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Placental inflammation's role in adult depression and heart disease

An expression signature related to inflammation expressed in Hofbauer cells in the placenta, calculating polygenic risk scores to predict its expression.

14 Nov 2023

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

13 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM.

13 Nov 2023

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

In a comprehensive multi-ancestry GWAS meta-analysis, researchers identified 451 risk variants for prostate cancer, including 187 new variants, demonstrating the utility of such studies across diverse populations. This analysis not only increased understanding of genetic risk factors but also differentiated between aggressive and non-aggressive prostate cancer types, underscoring the potential of genetic risk scoring in guiding screening and early detection strategies.

12 Nov 2023

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

In an Australian study published in EClinicalMedicine, researchers evaluated the impact of a combined genomic screening program for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia in young adults. The program proved to be cost-effective, reducing healthcare costs and averting numerous health events, while emphasizing the need for further optimization and equitable access within public healthcare systems.

12 Nov 2023

New insights into migraine etiology: the role of hepatocyte growth factor

The causal links between pro-inflammatory cytokine expression and migraine.

10 Nov 2023

New research aims to decipher how animals discard half their genes

New research is underway to decipher a fascinating biological puzzle - how some animals can naturally discard more than half of their genetic information during embryonic development.

9 Nov 2023

Researchers reveal mechanism by which MAF protein increases metastasis risk in breast cancer patients

Breast cancer is the most common form of cancer among women, with more than 2 million new cases diagnosed each year. In cases where the tumour remains localised in the breast, survival rates are remarkably high, at around 90%.

9 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

MD Anderson Cancer launches Institute for Data Science in to transform cancer care and research

The University of Texas MD Anderson Cancer Center today announced the launch of its Institute for Data Science in Oncology (IDSO), which integrates the most advanced computational and data science approaches with the institution's extensive scientific and clinical expertise to significantly improve patient's lives by transforming cancer care and research.

9 Nov 2023

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk - 451 in all - through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

9 Nov 2023

Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups.

8 Nov 2023

New antifungal molecule shows promise in combatting fungal infections without toxicity

A new antifungal molecule, devised by tweaking the structure of prominent antifungal drug Amphotericin B, has the potential to harness the drug's power against fungal infections while doing away with its toxicity, researchers at the University of Illinois Urbana-Champaign and collaborators at the University of Wisconsin-Madison report in the journal Nature.

8 Nov 2023

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.

8 Nov 2023

Study validates first-in-class AI-driven digital pathology colorectal cancer diagnostic tool

In a peer-reviewed study published today in Nature Communications, a team of scientists from French-American techbio Owkin and pathology labs in France present a blind validation of MSIntuit CRC, a first-in-class AI-driven digital pathology diagnostic developed by Owkin, as a pre-screening tool aimed at optimizing the precision of diagnosis and treatment of colorectal cancer.

7 Nov 2023

Study links gut bacteria single-nucleotide polymorphisms to BMI

Researchers investigated the potential implications of single-nucleotide variations in gut-residing bacterial species (microbiome) on human health.

7 Nov 2023

Researchers announce a new genetic classification system for gastric cancer

Professor Sang Cheul Oh of the Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Professor Sang‑Hee Kang of the Department of Surgery, Korea University's Guro Hospital, and Professor Sun Young Yim of the Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine announced a new genetic classification system for gastric cancer by a multicenter study with the University of Texas MD Anderson Cancer Center.

6 Nov 2023

AI tools may be effective at detecting heart valvular disease and predicting cardiovascular risk

Advances in artificial intelligence have enabled the development and application of AI tools that may be effective at detecting heart valvular disease and predicting the risk of cardiovascular disease events, according to preliminary research in two studies to be presented at the American Heart Association's Scientific Sessions 2023.

6 Nov 2023

Genomic News and Research

Placental inflammation's role in adult depression and heart disease

New study identifies 4,749 key gene clusters that influence progression of 32 cancer types

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Crown Bioscience launches large-scale organoid panel screening platform for accelerated preclinical oncology drug discovery

Multi-ancestry study reveals 187 new genetic risk factors for prostate cancer

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

New insights into migraine etiology: the role of hepatocyte growth factor

New research aims to decipher how animals discard half their genes

Researchers reveal mechanism by which MAF protein increases metastasis risk in breast cancer patients

Preclinical discovery could point the way toward better treatments for type 2 diabetes

Tumor-immune interactions predict treatment responses in multiple myeloma

MD Anderson Cancer launches Institute for Data Science in to transform cancer care and research

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

Genetic melting pot: Study unveils complex admixture in European ancestry populations

New antifungal molecule shows promise in combatting fungal infections without toxicity

Simultaneous inhibition of two proteins may be a new strategy for tackling triple-negative breast cancer

Study validates first-in-class AI-driven digital pathology colorectal cancer diagnostic tool

Study links gut bacteria single-nucleotide polymorphisms to BMI

Researchers announce a new genetic classification system for gastric cancer

AI tools may be effective at detecting heart valvular disease and predicting cardiovascular risk

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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