It is increasingly clear that the thousands of different bacteria living in our intestinal tract - our microbiome - have a major impact on our health. But the details of the microbiome's effects are still fairly murky.

3 Sep 2015

Regulatory T cells may reduce susceptibility to allergies

Susceptibility to allergies reduced by increased production of regulatory T cells. This is the main finding of a current study being conducted at the Institute of Immunology at MedUni Vienna, headed up by Winfried F. Pickl. The initial results of this study by Alina Neunkirchner, which looks at the root cause of the development of allergies, are being presented at the European Congress of Immunology, which starts in Vienna this Sunday (6 - 9 September 2015, Austria Center Vienna).

3 Sep 2015

Scientists pinpoint neurons responsible for alcohol consumption

Scientists have pinpointed a population of neurons in the brain that influences whether one drink leads to two, which could ultimately lead to a cure for alcoholism and other addictions.

3 Sep 2015

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'.

28 Aug 2015

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife.

28 Aug 2015

High dietary iron intake suppresses hormone that regulates appetite

Here's one more reason to cut down on the amount of red meat you eat. Using an animal model, researchers at Wake Forest Baptist Medical Center have found that dietary iron intake, equivalent to heavy red meat consumption, suppresses leptin, a hormone that regulates appetite.

25 Aug 2015

Researchers identify strategy to prevent adenoviruses from multiplying and causing sickness in humans

Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.

21 Aug 2015

CMU engineers awarded NSF grant to study neural variability in motor learning

When we move, we rarely move in the exact same way twice. The National Science Foundation has awarded Carnegie Mellon University Assistant Professor of Biomedical Engineering Steven Chase and Associate Professor of Electrical and Computer Engineering and Biomedical Engineering Byron Yu, and their long-time collaborator, University of Pittsburgh Associate Professor of Bioengineering Aaron Batista, an $869,000 grant to conduct basic research that will establish how variability in movement is encoded in the brain and how this variability contributes to learning and performance.

13 Aug 2015

Ardelyx reports net income of $9.0 million for second quarter 2015

Ardelyx, Inc., a clinical-stage biopharmaceutical company focused on gastrointestinal and cardio-renal diseases, today announced financial results for the second quarter ended June 30, 2015.

12 Aug 2015

UNC researchers show how a genetic mutation disables molecular switch and causes autism

Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC School of Medicine researchers are the first to show how one of these mutations disables a molecular switch in one of these genes and causes autism.

7 Aug 2015

Molecular packaging enhances cancer drug’s effectiveness at destroying tumors

Researchers have packaged a widely used cancer drug into nanoparticles, more than doubling its effectiveness at destroying tumors.

5 Aug 2015

UBC scientists reveal new weapon to combat malnutrition

UBC scientists have opened the doors to new research into malnutrition by creating an animal model that replicates the imbalance of gut bacteria associated with the difficult-to-treat disease.

5 Aug 2015

New study reports creation of genetic porcine model of cancer

With many types of cancers, early detection offers the best hope for survival. However, research into new early-detection screenings, as well as possible interventional radiology and surgical treatments, has been hindered by the lack of a large animal model that would accurately reflect the types of cancers seen in human cells.

30 Jul 2015

Drug addiction expert uncovers molecular mechanisms that contribute to addiction resistance

Growing up in West Virginia, Jill Turner saw firsthand the kind of havoc that drug addiction can wreak. "I had a lot of friends who had very promising lives and promising careers ahead of them," the assistant professor in the South Carolina College of Pharmacy says, "but they ended up either overdosing or going to jail for drug-related stuff. It's one of the reasons I went into drug addiction research."

22 Jul 2015

New approach holds great promise for developing effective treatments for human mitochondrial diseases

Using existing drugs, such as lithium, to restore basic biological processes in human cells and animal models, researchers may have broken a long-standing logjam in devising effective treatments for human mitochondrial diseases.

21 Jul 2015

Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

US-Australian drug discovery company, Novogen Limited, today announced that it has received notification from the U.S. Food and Drug Administration that its chemotherapy candidate drug, Anisina, has been granted Orphan Drug Designation for neuroblastoma.

16 Jul 2015

Research could lead to new approaches to treating spinal cord and brain injuries

Many an injury will heal, but the damaged spinal cord is notoriously recalcitrant. There's new hope on the horizon, though. A team of researchers led by the University of South Carolina's Jeff Twiss just reported an innate repair mechanism in central nervous system axons that might be harnessed to regenerate nerves after brain or spinal cord injuries.

16 Jul 2015

Gene therapy provides life-long protection to photoreceptor cells in animal model of retinitis pigmentosa

A collaboration between scientists in the UK and the USA has shown that gene therapy can give life-long protection to the light-sensitive photoreceptor cells responsible for colour vision in a mouse model of the most common inherited eye disorder.

15 Jul 2015

Transplanted MSCs slow progression of lupus nephritis by suppressing Tfh cells in SLE animal model

Systemic lupus erythematosus (SLE) is an autoimmune disease that produces autoantibodies and subsequent immune reactions that can lead to a variety of symptoms, including inflammation of the kidneys, or nephritis. When researchers transplanted mesenchymal stem cells (MSCs) derived from human bone marrow into mice modeled with SLE, they found that inflammation was reduced and nephritis "attenuated."

15 Jul 2015

Animal Model News and Research

Repeated exposure to anesthesia early in life causes long-term behavioral changes

New computational method reveals links between bacterial growth rates and type II diabetes, IBD

Regulatory T cells may reduce susceptibility to allergies

Scientists pinpoint neurons responsible for alcohol consumption

Scientists uncover mechanism responsible for development of adrenal gland tumors

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

High dietary iron intake suppresses hormone that regulates appetite

Researchers identify strategy to prevent adenoviruses from multiplying and causing sickness in humans

CMU engineers awarded NSF grant to study neural variability in motor learning

Ardelyx reports net income of $9.0 million for second quarter 2015

UNC researchers show how a genetic mutation disables molecular switch and causes autism

Molecular packaging enhances cancer drug’s effectiveness at destroying tumors

UBC scientists reveal new weapon to combat malnutrition

New study reports creation of genetic porcine model of cancer

Drug addiction expert uncovers molecular mechanisms that contribute to addiction resistance

New approach holds great promise for developing effective treatments for human mitochondrial diseases

Novogen's Anisina granted FDA Orphan Drug Designation for neuroblastoma

Research could lead to new approaches to treating spinal cord and brain injuries

Gene therapy provides life-long protection to photoreceptor cells in animal model of retinitis pigmentosa

Transplanted MSCs slow progression of lupus nephritis by suppressing Tfh cells in SLE animal model

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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