Chromosome 8 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 8, one copy inherited from each parent, form one of the pairs. Chromosome 8 spans about 146 million DNA building blocks (base pairs) and represents between 4.5 percent and 5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 8 likely contains between 700 and 1,100 genes.

Genes on chromosome 8 are among the estimated 20,000 to 25,000 total genes in the human genome.

Six in every ten serious heart defects in foetuses go undetected in ultrasound scans

Over six in every ten serious heart defects in foetuses go undetected in the ultrasound scans given to all pregnant women. According to research at Linköping University in Sweden, one reason why malformations are not found is obesity in the expectant mother.

13 Mar 2014

Study finds gene expression differences in male and female athletes with ACL injuries

Female athletes are two-to-eight times more likely to suffer an anterior cruciate ligament (ACL) injury than males. And while there have been reports about possible anatomic, hormonal and neuromuscular factors that may place females at greater risk for these injuries, little research has looked specifically at the role of genetics.

13 Mar 2014

Researchers discover two new gene regions connected to bipolar disorder

First on top of the world and then in the depths of despair - this is what the extreme mood changes for people with bipolar disorder are like. Under the direction of scientists from Bonn, Mannheim and Basel, an international collaboration of researchers discovered two new gene regions that are connected to the prevalent disease. In addition, they were able to confirm three additional suspect genes.

11 Mar 2014

Takeda works with UCL to drive research into tackling muscle disorders

Japanese pharmaceutical company Takeda will work with University College London (UCL) to drive research into tackling muscle disorders, in particular muscular dystrophy.

10 Mar 2014

Oxford Gene Technology announces acquisition of Cytocell

Oxford Gene Technology, a provider of innovative genetics research solutions, today announced the acquisition of Cambridge-based Cytocell Limited, a leading provider of DNA technology for the detection of gene rearrangements related to inherited genetic disease and cancer.

From Oxford Gene Technology 4 Mar 2014

Biostatistics provides clues to understanding autism: an interview with Dr Knut M. Wittkowski, The Rockefeller University

The incidence of autism spectrum disorders has increased sharply since it was first described 60 years ago. Today, ASD affects more than 1% of all children in the U.S. and about half of them develop a life-long disability.

3 Mar 2014

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi- prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18.

From Illumina, Inc. 27 Feb 2014

Pharmacyclics total revenue for fourth quarter 2013 increases 113% to $123.6 million

Pharmacyclics, Inc. today reported financial results and recent developments for the quarter and year ended December 31, 2013.

20 Feb 2014

Researchers identify gene variants that substantially increase risk for schizophrenia

Schizophrenia has long been known to be highly heritable and is present in approximately 1% of the population. Researchers have been following two paths in their pursuit of identifying schizophrenia risk genes.

20 Feb 2014

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The research appears February 19 as an advanced online publication in the scientific journal Nature.

20 Feb 2014

Deficiency in SNX27 explains learning impairment in Down's syndrome

Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have identified the precise role of the protein, SNX27, in the pathway leading to memory and learning impairment.

20 Feb 2014

Subtle epigenetic change plays important role in correct segregation of chromosomes

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

17 Feb 2014

Researchers find 'missing' genetic risk in cancer

A new study could help to answer an important riddle in our understanding of genetics: why research to look for the genetic causes of common diseases has failed to explain more than a fraction of the heritable risk of developing them.

14 Feb 2014

Understanding genetic changes associated with aggressive prostate cancer

Researchers at the University of East Anglia have made an important advance in understanding genetic changes associated with terminal prostate cancer.

12 Feb 2014

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Natera, a leading innovator in prenatal genetic testing, today announced the initiation of a distribution partnership with ProPath, a wholly physician-owned provider of pathology services to clinicians and medical facilities in the United States, for its Panorama non-invasive prenatal screening test (NIPT).

From Natera 12 Feb 2014

Researchers investigate sex differences in brain structure

Reviewing over 20 years of neuroscience research into sex differences in brain structure, a Cambridge University team has conducted the first meta-analysis of the evidence, published this week in the prestigious journal Neuroscience and Biobehavioral Reviews.

12 Feb 2014

Study findings suggest potential targets for treating HCV

The hepatitis C virus (HCV) has a previously unrecognized tactic to outwit antiviral responses and sustain a long-term infection. It also turns out that some people are genetically equipped with a strong countermeasure to the virus' attempt to weaken the attack on it.

11 Feb 2014

TGen study reveals genetic origins of breast cancer that spreads to brain

The Translational Genomics Research Institute (TGen) has uncovered possible genetic origins of breast cancer that spreads to the brain, according to a first-of-its-kind study published in the scientific journal PLOS ONE.

11 Feb 2014

Two oncogenes work together to sustain population of cells in lung squamous cell carcinoma

Patients with a common form of lung cancer — lung squamous cell carcinoma — have very few treatment options. That situation may soon change.

10 Feb 2014

Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

Researchers from North Carolina State University have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers.

7 Feb 2014

Chromosome 8 News and Research

Six in every ten serious heart defects in foetuses go undetected in ultrasound scans

Study finds gene expression differences in male and female athletes with ACL injuries

Researchers discover two new gene regions connected to bipolar disorder

Takeda works with UCL to drive research into tackling muscle disorders

Oxford Gene Technology announces acquisition of Cytocell

Biostatistics provides clues to understanding autism: an interview with Dr Knut M. Wittkowski, The Rockefeller University

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

Pharmacyclics total revenue for fourth quarter 2013 increases 113% to $123.6 million

Researchers identify gene variants that substantially increase risk for schizophrenia

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

Deficiency in SNX27 explains learning impairment in Down's syndrome

Subtle epigenetic change plays important role in correct segregation of chromosomes

Researchers find 'missing' genetic risk in cancer

Understanding genetic changes associated with aggressive prostate cancer

Natera initiates distribution partnership with ProPath for Panorama non-invasive prenatal screening test

Researchers investigate sex differences in brain structure

Study findings suggest potential targets for treating HCV

TGen study reveals genetic origins of breast cancer that spreads to brain

Two oncogenes work together to sustain population of cells in lung squamous cell carcinoma

Researchers find link between mutations in gene called RAB 24 and inherited neurodegenerative disease

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